Acetylcholine-induced liquid secretion by bronchial epithelium: Role of Cl- and HCO3/- transport

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 275, Issue 6 19-6, 1998, Pages

  Trout, Laura ^a   Gatzy, John T ^b   Ballard, Stephen T ^a,c  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Bicarbonate; Bronchi; Bumetanide; Chloride; Cystic fibrosis; Dimethylamiloride; Submucosal glands

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; ACETYLCHOLINE; BICARBONATE; BUMETANIDE; CHLORIDE;

ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; BRONCHUS MUCOSA; BRONCHUS SECRETION; CHLORIDE TRANSPORT; CONTROLLED STUDY; LIQUID; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0032447139     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1998.275.6.l1095     Document Type: Article

References (22)

1. Anderson, M. P., R. J. Gregory, S. Thompson, D. W. Sousa, S. Paul, R. C. Mulligan, A. E. Smith, and M. J. Welsh. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 253: 202-205, 1991.
2. Bittner, O., and S. G. Hall. The titration of bicarbonate in plasma - critical factors. Am. J. Clin. Pathol. 42: 522, 1964.
3. Borson, D. B., R. A. Chin, B. Davis, and J. A. Nadel. Adrenergic and cholinergic nerves mediate fluid secretion from tracheal glands of ferrets. J. Appl. Physiol. 49: 1027-1031, 1980.
4. Boucher, R. C. Human airway ion transport, part one. Am. J. Respir. Crit. Care Med. 150: 271-281, 1994.
5. Boucher, R. C. Human airway ion transport, part two. Am. J. Respir. Crit. Care Med. 150: 581-593, 1994.
6. Boucher, R. C., and J. T. Gatzy. Regional effects of autonomic agents on ion transport across excised canine airways. J. Appl. Physiol. 52: 893-901, 1982.
7. Case, R. M., M. Hunter, I. Novak, and J. A. Young. The anionic basis of fluid secretion by the rabbit mandibular salivary gland. J. Physiol. (Lond.) 349: 619-630, 1984.
8. Engelhardt, J. F., J. R. Yankaskas, S. T. Ernst, Y. Yang, C. R. Marino, R. C. Boucher, J. A. Cohn, and J. M. Wilson. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat. Genet. 2: 240-248, 1992.
9. Inglis, S. T., M. R. Corboz, and S. T. Ballard. Effect of anion secretion inhibitors on mucin content of airway submucosal gland ducts. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L762-L766, 1998.
10. Inglis, S. K., M. R. Corboz, A. E. Taylor, and S. T. Ballard. Regulation of ion transport across porcine distal bronchi. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L289-L297, 1996.
11. Inglis, S. K., M. R. Corboz, A. E. Taylor, and S. T. Ballard. Effect of anion transport inhibition on mucus secretion by airway submucosal glands. Am. J. Physiol. 272 (Lung Cell. Mol. Physiol. 16): L372-L377, 1997.
12. Jarnigan, F., J. D. Davis, P. A. Bromberg, J. T. Gatzy, and R. C. Boucher. Bioelectric properties and ion transport of excised rabbit trachea. J. Appl. Physiol. 55: 1884-1892, 1983.
13. Jiang, C., W. E. Finkbeiner, J. H. Widdicombe, and S. S. Miller. Fluid transport across cultures of human tracheal glands is altered in cystic fibrosis. J. Physiol. (Lond.) 501: 637-647, 1997.
14. - secretion in Calu-3 human airway cells requires CFTR. Am. J. Physiol. 273 (Lung Cell. Mol. Physiol. 17): L1208-L1219, 1997.
15. Poulsen, J. H., H. Fischer, B. Illek, and T. E. Machen. Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc. Natl. Acad. Sci. USA 91: 5340-5344, 1994.
16. Quinton, P. M. Composition and control of secretions from tracheal bronchial submucosal glands. Nature 279: 551-552, 1979.
17. Quinton, P. M. Cystic fibrosis: a disease in electrolyte transport. FASEB J. 4: 2709-2717, 1990.
18. Silva, P., J. Stoff, M. Field, L. Fine, J. N. Forrest, and F. H. Epstein. Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport. Am. J. Physiol. 233 (Renal Fluid Electrolyte Physiol. 2): F298-F306, 1977.
19. Smith, J. J., and M. J. Welsh. cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia. J. Clin. Invest. 89: 1148-1153, 1992.
20. Tabcharan, J. A., T. J. Jensen, J. R. Riordan, and J. W. Hanrahan. Bicarbonate permeability of the outwardly rectifying anion channel. J. Membr. Biol. 112: 109-122, 1989.
21. Trout, L., M. King, W. Feng, S. K. Inglis, and S. T. Ballard. Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L258-L263, 1998.
22. Ueki, I., V. F. German, and J. A. Nadel. Micropipette measurement of airway submucosal gland secretion. Am. Rev. Respir. Dis. 121: 351-357, 1980.