Double modulation of 5-fluorouracil by leucovorin and low-dose methotrexate in advanced colorectal cancer

Neoplasma

Volumn 47, Issue 4, 2000, Pages 248-252

  Stabuc, B ^a   Markovic, A ^a   Plesnicar, A ^a   Cizej, T E ^a  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

5 fluorouracil; Biochemical modulation; Colorectal cancer; Methotrexate

Indexed keywords

FLUOROURACIL; FOLINIC ACID; METHOTREXATE;

ADVANCED CANCER; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; DIARRHEA; DOSE RESPONSE; DRUG METABOLISM; ERYTHRODERMA; HUMAN; LEUKOPENIA; METASTASIS; NAUSEA; PHASE 2 CLINICAL TRIAL; PROGNOSIS; STOMATITIS; SURVIVAL RATE; VOMITING;

EID: 0033860324     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Sequential combination of methotrexate 5-fluorouracil and high-dose folinic acid in advanced colorectal cancer: Double biochemical modulation?
2. Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer
3. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
4. Biochemical modulation: A modality that has come of therapeutic age
5. Modulation of high-dose infusional 5-fluorouracil by low-dose methotrexate in patients with advanced or metastatic colorectal cancer: Final results of a randomized European Organisation for Research and Treatment of Cancer Study
6. Palliative chemotherapy in metastatic colorectal carcinoma: Comparison of two chemotherapeutic regimens
7. A confidence interval for the median survival time
8. MTX/5-FU trials in gastrointestinal and other cancers
9. Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: Explanation for drug synergism
10. Chemotherapy of large bowel cancer
11. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma
12. Biochemical modulation of 5-fluorouracil: A randomized comparison of sequential methotrexate, 5-fluorouracil and leucovorin versus sequential 5-fluorouracil and leucovorin in patients with advanced symptomatic colorectal cancer
13. The implications of tumour heterogeneity for studies on the biology and therapy of cancer metastases
14. Non-parametric estimation from incomplete observations
15. Activity of sequential low-dose methotrexate and fluorouracil in advanced colorectal carcinoma. Attempt at correlation with tissue and blood levels of phosphoribosylpyrophosphate
16. Folinic acid + 5-fluorouracil (5-FU) versus equidose 5-FU in advanced colorectal cancer: Phase III study of GISCAD (Italian Group for the Study of Digestive Tract Cancer)
17. The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer
18. Reporting results of cancer treatment
19. The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III1 trial
20. A prospective randomized trial of 5 fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma
21. Fluorouracil: Biochemistry and pharmacology
22. Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
23. Double modulation of 5-fluorouracil by methotrexate and high-dose L-leucovorin in advanced colorectal cancer
24. Treatment of patients with advanced colorectal carcinomas with fluorouracil alone high-dose leucovorin plus fluorouracil or sequential methotrexate fluorouracil and leucovorin: A randomized trial of the Northern California Oncology Group
25. Addition of leucovorin in modulation of 5-fluorouracil with methotrexate Potentiating or reversing effect?