Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms?

Journal of Bone and Mineral Research

Volumn 13, Issue 3, 1998, Pages 363-370

  Ferrari, S L ^a   Rizzoli, R ^a,b   Slosman, D O ^a   Bonjour, J P ^a  

^a UNIVERSITY HOSPITAL   (Switzerland)

^b Faculty of Medicine   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; VITAMIN D RECEPTOR;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; BONE DENSITY; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CHILD; CLINICAL TRIAL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; FEMUR; HUMAN; LUMBAR SPINE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; VITAMIN D METABOLISM;

ADOLESCENT; ADULT; AGING; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; CALCIUM, DIETARY; CHILD; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DIETARY SUPPLEMENTS; FEMALE; FEMUR; FEMUR NECK; GENOTYPE; HUMANS; LUMBAR VERTEBRAE; MIDDLE AGED; POLYMORPHISM, GENETIC; PREMENOPAUSE; PROSPECTIVE STUDIES; PUBERTY; RADIUS; RECEPTORS, CALCITRIOL; SWITZERLAND;

EID: 0031939187     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.3.363     Document Type: Article

References (38)

1. Morrison NA, Qi JC, Tokita A, Kelly PS, Crofts L, Nguyen TV, Sambrook PN, Eisman A 1994 Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287.
2. Spector TD, Keen RW, Arden NK, Morrison NA, Major PJ, Nguyen TV, Kelly PJ, Baker JR, Sambrook PN, Lanchbury JS, Eisman JA 1995 Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: A twin study in Britain. Br Med J 310:1357-1360.
3. Eisman JA 1995 Vitamin D receptor gene alleles and osteoporosis: An affirmative view. J Bone Miner Res 10:1289-1293.
4. Hustmyer FG, Peacock M, Hui S, Johnston CC, Christian J 1994 Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest 94:2130-2134.
5. Garnero P, Borel O, Sornay-Rendu E, Delmas P 1995 Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. J Bone Miner Res 10:1283-1286.
6. Berg JP, Falch JA, Haug E 1996 Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in high-endemic area of osteoporosis. Eur J Endocrinol 135:96-100.
7. Salamone LM, Glynn NW, Black DM, Ferrell R, Palermo L, Epstein RS, Kuller LH, Cauley JA 1996 Determinants of premenopausal bone mineral density: The interplay of genetic and lifestyle factors. J Bone Miner Res 11:1557-1565.
8. Looney JE, Yoon HK, Fisher M, Parley SM, Parley JR, Wergedal JE, Baylink DJ 1995 Lack of a high prevalence of the BB Vitamin D receptor genotype in severely osteoporotic women. J Clin Endocrinol Metab 80:2158-2162.
9. Peacock M 1995 Vitamin D receptor gene alleles and osteoporosis: A contrasting view. J Bone Miner Res 10:1294-1297.
10. Cooper GS, Umbach DM 1996 Are vitamin D receptor polymorphisms associated with bone mineral density? A metaanalysis. J Bone Miner Res 11:1835-1849.
11. Econs MJ, Speer MC 1996 Genetic studies of complex diseases: Let the reader beware. J Bone Miner Res 11:1835-1840.
12. Ferrari S, Rizzoli R, Chevalley T, Slosman D, Eisman JA, Bonjour JP 1995 Vitamin-D-receptor-gene polymorphisms and change in lumbar-spine bone mineral density. Lancet 345:423-424.
13. Krall EA, Parry P, Lichter JB, Dawson-Hughes B 1995 Vitamin D receptor alleles and rates of bone loss: Influences of years since menopause and calcium intake. J Bone Miner Res 10:978-984.
14. Bonjour JP, Carrie AL, Ferrari S, Clavien H, Slosman D, Theintz G, Rizzoli R 1997 Calcium-enriched foods and bone mass growth in prepubertal girls: A randomized, double-blind, placebo-controlled trial. J Clin Invest 99:1287-1294.
15. Bonjour JP, Theintz G, Law F, Slosman D, Rizzoli R 1991 Critical years and stages of puberty for spinal and femoral bone mass gain during adolescence. J Clin Endocrinol Metab 73: 555-563.
16. Theintz G, Buchs B, Rizzoli R, Slosman D, Clavien H, Sizonenko PC, Bonjour JP 1992 Longitudinal monitoring of bone mass accumulation in healthy adolescents: Evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab 75:1060-1065.
17. Slosman DO, Rizzoli R, Pichard C, Donath A, Bonjour JP 1994 Longitudinal measurement of regional and whole body bone mass in young healthy adults. Osteoporos Int 4:185-190.
18. Smith DA, Nance WE, Won Kang K, Christian JC, Johnston CC 1973 Genetic factors in determining bone mass. J Clin Invest 52:2800-2808.
19. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberi S 1987 Genetic determinants of bone mass in adults. J Clin Invest 80:706-710.
20. Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G 1987 Genetic determinants of bone mineral content at the spine and the radius: A twin study. Bone 8:207-209.
21. Krall EA, Dawson-Hughes B 1993 Heritable and life-style determinants of bone mineral density. J Bone Miner Res 8:1-9.
22. Kelly PJ, Morrison NA, Sambrook PN, Nguyen TV, Eisman JA 1995 Genetic influences on bone turnover bone density and fracture. Eur J Endocrinol 133:265-271.
23. Riggs BL, Nguyen TV, Melton LJ III, Morrison NA, O'Fallon WM, Kelly PJ, Egan KS, Sambrook PN, Muhs JM, Eisman JA 1995 The contribution of Vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 10:991-996.
24. Fleet JC, Harris SS, Wood RJ, Dawson-Hughes B 1995 The BsmI vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res 10:985-990.
25. Sainz J, Van Tornout JM, Loro L, Sayre J, Roe TF, Gilsanz V 1997 Vitamin D-receptor gene polymorphisms and bone density in prepubertal American girls of Mexican descent. N Engl J Med 337:77-81.
26. Prentice A, Parsons TJ, Cole TJ 1994 Uncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants. Am J Clin Nutr 60:837-842.
27. Lloyd T, Andon MB, Rollings N, Martel SK, tandis SR, Deniers CM, Eggli DF, Kieselhorst K, Kulin ME 1993 Calcium supplementation and bone mineral density in adolescent girls. JAMA 270:841-844.
28. Lloyd T, Martel JK, Rollings N, Andon MB, Kulin H, Demers LM, Eggli DF, Kieselhorst K, Chinchilli VM 1996 The effect of calcium supplementation and Tanner stage on bone density, content and area in teenage women. Osteoporos Int 6:276-283.
29. Johnston CC, Miller JZ, Slemenda CW, Reister TK, Hui S, Christian SC, Peacook M 1992 Calcium supplementation and increases in bone mineral density in children. N Engl J Med 327:82-87.
30. Lee WTK, Leung SSF, Wang SH, Xu YC, Zeng WP, Lau P, Oppenheimer SJ, Cheng SCY 1994 Double-blind, controlled calcium supplementation and bone mineral accretion in children accustomed to a low-calcium diet. Am J Clin Nutr 60: 744-750.
31. National Institutes of Health 1994 Optimal calcium intake. NIH Consensus Statement 12:1-31.
32. Dawson-Hughes B, Harris SS, Finneran S 1995 Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. J Clin Endocrinol Metab 80:3657-3661.
33. Dawson-Hughes B 1991 Calcium-supplementation and bone loss: A review of controlled clinical trials. Am J Clin Nutr 54:2748-2808.
34. Matkovic V, Fontana D, Tominac C, Goel P, Chesnut IIICH 1990 Factors that influence peak bone mass formation: A study of calcium balance and the inheritance of bone mass in adolescent females. Am J Clin Nutr 52:878-888.
35. Gregg EW, Wolf RL, Kriska AM, Ferrell RE, Salamone LM, Black D, Kuller LH, Cauley JA 1996 Does the relationship between vitamin D receptor genotypes and bone parameters vary with physical activity level? J Bone Miner Res 11 (Suppl 1):S210.
36. Matkovic V, Ilich JZ, Skugor M, Badenhop N, An B, Vereault D, Rosen CJ, Young AP 1996 Vitamin-D receptor gene (VDR) polymorphism differentiates insulin-like growth factor-I (IGF-I) and body composition during growth. J Bone Miner Res 11 (Suppl 1):S209.
37. Kanis JA 1994 Calcium nutrition and its implications for osteoporosis: Part I. Children and healthy adults. Eur J Clin Nutr 48:757-767.
38. Chevalley T, Rizzoli R, Nydegger V, Slosman D, Rapin CH, Michel JP, Vasey H, Bonjour JP 1994 Effect of calcium supplements on femoral bone density and vertebral fracture rate in vitamin D-replete elderly patients. Osteoporos Int 4:245-252.