Do the diminishing efficacy and increasing toxicity of sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar, India, justify its continued use as a first-line drug? An observational study of 80 cases

Annals of Tropical Medicine and Parasitology

Volumn 92, Issue 5, 1998, Pages 561-569

  Thakur, C P ^a,c   Sinha, G P ^b   Pandey, A K ^b   Kumar, N ^a   Kumar, P ^a   Hassan, S M ^a   Narain, S ^a   Roy, R K ^a  

^a Kala azar Research Centre   (India)

^b PATNA MEDICAL COLLEGE AND HOSPITAL   (India)

^c NONE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIPROTOZOAL AGENT; STIBOGLUCONATE SODIUM;

ADOLESCENT; ADULT; ANOREXIA; ARTHRALGIA; ARTICLE; CARDIOTOXICITY; CHILD; CLINICAL TRIAL; DRUG EFFICACY; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; INDIA; INJECTION PAIN; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; QT INTERVAL; RELAPSE; ST SEGMENT; SUPRAVENTRICULAR TACHYCARDIA; T WAVE; TASTE DISORDER; TORSADE DES POINTES; VISCERAL LEISHMANIASIS;

NASO HEXACANTHUS; PROTOZOA;

EID: 0031881116     PISSN: 00034983     EISSN: None     Source Type: Journal    
DOI: 10.1080/00034983.1998.11813313     Document Type: Article

References (27)

1. BADARO, R., FALCOFF, E., BADARO, F. S., CARVALHO, E. M., PEDRAL-SAMPAIO, D., BARRAL, A., CARVALHO, J. S., BARRAL-NETTO, M., BRANDLEY, M., SILVA, L., BINA, J. C., TEIXEIRA, R., FALCOFF, R., ROCHA, H., HO, J. L. & JOHNSON JR, W. D. (1990). Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. New England Journal of Medicine, 322, 16-21.
2. CHULAV, J. D., SPENCER, H. C. & MUGAMBI, M. (1985). Electrocardiografic changes during treatment of leishmaniasis with pentavalent antimony (sodium stibogluconate). American Journal of Tropical Medicine and Hygiene, 34, 702-709.
3. GROGLE, M., ODOULA, A. M., CORDERO, L. D. & KYLE, D. E. (1989). Leishmania spp: development of pentostam-resistant clones in vitro by discontinuous drug exposure. Experimental Parasitology, 69, 78-90.
4. GUPTA, P. C. S. (1953). Chemotherapy of leishmanial diseases: a résumé of recent researches. Indian Medical Gazette, 88, 20-35.
5. GUPTA, P. C. S. (1960). Leishmaniasis. In A Handbook of Tropical Diseases, eds Banerjee, J. C. & Bhattacharya, P. B. pp. 103-140. Calcutta: Academic.
6. HERWALDT, B. L. & BERMAN, J. D. (1992). Recommendations for treating leishmaniasis with sodium stibogluconate (pentostam) and review of pertinent clinical studies. American Journal of Tropical Medicine and Hygiene, 46, 296-306.
7. JHA, T. K., SINGH, N. K. P. & JHA, S. (1992). Therapeutic use of sodium stibogluconate in kala-azar from some hyperendemic districts of some hyperendemic districts of north Bihar (India). Journal of the Association of Physicians of India, 42, 868.
8. MANSON-BAHR, P. E. C. (1959). East African kala-azar with special references to the pathology, prophylaxis and treatment. Transactions of Royal Society of Tropical Medicine and Hygiene, 53, 123-137.
9. MANSON-BAHR, P. E. C. (1972). Leishmaniasis. In Manson's Tropical Diseases, eds Willcocks, C. & Manson-Bahr, P. E. C. pp. 117-147. London: Bailliere Tindal.
10. OLLIARO, P. L. & BRYCESON, A. D. M. (1993). Practical progress and new drugs for changing patterns of leishmaniasis. Parasitology Today, 9, 323-328.
11. OZSOYLU, U. S. (1996). Treatment of kala-azar. Lancet, i, 1701.
12. PETERS, W. (1981). The treatment of kala-azar, the new approaches to an old problem. Indian Journal of Medical Research, 73 (Suppl.), 1-18.
13. ROSE, S. A. & BLACKBURN, H. (1968). Cardiovascular Survey Methods. Geneva: World Health Organization.
14. SUNDAR, S. (1997). Treatment of visceral leishmaniasis - current status. Journal of the Association of Physicians of India, 45, 640-647.
15. SUNDAR, S., ROSENKAIMER, F., LESSER, M. L. & MURRAY, H. W. (1995). Immunochemotherapy for a systemic intracellular infection: accelerated response using interferon-γ in visceral leishmaniasis. Journal of Infectious Diseases, 171, 992-996.
16. THAKUR, C. P. (1984). Epidemiological, clinical and therapeutic features of Bihar kala-azar (including post kala-azar dermal leishmaniasis). Transactions of the Royal Society of Tropical Medicine and Hygiene, 78, 391-398.
17. THAKUR, C. P. (1986). Harmful effect of high stibogluconate treatment of kala-azar in India. Transactions of the Royal Society of Tropical Medicine and Hygiene, 80, 672-673.
18. THAKUR, C. P., KUMAR, M., SINGH, S. K., SHARMA, D., PRASAD, U. S., SINGH, R. S. P., DHAWAN, P. S. & ACHARI, V. (1984). Comparison of regimens of treatment with sodium stibogluconate in kala-azar. British Medical Journal, ii, 895-897.
19. THAKUR, C. P., KUMAR, M., KUMAR, P., MISHRA, B. N. & PANDEY, A. K. (1988). Rationalisation of regimens of treatment of kala-azar with sodium stibogluconate in India: a randomised study. British Medical Journal, ii, 1557-1561.
20. THAKUR, C. P., KUMAR, M. & PANDEY, A. K. (1991). Evaluation of efficacy of longer durations of therapy of fresh cases of kala-azar with sodium stibogluconate. Indian Journal of Medical Research, 93, 103-110.
21. THAKUR, C. P., SINHA, G. P., SHARMA, V., PANDEY, A. K., KUMAR, M. & VERMA, B. B. (1993). Evaluation of amphotericin as a first line drug in comparison of sodium stibogluconate in the treatment of fresh cases of kala-azar. Indian Journal of Medical Research, 97, 170-175.
22. THAKUR, C. P., SISTER FRANCES, SISTER THERESE, SISTER VICTORIA & SISTER PUSHPA (1994). A kala-azar control programme for remote tribal communities. World Health Forum, 15, 245-247.
23. THAKUR, C. P., PANDEY, A. K., SINHA, G. P., ROY, S., BEHBEHANI, K. & OLLIARO, P. (1996a). Comparison of three treatment regimens with liposomal amphotericin B (Ambisome) for visceral leishmaniasis in India: a randomized dose-finding study. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 319-322.
24. THAKUR, C. P., SINHA, G. P. & PANDEY, A. K. (1996b). Comparison of regimens of amphotericin B deoxycholate in kala-azar. Indian Journal of Medical Research, 103, 259-263.
25. TUCKMAN, E. (1949). Treatment of Chinese kala-azar with sodium antimony gluconate. Journal of Tropical Medicine and Hygiene, 52, 149-240.
26. WORLD HEALTH ORGANIZATION (1982). Report of the Informal Meeting on the Chemotherapy of Visceral Leishmaniasis. Document TDR/Chem/Leish/VL/82.3. Geneva: WHO.
27. WORLD HEALTH ORGANIZATION (1990). Control of the Leishmaniases. Technical Report Series No. 793. Geneva: WHO.