Lack of relationship between vitamin D receptor genotype and forearm bone gain in healthy children, adolescents, and young adults

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 3, 1997, Pages 851-855

  Gunnes, Magnar ^a   Berg, Jens P ^b   Halse, Johan ^b,c   Lehmann, Egil H ^a  

^a Ctr for Clin Osteoporosis Research   (Norway)

^b AKER UNIVERSITY HOSPITAL   (Norway)

^c Osteoporosis Clinic   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DNA; VITAMIN D RECEPTOR;

ADOLESCENT; AGE; ALLELE; ARTICLE; BODY FAT; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; BONE MASS; BONE MINERAL; CALCIUM INTAKE; DNA POLYMORPHISM; FEMALE; FOREARM; GENOTYPE; HIP; HUMAN; MALE; NORMAL HUMAN; PHOTON ABSORPTIOMETRY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SCHOOL CHILD; SPINE; SUN EXPOSURE; WEIGHT BEARING;

ADOLESCENT; ADULT; AGING; BONE DENSITY; BONE DEVELOPMENT; CHILD; CHILD DEVELOPMENT; COHORT STUDIES; DENSITOMETRY, X-RAY; FEMALE; FOREARM; GENOTYPE; HUMANS; MALE; RECEPTORS, CALCITRIOL;

EID: 0031036611     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.3.851     Document Type: Article

References (36)

1. Pocock NA, Eisman JA, Hopper JL, Yeates PN, Sambrook PN, Ebert S. 1987 Genetic determinants of bone mass in adults: a twin study. J Clin Invest. 80:706-710.
2. Slemenda CW, Christian JC, Williams CJ, Norton JA, Johnston Jr CC. 1991 Genetic determinants of bone mass in adult women: a reevaluation of the twin model and potential importance of gene interaction on heritability estimates. J Bone Miner Res. 6:561-567.
3. Dequecker J, Nijs J, Vestraeten A, Geusens P, Gevers G. 1987 Genetic determinants of bone mineral content at the spine and radius: a twin study. Bone. 8:207-209.
4. Morrison NA, Qi JC, Tokita A, et al. 1994 Prediction of bone density from vitamin D receptor alleles. Nature. 367:284-287.
5. Spector TD, Keen RW, Arden NK, et al. 1995 Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain. Br Med J. 310:1357-60.
6. Fleet JM, Harris SS, Wood RJ, Dawson-Hughes B. 1995 The BsmI vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res. 10:985-990.
7. Riggs BL, Ngyen TV, Melton III LJ, et al. 1995 The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res. 10:991-996.
8. Ferrari S, Rizzoli R, Chevalley T, Slosman D, Eisman JA, Bonjour J-P. 1995 Vitamin-D-receptor-gene polymorphisms and change in lumbar spine bone mineral density. Lancet. 345:423-424.
9. Yamagata Z, Miyamura T, Iijima S, et al. 1994 Vitamin D receptor gene polymorphism and bone mineral density in healthy Japanese women. Lancet. 344:1027.
10. Hustmyer FG, Peacock M, Hui S, Johnston CC, Christian J. 1994 Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest. 94:2130-2134.
11. Melhus H, Kindmark A, Amér S, Wilén B, Lindh E, Ljunghall S. 1994 Vitamin D receptor genotypes in osteoporosis. Lancet. 344:949-950.
12. Garnero P, Borel O, Sornay-Rendu E, Delmas PD. 1995 Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. J Bone Miner Res. 10:1283-1288.
13. Looney JE, Yoon HK, Fischer M, et al. 1995 Lack of a high prevalence of the BB vitamin D receptor genotype in severely osteoporotic women. J Clin Endocrinol Metab. 80:2158-2162.
14. Garnero P, Borel O, Sornay-Rendu E, Arlo M, Delmas PD. 1996 Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss, and bone mass in postmenopausal women: the OFELY study. J Bone Miner Res. 11:827-834.
15. Garnero P, Arden NK, Griffiths G, Delmas PD, Spector TD. 1996 Genetic influence on bone turnover in postmenopausal twins. J Clin Endocrinol Metab. 81:140-146.
16. Gallagher JC, Goldgar D, Kinyamu H, Fannon P. 1994 Vitamin D receptor genotypes in type I osteoporosis. J Bone Miner Res 9:S143.
17. Krall EA, Parry P, Lichter JB, Dawson-Hughes B. 1995 Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake. J Bone Miner Res. 10:978-984.
18. Dawson-Hughes B, Harris SS, Finneran S. 1995 Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. J Clin Endocrinol Metab. 80:3657-3661.
19. Keen RW, Major PJ, Lanchbury JS, Spector TD. 1995 Vitamin-D-receptorgene polymorphism and bone loss. Lancet. 345:990.
20. Kröger H, Mahonen A, Ryhänen S, Turunen A-M, Alhava E, Mäenpää P. 1995 Vitamin D receptor genotypes and bone mineral density. Lancet. 345:1238.
21. Berg JP, Falch JA, Haug E. 1996 Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis. Eur J Endocrinol. 135:96-100.
22. Morrison NA, Yeoman R, Kelly PJ, Eisman JA. 1992 Contribution of transacting factor alleles to normal physiological variability: vitamin D receptor gene polymorphisms and circulating osteocalcin. Proc Natl Acad Sci USA. 89:6665-6669.
23. Shiraki M, Eguchi H, Aoki C, Shiraki Y. 1995 Can allelic variation in vitamin D receptor gene predict bone densities and serum osteocalcin level in Japanese women? Bone. 16:84S.
24. Peacock M, Hustmyer FG, Johnston CC, Christian J. Heritability of bone mass, bone turnover, calcium regulation and calcium absorption in relation to RFLPs at the vitamin D and PTH receptor genes. Bone. 16:83S.
25. Slemenda CW, Christian CJ, Reed TK, Williams CJ, Johnston Jr CC. 1992 Long-term bone loss in men: effects of genetic and environmental factors. Ann Intern Med. 117:286-291.
26. Ferrari SL, Rizzoli R, Theintz G, Slosman DO, Bonjour JP. 1995 Vitamin D-receptor (VDR) gene polymorphisms and the effect of calcium supplementation on bone mass accumulation in prepubertal girls. J Bone Miner Res 10:5187.
27. Klisovic D, Young AP, Ilich M, Skugor M, Badenhop N, Matkovic V. 1995 Vitamin D receptor polymorphism (VDR) and bone mineral density (BMD) in prepubertal females. J Bone Miner Res 10:S189.
28. Specker BL, Williams LA, Kalkwarf H, et al. 1995 Vitamin D receptor genotype and its relation to bone growth and bone mineralization in infants 3 to 12 months of age. J Bone Miner Res 10:S188.
29. Theintz G, Bucks B, Rizzoli R, et al. 1992 Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the level of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab. 75:1060-1065.
30. Gunnes M. 1994 Bone mineral density in the cortical and trabecular distal forearm in healthy children and adolescents. Acta Paediatr. 83:463-467.
31. Gunnes M, Lehmann EH. 1995 Dietary calcium, saturated fat, fiber and vitamin C as predictors of forearm cortical and trabecular bone mineral density in healthy children and adolescents. Acta Paediatr. 84:388-392.
32. Gunnes M, Lehmann EH. 1996 Physical activity and dietary constituents as predictors of forearm cortical and trabecular bone gain in healthy children and adolescents: a prospective study. Acta Paediatr. 85:19-25.
33. Schlenker RA, von Seggen WW. 1976 The distribution of cortical and trabecular bone mass along the lengths of the radius and ulna and the implications for the in vivo bone mass measurements. Calcif Tissue Res. 20:41-52.
34. Ngyen TV, Kelly PJ, Morrison NA, Sambrook PN, Eisman JA. 1994 Vitamin D receptor genotypes in osteoporosis. Lancet. 344:1580-1581.
35. Morrison NA, Jiang Q, Tokita A, Sambrook P, Kelly P, Eisman J. 1995 Genetic susceptibility and resistance to osteoporosis and vitamin D receptor gene. Bone. 16:83S.
36. Uitterlinden AG, Pols HAP, Burger H, et al. 1996 A large scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. J Bone Miner Res. 11:1241-1248.