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Volumn 2, Issue , 2002, Pages

Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer - A phase II study

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; IRINOTECAN; METHOTREXATE; OXALIPLATIN; PHOSPHORIBOSYL PYROPHOSPHATE; THYMIDYLATE SYNTHASE; ANTINEOPLASTIC AGENT;

EID: 19044368632     PISSN: 14712407     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2407-2-9     Document Type: Article
Times cited : (12)

References (48)
  • 1
    • 0032730143 scopus 로고    scopus 로고
    • Multicenter phase II study of bimonthly high-dose leucovorin, fluorouracil infusion, and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen
    • Andre T, Bensmaine MA, Louvet C, et al: Multicenter phase II study of bimonthly high-dose leucovorin, fluorouracil infusion, and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen. J Clin Oncol 1999, 17:3560-8
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3560-3568
    • Andre, T.1    Bensmaine, M.A.2    Louvet, C.3
  • 2
    • 0344783805 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers
    • Becouarn Y, Ychou M, Ducreux M, et al: Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers. J Clin Oncol 1998, 16:2739-44
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2739-2744
    • Becouarn, Y.1    Ychou, M.2    Ducreux, M.3
  • 3
    • 0031840201 scopus 로고    scopus 로고
    • Clinical efficacy of oxaliplatin monotherapy: Phase II trials in advanced colorectal cancer
    • Becouarn Y, Rougier P: Clinical efficacy of oxaliplatin monotherapy: phase II trials in advanced colorectal cancer. Semin Oncol 1998, 25:23-31
    • (1998) Semin. Oncol. , vol.25 , pp. 23-31
    • Becouarn, Y.1    Rougier, P.2
  • 4
    • 0004700371 scopus 로고    scopus 로고
    • Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: A phase II multicentric study
    • Diaz-Rubio E, Sastre J, Zaniboni A, et al: Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: a phase II multicentric study. Ann Oncol 1998, 9:105-8
    • (1998) Ann. Oncol. , vol.9 , pp. 105-108
    • Diaz-Rubio, E.1    Sastre, J.2    Zaniboni, A.3
  • 5
    • 0012797224 scopus 로고    scopus 로고
    • Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines
    • Machover D, Diaz-Rubio E, de Gramont A, et al: Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines. Ann Oncol 1996, 7:95-8
    • (1996) Ann. Oncol. , vol.7 , pp. 95-98
    • Machover, D.1    Diaz-Rubio, E.2    de Gramont, A.3
  • 6
    • 0033558004 scopus 로고    scopus 로고
    • A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
    • Rothenberg ML, Cox JV, DeVore RF, et al: A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma. Cancer 1999, 85:786-95
    • (1999) Cancer , vol.85 , pp. 786-795
    • Rothenberg, M.L.1    Cox, J.V.2    DeVore, R.F.3
  • 7
    • 0033005770 scopus 로고    scopus 로고
    • A phase III study of irinotecan (CPT-11) versus best supportive care in patients with metastatic colorectal cancer who have failed 5-fluorouracil therapy
    • V301 Study Group
    • Cunningham D, Glimelius B: A phase III study of irinotecan (CPT-11) versus best supportive care in patients with metastatic colorectal cancer who have failed 5-fluorouracil therapy. V301 Study Group. Semin Oncol 1999, 26:6-12
    • (1999) Semin. Oncol. , vol.26 , pp. 6-12
    • Cunningham, D.1    Glimelius, B.2
  • 8
    • 0031742312 scopus 로고    scopus 로고
    • Irinotecan in the first-line treatment of colorectal cancer
    • Saltz LB: Irinotecan in the first-line treatment of colorectal cancer. Oncology (Huntingt) 1998, 12:54-8
    • (1998) Oncology (Huntingt) , vol.12 , pp. 54-58
    • Saltz, L.B.1
  • 9
    • 0029919598 scopus 로고    scopus 로고
    • Irinotecan is an active agent in untreated patients with metastatic colorectal cancer
    • Conti JA, Kemeny NE, Saltz LB, et al: Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. J Clin Oncol 1996, 14:709-15
    • (1996) J. Clin. Oncol. , vol.14 , pp. 709-715
    • Conti, J.A.1    Kemeny, N.E.2    Saltz, L.B.3
  • 10
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • [see comments]
    • Moertel CG: Chemotherapy for colorectal cancer [see comments]. N Engl J Med 1994, 330:1136-42
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1136-1142
    • Moertel, C.G.1
  • 11
    • 0024342059 scopus 로고
    • Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: A randomized trial of the Northern California Oncology Group
    • Valone FH, Friedman MA, Wittlinger PS, et al: Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: a randomized trial of the Northern California Oncology Group. J Clin Oncol 1989, 7:1427-36
    • (1989) J. Clin. Oncol. , vol.7 , pp. 1427-1436
    • Valone, F.H.1    Friedman, M.A.2    Wittlinger, P.S.3
  • 12
    • 0024385167 scopus 로고
    • The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III trial
    • Gastrointestinal Tumor Study Group [published erratum appears in J Clin Oncol 1990 Jan; 8(1):185]
    • Petrelli N, Douglass HO Jr, Herrera L, et al: The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group [published erratum appears in J Clin Oncol 1990 Jan; 8(1):185]. J Clin Oncol 1989, 7:1419-26
    • (1989) J. Clin. Oncol. , vol.7 , pp. 1419-1426
    • Petrelli, N.1    Douglass Jr., H.O.2    Herrera, L.3
  • 13
    • 0029813416 scopus 로고    scopus 로고
    • Weekly high-dose leucovorin versus low-dose leucovorin combined with fluorouracil in advanced colorectal cancer: Results of a randomized multicenter trial
    • Study Group for Palliative Treatment of Metastatic Colorectal Cancer Study Protocol 1
    • Jager E, Heike M, Bernhard H, et al: Weekly high-dose leucovorin versus low-dose leucovorin combined with fluorouracil in advanced colorectal cancer: results of a randomized multicenter trial. Study Group for Palliative Treatment of Metastatic Colorectal Cancer Study Protocol 1. J Clin Oncol 1996, 14:2274-9
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2274-2279
    • Jager, E.1    Heike, M.2    Bernhard, H.3
  • 14
    • 0028219974 scopus 로고
    • Advanced Colorectal Cancer Meta-Analysis Project
    • Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer
    • Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer. Advanced Colorectal Cancer Meta-Analysis Project. J Clin Oncol 1994, 12:960-9
    • (1994) J. Clin. Oncol. , vol.12 , pp. 960-969
  • 15
    • 0024199545 scopus 로고
    • 5-Fluorouracil (FUra) and folinic acid (FA) therapy in patients with colorectal cancer
    • Erlichman C: 5-Fluorouracil (FUra) and folinic acid (FA) therapy in patients with colorectal cancer. Adv Exp Med Biol 1988, 244:185-92
    • (1988) Adv. Exp. Med. Biol. , vol.244 , pp. 185-192
    • Erlichman, C.1
  • 16
    • 0023874456 scopus 로고
    • A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma
    • Erlichman C, Fine S, Wong A, Elhakim T: A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 1988, 6:469-75
    • (1988) J. Clin. Oncol. , vol.6 , pp. 469-475
    • Erlichman, C.1    Fine, S.2    Wong, A.3    Elhakim, T.4
  • 17
    • 0025104965 scopus 로고
    • Biochemical modulation of 5-fluorouracil by PALA
    • O'Dwyer PJ: Biochemical modulation of 5-fluorouracil by PALA. Cancer Invest 1990, 8:261-2
    • (1990) Cancer Invest. , vol.8 , pp. 261-262
    • O'Dwyer, P.J.1
  • 18
    • 0027881623 scopus 로고
    • Biochemical modulation of 5-fluorouracil by PALA: Mechanism of action
    • Martin DS: Biochemical modulation of 5-fluorouracil by PALA: mechanism of action. Adv Exp Med Biol 1993, 339:153-63
    • (1993) Adv. Exp. Med. Biol. , vol.339 , pp. 153-163
    • Martin, D.S.1
  • 19
    • 0026763307 scopus 로고
    • Biochemical modulation of bolus fluorouracil by PALA in patients with advanced colorectal cancer
    • Kemeny N, Conti JA, Seiter K, et al: Biochemical modulation of bolus fluorouracil by PALA in patients with advanced colorectal cancer. J Clin Oncol 1992, 10:747-52
    • (1992) J. Clin. Oncol. , vol.10 , pp. 747-752
    • Kemeny, N.1    Conti, J.A.2    Seiter, K.3
  • 20
    • 0026609861 scopus 로고
    • Phase II trial of PALA in combination with 5-fluorouracil in advanced pancreatic cancer
    • Rosvold E, Schilder R, Walczak J, et al: Phase II trial of PALA in combination with 5-fluorouracil in advanced pancreatic cancer. Cancer Chemother Pharmacol 1992, 29:305-8
    • (1992) Cancer Chemother. Pharmacol. , vol.29 , pp. 305-308
    • Rosvold, E.1    Schilder, R.2    Walczak, J.3
  • 21
    • 0024992069 scopus 로고
    • Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer
    • O'Dwyer PJ, Paul AR, Walczak J, Weiner LM, Litwin S, Comis RL: Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer. J Clin Oncol 1990, 8:1497-503
    • (1990) J. Clin. Oncol. , vol.8 , pp. 1497-1503
    • O'Dwyer, P.J.1    Paul, A.R.2    Walczak, J.3    Weiner, L.M.4    Litwin, S.5    Comis, R.L.6
  • 22
    • 0025069140 scopus 로고
    • Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity
    • Kemeny NE, Schneider A, Martin DS: Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity. Cancer Invest 1990, 8:263-4
    • (1990) Cancer. Invest. , vol.8 , pp. 263-264
    • Kemeny, N.E.1    Schneider, A.2    Martin, D.S.3
  • 23
    • 0025606259 scopus 로고
    • Phase II study of fluorouracil and recombinant interferon alfa-2a in previously untreated advanced colorectal carcinoma
    • Pazdur R, Ajani JA, Patt YZ, et al: Phase II study of fluorouracil and recombinant interferon alfa-2a in previously untreated advanced colorectal carcinoma. J Clin Oncol 1990, 8:2027-31
    • (1990) J. Clin. Oncol. , vol.8 , pp. 2027-2031
    • Pazdur, R.1    Ajani, J.A.2    Patt, Y.Z.3
  • 24
    • 0031788827 scopus 로고    scopus 로고
    • Pharmacokinetics of recombinant human interferon-alpha 2a combined with 5-fluorouracil in patients with advanced colorectal carcinoma
    • Kim J, Zhi J, Satoh H, et al: Pharmacokinetics of recombinant human interferon-alpha 2a combined with 5-fluorouracil in patients with advanced colorectal carcinoma. Anticancer Drugs 1998, 9:689-96
    • (1998) Anticancer Drugs , vol.9 , pp. 689-696
    • Kim, J.1    Zhi, J.2    Satoh, H.3
  • 25
    • 0029923720 scopus 로고    scopus 로고
    • Phase III study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer
    • Hansen RM, Ryan L, Anderson T, et al: Phase III study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer. J Natl Cancer Inst 1996, 88:668-74
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 668-674
    • Hansen, R.M.1    Ryan, L.2    Anderson, T.3
  • 26
    • 7344243730 scopus 로고    scopus 로고
    • Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with weekly high-dose 48-hour continuous-infusion fluorouracil for advanced colorectal cancer: A Spanish Cooperative Group for Gastrointestinal Tumor Therapy (TTD) study
    • Aranda E, Diaz-Rubio E, Cervantes A, et al: Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with weekly high-dose 48-hour continuous-infusion fluorouracil for advanced colorectal cancer: a Spanish Cooperative Group for Gastrointestinal Tumor Therapy (TTD) study. Ann Oncol 1998, 9:727-31
    • (1998) Ann. Oncol. , vol.9 , pp. 727-731
    • Aranda, E.1    Diaz-Rubio, E.2    Cervantes, A.3
  • 27
    • 0031060206 scopus 로고    scopus 로고
    • Phase II study of UFT plus leucovorin in colorectal cancer
    • Pazdur R: Phase II study of UFT plus leucovorin in colorectal cancer. Oncology 1997, 54:19-23
    • (1997) Oncology , vol.54 , pp. 19-23
    • Pazdur, R.1
  • 28
    • 0026642174 scopus 로고
    • Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil, in CCRF-CEM cells
    • Romanini A, Li WW, Colofiore JR, Bertino JR: Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil, in CCRF-CEM cells. J Natl Cancer Inst 1992, 84:1033-8
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 1033-1038
    • Romanini, A.1    Li, W.W.2    Colofiore, J.R.3    Bertino, J.R.4
  • 29
    • 0027978971 scopus 로고
    • Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy
    • Kamm VJ, Rietjens IM, Vervoort J, et al: Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy. Cancer Res 1994, 54:4321-6
    • (1994) Cancer Res. , vol.54 , pp. 4321-4326
    • Kamm, V.J.1    Rietjens, I.M.2    Vervoort, J.3
  • 30
    • 0029039255 scopus 로고
    • Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: Potentiating or reversing effect?
    • Van der Wilt CL, Braakhuis BJ, Pinedo HM, De Jong M, Smid K, Peters GJ: Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect? Int J Cancer 1995, 61:672-8
    • (1995) Int. J. Cancer , vol.61 , pp. 672-678
    • Van der Wilt, C.L.1    Braakhuis, B.J.2    Pinedo, H.M.3    De Jong, M.4    Smid, K.5    Peters, G.J.6
  • 31
    • 0031944992 scopus 로고    scopus 로고
    • Biomodulation of Fluorouracil in colorectal cancer
    • [see comments]
    • Ardalan B, Luis R, Jaime M, Franceschi D: Biomodulation of Fluorouracil in colorectal cancer [see comments]. Cancer Invest 1998, 16:237-51
    • (1998) Cancer Invest. , vol.16 , pp. 237-251
    • Ardalan, B.1    Luis, R.2    Jaime, M.3    Franceschi, D.4
  • 32
    • 0026603804 scopus 로고
    • Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: A 19F-MRS study in vivo
    • McSheehy PM, Prior MJ, Griffiths JR: Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: a 19F-MRS study in vivo. Br J Cancer 1992, 65:369-75
    • (1992) Br. J. Cancer , vol.65 , pp. 369-375
    • McSheehy, P.M.1    Prior, M.J.2    Griffiths, J.R.3
  • 34
    • 0015962412 scopus 로고
    • Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
    • Santi DV, McHenry CS, Sommer H: Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry 1974, 13:471-81
    • (1974) Biochemistry , vol.13 , pp. 471-481
    • Santi, D.V.1    McHenry, C.S.2    Sommer, H.3
  • 35
    • 0023201849 scopus 로고
    • Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: Enhancement by leucovorin
    • Mini E, Moroson BA, Bertino JR: Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin. Cancer Treat Rep 1987, 71:381-9
    • (1987) Cancer Treat. Rep. , vol.71 , pp. 381-389
    • Mini, E.1    Moroson, B.A.2    Bertino, J.R.3
  • 36
    • 0020660706 scopus 로고
    • Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil
    • Yin MB, Zakrzewski SF, Hakala MT: Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil. Mol Pharmacol 1983, 23:190-7
    • (1983) Mol. Pharmacol. , vol.23 , pp. 190-197
    • Yin, M.B.1    Zakrzewski, S.F.2    Hakala, M.T.3
  • 37
    • 0018700143 scopus 로고
    • Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: Explanation for drug synergism
    • Cadman E, Heimer R, Davis L: Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism. Science 1979, 205:1135-7
    • (1979) Science , vol.205 , pp. 1135-1137
    • Cadman, E.1    Heimer, R.2    Davis, L.3
  • 38
    • 0019134597 scopus 로고
    • Schedule-dependent cytotoxicity of methotrexate and 5-fluorouracil in human colon and breast tumor cell lines
    • Benz C, Schoenberg M, Choti M, Cadman E: Schedule-dependent cytotoxicity of methotrexate and 5-fluorouracil in human colon and breast tumor cell lines. J Clin Invest 1980, 66:1162-5
    • (1980) J. Clin. Invest. , vol.66 , pp. 1162-1165
    • Benz, C.1    Schoenberg, M.2    Choti, M.3    Cadman, E.4
  • 39
    • 0003859172 scopus 로고
    • 5-fluorouracil-methotrexate synergy: Enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates
    • Fernandes DJ, Bertino JR: 5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates. Proc Natl Acad Sci U S A 1980, 77:5663-7
    • (1980) Proc. Natl. Acad. Sci. U. S. A. , vol.77 , pp. 5663-5667
    • Fernandes, D.J.1    Bertino, J.R.2
  • 40
    • 0031684654 scopus 로고    scopus 로고
    • Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: Elevated dTTP pools and enhanced cytotoxicity
    • Mullany S, Svingen PA, Kaufmann SH, Erlichman C: Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity. Cancer Chemother Pharmacol 1998, 42:391-9
    • (1998) Cancer Chemother. Pharmacol. , vol.42 , pp. 391-399
    • Mullany, S.1    Svingen, P.A.2    Kaufmann, S.H.3    Erlichman, C.4
  • 41
    • 0032032201 scopus 로고    scopus 로고
    • Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line
    • Guichard S, Hennebelle I, Bugat R, Canal P: Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line. Biochem Pharmacol 1998, 55:667-76
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 667-676
    • Guichard, S.1    Hennebelle, I.2    Bugat, R.3    Canal, P.4
  • 42
    • 3042740412 scopus 로고    scopus 로고
    • Mechanisms of the synergy between oxaliplatin (LOHP) and 5 fluorouracil (FU)-folinic acid (FA)
    • Rostagno P, Formento P, Ciccolini J, et al: Mechanisms of the synergy between oxaliplatin (LOHP) and 5 fluorouracil (FU)-folinic acid (FA). Proc. Amer. Assoc. Can. Res. 2000
    • (2000) Proc. Amer. Assoc. Can. Res.
    • Rostagno, P.1    Formento, P.2    Ciccolini, J.3
  • 43
    • 3042778056 scopus 로고    scopus 로고
    • Cytotoxicity of oxaliplatin in gastric cancer cells - Studies on single-agent activity and combination effect with 5-fluorouracil
    • Hsu C, Yeh KH, Yeh PY, Chen ML, Lin ZR, Cheng AL: Cytotoxicity of oxaliplatin in gastric cancer cells - Studies on single-agent activity and combination effect with 5-fluorouracil. Proc. Amer. Assoc. Can. Res. 2000
    • (2000) Proc. Amer. Assoc. Can. Res.
    • Hsu, C.1    Yeh, K.H.2    Yeh, P.Y.3    Chen, M.L.4    Lin, Z.R.5    Cheng, A.L.6
  • 44
    • 0033860324 scopus 로고    scopus 로고
    • Double modulation of 5-fluorouracil by leucovorin and low-dose methotrexate in advanced colorectal cancer
    • [In Process Citation]
    • Stabuc B, Markovic A, Plesnicar A, Cizej TE: Double modulation of 5-fluorouracil by leucovorin and low-dose methotrexate in advanced colorectal cancer [In Process Citation]. Neoplasma 2000, 47:248-52
    • (2000) Neoplasma. , vol.47 , pp. 248-252
    • Stabuc, B.1    Markovic, A.2    Plesnicar, A.3    Cizej, T.E.4
  • 45
    • 0033370189 scopus 로고    scopus 로고
    • Concurrent modulation of 5-fluorouracil with methotrexate and L-leucovorin: An effective and moderately toxic regimen for the treatment of advanced colorectal carcinoma
    • A multicenter phase II study of the Southern Italy Cooperative Oncology Group
    • Comella P, Lorusso V, Casaretti R, et al: Concurrent modulation of 5-fluorouracil with methotrexate and L-leucovorin: an effective and moderately toxic regimen for the treatment of advanced colorectal carcinoma. A multicenter phase II study of the Southern Italy Cooperative Oncology Group. Tumori 1999, 85:465-72
    • (1999) Tumori , vol.85 , pp. 465-472
    • Comella, P.1    Lorusso, V.2    Casaretti, R.3
  • 46
    • 9344239938 scopus 로고    scopus 로고
    • Biochemical modulation of fluorouracil: Comparison of methotrexate, folinic acid, and fluorouracil versus folinic acid and fluorouracil in advanced colorectal cancer: A randomized trial
    • Polyzos A, Tsavaris N, Giannopoulos A, et al: Biochemical modulation of fluorouracil: comparison of methotrexate, folinic acid, and fluorouracil versus folinic acid and fluorouracil in advanced colorectal cancer: a randomized trial. Cancer Chemother Pharmacol 1996, 38:292-7
    • (1996) Cancer Chemother. Pharmacol. , vol.38 , pp. 292-297
    • Polyzos, A.1    Tsavaris, N.2    Giannopoulos, A.3
  • 47
    • 0031891542 scopus 로고    scopus 로고
    • Double modulation of 5-fluorouracil by methotrexate and high-dose L-leucovorin in advanced colorectal cancer
    • Romero AO, Perez JE, Cuevas MA, et al: Double modulation of 5-fluorouracil by methotrexate and high-dose L-leucovorin in advanced colorectal cancer. Am J Clin Oncol 1998, 21:94-8
    • (1998) Am. J. Clin. Oncol. , vol.21 , pp. 94-98
    • Romero, A.O.1    Perez, J.E.2    Cuevas, M.A.3
  • 48
    • 0026100241 scopus 로고
    • The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer
    • [see comments]
    • Marsh JC, Bertino JR, Katz KH, et al: The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer [see comments]. J Clin Oncol 1991, 9:371-80
    • (1991) J. Clin. Oncol. , vol.9 , pp. 371-380
    • Marsh, J.C.1    Bertino, J.R.2    Katz, K.H.3


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