Liquid secretion properties of airway submucosal glands

Journal of Physiology

Volumn 556, Issue 1, 2004, Pages 1-10

  Ballard, Stephen T ^a   Inglis, Sarah K ^b  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CALCIUM ION; CHLORIDE CHANNEL; CHLORIDE ION; POTASSIUM CHANNEL; POTASSIUM ION; TRANSMEMBRANE CONDUCTANCE REGULATOR; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ION; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

BRONCHUS MUCUS; CALCIUM CELL LEVEL; CELL MEMBRANE PERMEABILITY; CELL SECRETION; CYSTIC FIBROSIS; FLUID TRANSPORT; HUMAN; LUNG DISEASE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; REGULATORY MECHANISM; RESPIRATORY TRACT MUCOSA; REVIEW; SUBMUCOSA; TRACHEA MUCUS; ARTICLE; AUTOCRINE EFFECT; BRONCHUS SECRETION; EXOCRINE GLAND; ION TRANSPORT; LIQUID SECRETION; MORPHOMETRICS; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SECRETION (PROCESS); SUBMUCOSAL GLAND;

ANIMALS; BRONCHI; CYSTIC FIBROSIS; HUMANS; LIPIDS; RESPIRATORY MUCOSA; TRACHEA;

EID: 1942421832     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.052779     Document Type: Review

References (89)

1. Anderson MP, Gregory RJ, Thompson S, Sousa DW, Paul S, Mulligan RC, Smith AE & Welsh MJ (1991). Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 253, 202-205.
2. Ballard ST, Fountain JD, Inglis SK, Corboz MR & Taylor AE (1995). Chloride secretion across distal airway epithelium: relationship to submucosal gland distribution. Am J Physiol 268, L526-L531.
3. Ballard ST, Trout L, Bebök Z, Sorscher EJ & Crews A (1999). CFTR involvement in chloride, bicarbonate and liquid secretion by airway submucosal glands. Am J Physiol 277, L694-L699.
4. Ballard ST, Trout L, Mehta A & Inglis SK (2002). Liquid secretion inhibitors reduce mucociliary transport in glandular airways. Am J Physiol 283, L329-L335.
5. Basbaum CB, Jany B & Finkbeiner WE (1990). The serous cell. Annu Rev Physiol 52, 97-113.
6. Becq F, Merten MD, Voelckel MA, Gola M & Figarella C (1993). Characterization of cAMP dependent CFTR-chloride channels in human tracheal gland cells. FEBS Lett 321, 73-78.
7. Bloom W & Fawcett DW (1975). A Textbook of Histology, 10th edn. W.B. Saunders, Philadelphia.
8. Borson DB, Chin RA, Davis B & Nadel JA (1980). Adrenergic and cholinergic nerves mediate fluid secretion from tracheal glands of ferrets. J Appl Physiol 49, 1027-1031.
9. Borthwick DW, West JD, Keighren MA, Flockhart JH, Innes BA & Dorin JR (1999). Murine submucosal glands are clonally derived and show a cystic fibrosis gene-dependent distribution pattern. Am J Respir Cell Mol Biol 20, 1181-1189.
10. Boucher RC & Gatzy JT (1982). Regional effects of autonomic agents in ion transport across excised canine airways. J Appl Physiol 52, 893-901.
11. + channel subunits in normal and cystic fibrosis airways. Am J Physiol 269, C511-C518.
12. Choi HK, Finkbeiner WE & Widdicombe JH (2000). A comparative study of mammalian tracheal mucous glands. J Anat 197, 361-372.
13. Cobb BR, Ruiz F, King CM, Fortenberry J, Greer H, Kovacs T, Sorscher EJ & Clancy JP (2002). A2 adenosine receptors regulate CFTR through PKA and PLA2. Am J Physiol 282, L12-L25.
14. + channels underlying anion secretion in the human airway cell line Calu-3. J Physiol 538, 747-757.
15. Cuthbert AW, Supuran CT & MacVinish LJ (2003). Bicarbonate-dependent chloride secretion in Calu-3 epithelia in response to 7,8-benzoquinoline. J Physiol 551, 79-92.
16. Davis B, Roberts AM, Coleridge HM & Coleridge JCG (1982). Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs. J Appl Physiol 53, 985-991.
17. Devor DC, Singh AK, Lambert LC, DeLuca A, Frizzell RA & Bridges RJ (1999). Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells. J General Physiol 133, 743-760.
18. Engelhardt JF, Yankaskas JR, Ernst ST, Yang Y, Marino CR, Boucher RC, Cohn JA & Wilson JM (1992). Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat Genet 2, 240-248.
19. Fischer A, Canning BJ & Kummer W (1996). Correlation of vasoactive intestinal peptide and nitric oxide synthase with choline acetyltransferase in the airway innervation. Ann N Y Acad Sci 805, 717-722.
20. Goco RV, Kress MB & Brantigan OC (1963). Comparison of mucus glands in the tracheobronchial tree of man and animals. Ann NY Acad Sci 106, 555-571.
21. Groneberg DA, Hartmann P, Dihn QT & Fischer A (2001). Expression and distribution of vasoactive intestinal polypeptide receptor VPAC2 mRNA in human airways. Laboratory Invest 81, 749-755.
22. Guyot A & Hanrahan JW (2002). ATP release from human airway epithelial cells studied using a capillary culture system. J Physiol 545, 199-206.
23. - conductance. Am J Physiol 266, L502-L512.
24. Haxhiu MA, Haxhiu-Poskurica B, Moracic V, Carlo WA & Martin RJ (1990). Reflex and chemical responses of trachea; submucosal glands in piglets. Respir Physiol 82, 267-278.
25. Hejal R, Strohl KP, Erokwu B, Cherniack NS & Haxhiu MA (1995). Effect of hypoxia on reflex responses of tracheal submucosal glands. J Appl Physiol 78, 1651-1656.
26. Huang P, Lazarowski ER, Tarran R, Milgram SL, Boucher RC & Stutts MJ (2001). Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells. Proc Natl Acad Sci U S A 98, 14120-14125.
27. Hug MJ & Bridges RJ (2001). pH regulation and bicarbonate transport of isolated porcine submucosal glands. J Pancreas (Online) 2, 274-279.
28. Inglis SK, Corboz MR, Taylor AE & Ballard ST (1997a). In situ visualization of bronchial submucosal glands and their secretory response to acetylcholine. Am J Physiol 272, L203-L210.
29. Inglis SK, Corboz MR, Taylor AE & Ballard ST (1997b). Effect of anion transport inhibition on mucus secretion by airway submucosal glands. Am J Physiol 272, L372-L377.
30. Inglis SK, Finlay L, Ramminger SJ, Richard K, Ward MR, Wilson SM & Olver RE (2002). Regulation of intracellular pH in Calu-3 human airway cells. J Physiol 538, 527-539.
31. Inglis SK, Wilson SM & Olver RE (2003). Secretion of acid and base equivalents by intact distal airways. Am J Physiol 284, L855-L862.
32. Ishihara H, Shimura S, Satoh M, Masuda T, Nonaka H, Kase H, Sasaki T, Takishima T & Tamura K (1992). Muscarinic receptor subtypes in feline tracheal submucosal gland secretion. Am J Physiol 262, L223-L228.
33. Jacquot JE, Puchelle E, Hinnrasky J, Fuchey C, Bettinger C, Spilmont C, Bonnet N, Dieterle A, Dreyer D, Pavirani A & Dalemans W (1993). Localization of the cystic fibrosis transmembrane conductance regulator in airway secretory glands. Eur Respir J 6, 169-176.
34. +] and pH but elevated viscosity. Proc Natl Acad Sci U S A 98, 8119-8123.
35. Joo NS, Irokawa T, Wu JV, Robbins RC, Whyte RI & Wine JJ (2002a). Absent secretion to vasoactive intestinal peptide in cystic fibrosis airway glands. J Biol Chem 277, 50710-50715.
36. Joo NS, Saenz Y, Krouse ME & Wine JJ (2002b). Mucus secretion from single submucosal glands of pig. J Biol Chem 277, 28167-28175.
37. Joo NS, Wu JV, Krouse ME, Saenz Y & Wine WW (2001). Optical method for quantifying rates of mucus secretion from single submucosal glands. Am J Physiol 281, L458-L468.
38. Khawaja AM, Liu Y-C & Rogers DF (1999). Effect of non-peptide tachykinin NK1 receptor antagonists on non-adrenergic, non-cholinergic neurogenic mucus secretion in ferret trachea. Eur J Pharmacol 384, 173-181.
39. Kreda SM, Gynn MC, Fenstermacher DA, Boucher RC & Gabriel SE (2001). Expression and localization of epithelial aquaporins in the adult human lung. Am J Respir Cell Mol Biol 24, 224-234.
40. Loffing J, Moyer BD, Reynolds D, Shmukler BE, Alper SL & Stanton BA (2000). Functional and molecular characterization of an anion exchanger in airway serous epithelial cells. Am J Physiol 279, C1016-C1023.
41. Meyrick B, Sturgess JM & Reid L (1969). A reconstruction of the duct system and secretory tubules of the human bronchial submucosal gland. Thorax 24, 729-736.
42. - secretion in Calu-3 human airway cells requires CFTR. Am J Physiol 273, L1208-L1219.
43. - transport and mucous gland secretion in airway epithelium. Ciba Foundation Symp 54, 133-147.
44. i rise in the acinar cells of feline tracheal submucosal gland. Respir Physiol 98, 111-120.
45. Oppenheimer EH & Esterly JR (1975). Pathology of cystic fibrosis: review of the literature and comparison with 146 autopsied cases. In Perspectives in Pediatric Pathology, vol. 2, ed. Dosenberg HS & Bolarde RP, pp. 421-278. Yearbook Medical Publications, Chicago.
46. Ornoy A, Arnon J, Katznelson D, Granat M, Caspi B & Chemke J (1987). Pathological confirmation of cystic fibrosis in the fetus following prenatal diagnosis. Am J Med General 28, 935-947.
47. Phillips JE, Hey JA & Corboz MR (2002a). Computer assisted measurement of airway gland secretions by the hillocks technique. Comp Meth Prog Biomed 68, 215-222.
48. Phillips JE, Hey JA & Corboz MR (2002b). Effects of ion transport inhibitors on MCh-mediated secretion from porcine airway submucosal glands. J Appl Physiol 93, 873-881.
49. Phillips JE, Hey JA & Corboz MR (2003). Tachykinin NK3 and NK1 receptor activation elicits secretion from porcine airway submucosal glands. Br J Pharmacol 138, 254-260.
50. Poulsen JH, Fischer H, Illek B & Machen TE (1994). Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A 91, 5340-5344.
51. Quinton PM (1979). Composition and control of secretions from tracheal bronchial submucosal glands. Nature 279, 551-552.
52. Quinton PM (1981). Possible mechanisms of stimulus-induced vacuolation in serous cells of tracheal secretory glands. Am J Physiol 241, C25-C32.
53. Quinton PM (1983). Chloride impermeability in cystic fibrosis. Nature 301, 421-422.
54. Quinton PM (1999). Physiological basis of cystic fibrosis: A historical perspective. Physiol Rev 79, S3-S22.
55. Revel JP & Karnovsky MJ (1967). Hexagonal array of subunits in intercellular junctions of the mouse heart and liver. J Cell Biol 33, C7-C12.
56. Riordan JR, Rommens JM, Kerem B-S, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou J-L, Drumm ML, Iannuzzi MC, Collins FS & Tsui L-C (1989). Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245, 1066-1073.
57. Rogers DF (1993). Airway submucosal gland and goblet cell secretion. In Pharmacology of the Respiratory Tract. Experimental and Clinical Research, ed. Chung KF & Barnes PJ, pp. 583-620. Marcel Dekker, New York.
58. Rogers DF (2000). Motor control of airway goblet cells and glands. Respir Physiol 125, 129-144.
59. Sasaki T, Shimura S, Ikeda K, Sasaki H & Takishima T (1990). Sodium efflux from isolated submucosal gland in feline trachea. Am J Physiol 258, L112-L117.
60. Sasaki T, Shimura S, Wakui M, Ohkawara Y, Takishima T & Mikoshiba K (1994). Apically localized IP3 receptors control chloride current in airway gland acinar cells. Am J Physiol 267, L152-L158.
61. Schneeberger EE & McCormack JM (1984). Intracellular junctions in upper airway submucosal glands of the rat: a tracer and freeze fracture study. Anat Rec 210, 421-433.
62. Schuster A, Ueki I & Nadel JA (1992). Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200,355. Am J Physiol 262, L86-L91.
63. - secretion. Am J Physiol 266, L493-L501.
64. Shimura S, Ishihara H, Nagaki M, Sasaki H & Takishima T (1993). A stimulatory role of protein kinase C in feline tracheal submucosal gland secretion. Respir Physiol 93, 239-247.
65. Shimura S, Sasaki T, Okayama H, Sasaki H & Takishima T (1987). Neural control of contraction in isolated submucosal gland from feline trachea. J Appl Physiol 62, 2404-2409.
66. Shimura S, Sasaki T, Sasaki H & Takishima T (1986). Contractility of isolated single submucosal gland from trachea. J Appl Physiol 60, 1237-1247.
67. Shimura S & Takishima T (1994). Airway submucosal gland secretion. In Airway Secretion: Physiological Bases for the Control of Mucous Hypersecretion, ed. Takishima T & Shimura S, pp. 325-398. Marcel Dekker, New York.
68. Smith PL & Frizzell RA (1984). Chloride secretion by canine tracheal epithelium: IV. Basolateral membrane K permeability parallels secretion rate. J Membr Biol 77, 187-199.
69. Sommerhoff CP & Finkbeiner WE (1990). Human tracheobronchial submucosal gland cells in culture. Am J Respir Cell Mol Biol 2, 41-50.
70. Song Y & Verkman AS (2001). Aquaporin-5 dependent fluid secretion in airway submucosal glands. J Biol Chem 276, 41288-41292.
71. Sorkin SP (1965). On the cytology and cytochemistry of the opossum bronchial glands. Am J Anat 117, 311-338.
72. Spicer SS, Sens MA & Tashian RE (1982). Immunocytochemical demonstration of carbonic anhydrase in human epithelial cells. J Histochem Cytochem 30, 864-873.
73. Steiger J, Bray MA & Subramanian N (1987). Platelet-activating factor (PAF) is a potent stimulator of porcine tracheal fluid secretion in vitro. Eur J Pharmacol 142, 367-372.
74. - channel in CHO cells stably expressing the cystic fibrosis gene. Nature 352, 628-631.
75. Takizawa T & Thurlbeck WM (1971). A comparative study of four methods of assessing the morphologic changes in chronic bronchitis. Am Rev Respir Dis 103, 774-783.
76. Tos M (1966). Development of the tracheal glands in man. Acta Pathol Microbiol Scand supplement 185, 1-130.
77. Tos M (1976). Mucous elements in the airways. Acta Otolaryngol 82, 249-251.
78. Trout L, Corboz MR & Ballard ST (2001). Mechanism of substance P-induced liquid secretion across porcine bronchial epithelium. Am J Physiol 281, L639-L645.
79. - transport. Am J Physiol 275, L1095-L1099.
80. Trout L, King M, Feng W, Inglis SK & Ballard ST (1998b). Inhibition of airway liquid secretion and its effects on the physical properties of airway mucus. Am J Physiol 274, L258-L263.
81. Trout L, Townsley MI, Bowden A & Ballard ST (2003). Disruptive effects of anion secretion inhibitors on airway mucus morphology in isolated perfused pig lungs. J Physiol 549, 845-853.
82. Ueki I, German VF & Nadel JA (1980). Micropipette measurement of airway submucosal gland secretion. Autonomic effects. Am Rev Respir Dis 121, 351-357.
83. Webber SE (1989). Receptors mediating the effects of substance P and neurokinin A on mucus secretion and smooth muscle tone of the ferret trachea: potentiation by an enkephalinase inhibitor. Br J Pharmacol 98, 1197-1206.
84. Webber SE, Lim JCS & Widdicombe JG (1991). The effects of calcitonin gene-related peptide on submucosal gland secretion and epithelial albumin transport in the ferret trachea in vitro. Br J Pharmacol 102, 79-84.
85. Widdicombe JH, Chen LL, Sporer H, Choi HK, Pecson IS & Bastacky SJ (2001). Distribution of tracheal and laryngeal mucous glands in some rodents and the rabbit. J Anat 198, 207-221.
86. Yamaya M, Ourui T, Finkbeiner WE & Widdicombe JH (1993). Calcium-dependent chloride secretion across cultures of human tracheal surface epithelium and glands. Am J Physiol 265, L170-L177.
87. Yamaya M, Sekizawa K, Kakuta Y, Ohrui T, Sawai T & Sasaki H (1996). P2U-purinoceptor regulation of chloride secretion in cultured human tracheal submucosal glands. Am J Physiol 270, L979-L984.
88. Yang CM, Farley JM & Dwyer TM (1988). Acetylcholine-stimulated chloride flux in tracheal submucosal gland cells. J Appl Physiol 65, 1891-1894.
89. Zuelzer WW & Newton WA (1949). The pathogenesis of fibrocystic disease of the pancreas. Pediatrics 4, 53-69.