Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 6 57-6, 2005, Pages

  Andrási, Terézia B ^a,b   Blázovics, Anna ^c   Szabó, Gábor ^a   Vahl, Christian F ^a   Hagl, Siegfried ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Endothelial function; Hemodynamics; Neutrophil adhesion; Nitric oxide

Indexed keywords

MYELOPEROXIDASE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CARDIOPULMONARY BYPASS; CELL ADHESION; CONTROLLED STUDY; DRUG INHIBITION; HEART ARREST; HEART OUTPUT; HEMODYNAMICS; HYPOTHERMIA; MESENTERIC BLOOD VESSEL OCCLUSION; MESENTERY BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; REPERFUSION; SUPERIOR MESENTERIC ARTERY; VASODILATATION;

ANIMALS; CARDIOPULMONARY BYPASS; DISEASE MODELS, ANIMAL; DOGS; ENZYME INHIBITORS; HEART ARREST; HEMODYNAMIC PROCESSES; MYOCARDIAL REPERFUSION; PEROXIDASE; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASES; SPLANCHNIC CIRCULATION;

EID: 19344363861     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01039.2004     Document Type: Article

References (35)

1. Andrási TB, Buhmann V, Soós P, Juhász-Nagy A, and Szabó G. Mesenteric complications after hypothermic cardiopulmonary bypass with cardiac arrest: underlying mechanisms. Artif Organs 26: 943-946, 2002.
2. Andrási TB, Soós P, Bakos G, Stumpf N, Blázovics A, Hagl S, and Szabó G. L-Arginine protects the mesenteric vascular circulation against cardiopulmonary bypass-induced vascular dysfunction. Surgery 134: 72-79, 2003.
3. Binion DG, Fu S, Ramanujam KS, Chai YC, Dweik RA, Drazba JA, Wade JG, Ziats NP, Erzurum SC, and Wilson KT. iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Am J Physiol Gastrointest Liver Physiol 275: G592-G603, 1998.
4. Cuzzocrea S, Chatterjee PK, Mazzon E, Dugo L, De Sarro A, Van de Loo FA, Caputi AP, and Thiemermann C. Role of induced nitric oxide in the initiation of the inflammatory response after postischemic injury. Shock 18: 169-176, 2002.
5. Cuzzocrea S, Ianaro A, Wayman NS, Mazzon E, Pisano B, Dugo L, Serraino I, Di Paola R, Chatterjee PK, Di Rosa M, Caputi AP, and Thiemermann C. The cyclopentenone prostaglandin 15-deoxy-delta (12,14)-PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. Br J Pharmacol 138: 678-688, 2003.
6. Cuzzocrea S, McDonald MC, Mazzon E, Dugo L, Serraino I, Threadgill M, Caputi AP, and Thiemermann C. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem Pharmacol 63: 293-304, 2002.
7. Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL, Caputi AP, and Szabo C. Role of peroxynitrite and activation of poly (ADP-ribose) synthase in the vascular failure induced by zymosan-activated plasma. Br J Pharmacol 122: 493-503, 1997.
8. D'Ancona G, Baillot R, Poirier B, Dagenais F, de Ibarra JI, Bauset R, Mathieu P, and Doyle D. Determinants of gastrointestinal complications in cardiac surgery. Tex Heart Inst J 30: 280-285, 2003.
9. Davies SW, Underwood SM, Wickens DG, Feneck RO, Dormandy TL, and Walesby RK. Systemic pattern of free radical generation during coronary bypass surgery. Br Heart J 64: 236-240, 1999.
10. De Murcia G and Shall S (Editors). From DNA Damage and Stress Signaling to Cell Death. Poly-ADP-Ribosylation Reactions. Oxford, UK: Oxford University Press, 2000.
11. Hayashi Y, Sawa Y, Fukuyama N, Nakazawa H, and Matsuda H. Inducible nitric oxide production is an adaptation to cardiopulmonary bypass-induced inflammatory response. Ann Thorac Surg 72: 149-155, 2001.
12. Hayashi Y, Sawa Y, Fukuyama N, Nakazawa H, and Matsuda H. Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nitric oxide synthase activity. Circulation 106: 2601-2607, 2002.
13. Kelm M. Nitric oxide metabolism and breakdown. Biochim Biophys Acta 1411: 273-289, 1999.
14. Khandoga A, Enders G, Biberthaler P, and Krombach F. Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury. Am J Phisiol Gastrointest Liver Physiol 283: G553-G560, 2002.
15. Kurose I, Wolf R, Grisham MB, Aw TY, Specian RD, and Granger DN. Microvascular responses to inhibition of nitric oxide production. Role of active oxidants. Circ Res 76: 30-39, 1995.
16. Liaudet L, Soriano FG, Szabo E, Virag L, Mabley JG, Salzman AL, and Szabo C. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase. Proc Natl Acad Sci USA 97: 10203-10208, 2000.
17. Liaudet L, Szabó A, Soriano FG, Zingarelli B, Szabó C, and Salzman AL. Poly (ADP-ribose) synthetase mediates intestinal mucosal barrier dysfunction after mesenteric ischemia. Shock 14: 134-141, 2000.
18. Martin DR, Lewington AJ, Hammerman MR, and Padanilam BJ. Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats. Am J Physiol Regul Integr Comp Physiol 279: R1834-R1840, 2000.
19. Mazzon E, Dugo L, De SA, Li JH, Caputi AP, Zhang J, and Cuzzocrea S. Beneficial effects of GPI 6150, an inhibitor of poly(ADP-ribose) polymerase in a rat model of splanchnic artery occlusion and reperfusion. Shock 17: 222-227, 2002.
20. Pesonen EJ, Korpela R, Peltola K, Leijala M, Sairanen H, Raivio KO, Venge P, and Andersson S. Regional generation of free oxygen radicals during cardiopulmonary bypass in children. J Thorac Cardiovasc Surg 110: 768-773, 1995.
21. Sellke FW, Shafique T, Ely DL, and Weintraub RM. Coronary endothelial injury after cardiopulmonary bypass and ischemic cardioplegia is mediated by oxygen-derived free radicals. Circulation 88: II395-II400, 1993.
22. Soriano FG, Pacher P, Mabley J, Liaudet L, and Szabó C. Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 89: 684-691, 2001.
23. Soriano GF, Virag L, Jagtap P, Szabó E, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KG, Salzman AL, Southan GJ, and Szabó C. Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med 7: 108-113: 2001.
24. Szabó C and Billiar TR. Novel roles of nitric oxide in hemorrhagic shock. Shock 12: 1-9, 1999.
25. Szabó C, Cuzzocrea S, Zingarelli B, O'Connor M, and Salzman AL. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J Clin Invest 100: 723-735, 1997.
26. Szabó C, Zanchi A, Komjáti K, Pacher P, Krolewski AS, Quist WC, LoGerfo FW, Horton ES, and Veves A. Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation 106: 2680-2686, 2002.
27. Szabó C, Zingarelli B, and Salzman AL. Role of poly-ADP ribosyl-transferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res 78: 1051-1063, 1996.
28. Szabó G, Bährle S, Stumpf N, Sonnenberg K, Szabó EE, Pacher P, Csont T, Schulz R, Dengler TJ, Liaudet L, Jagtap PG, Southan GJ, Vahl CF, Hagl S, and Szabó C. Poly(ADP-ribose) polymerase inhibition reduces reperfusion injury after heart transplantation. Circ Res 90: 100-106, 2002.
29. Szabó G, Buhmann V, Andrási T, Stumpf N, Bährle S, Kekesi V, Hagl S, Szabó C, and Juhasz-Nagy A. Poly-ADP-ribose polymerase inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest. J Thorac Cardiovasc Surg 126: 651-658, 2003.
30. Takahashi K, Pieper AA, Croul SE, Zhang J, Snyder SH, and Greenberg JH. Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. Brain Res 829: 46-54, 1999.
31. Tofukuji M, Stahl GL, Metais C, Tomita M, Agah A, Bianchi C, Fink MP, and Sellke FW. Mesenteric dysfunction after cardiopulmonary bypass: role of complement C5a. Ann Thorac Surg 69: 799-807, 2000.
32. Wan S, LeClerc JL, and Vincent JL. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest 112: 676-692, 1997.
33. Zacharias A, Schwann TA, Parenteau GL, Riordan CJ, Durham SJ, Engoren M, Fenn-Buderer N, and Habib RH. Predictors of gastrointestinal complications in cardiac surgery. Tex Heart Inst J 27: 93-99, 2000.
34. Zingarelli B, Salzman AL, and Szabó C. Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res 83: 85-94, 1998.
35. Zingarelli B, Szabó C, and Salzman AL. Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis. Gastroenterology 116: 335-345, 1999.