Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 25, Issue 6, 2005, Pages 685-693

  Suzuki, Shigeaki ^a   Yamashita, Toru ^a   Tanaka, Kortaro ^a   Hattori, Hidenori ^a   Sawamoto, Kazunobu ^a   Okano, Hideyuki ^a   Suzuki, Norihiro ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Gp130; Ischemia; Leukemia inhibitory factor; Neuroprotection; Stat3

Indexed keywords

CARDIOTROPHIN 1; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 11; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROTROPHIC FACTOR; ONCOSTATIN M; PHOSPHATE BUFFERED SALINE; PROTEIN KINASE B; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN INJURY; BRAIN ISCHEMIA; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNOHISTOCHEMISTRY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SPINAL CORD INJURY;

ANIMALS; ANTIGENS, CD; APOPTOSIS; BRAIN ISCHEMIA; CELL SURVIVAL; CYTOKINE RECEPTOR GP130; CYTOKINES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MALE; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOKINE; RECEPTORS, OSM-LIF; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 18944384555     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600061     Document Type: Article

References (33)

1. Acalovschi D, Wiest T, Hartmann M, Farahmi M, Mansmann U, Auffarth GU, Grau AJ, Green FR, Grond-Ginsbach C, Schwaninger M (2003) Multiple levels of regulation of the interleukin-6 system in stroke. Stroke 34:1864-70
2. Alonzi T, Middleton G, Wyatt S, Buchman V, Betz UAK, Müller W, Musiani P, Poli V, Davies AM (2001) Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol Cell Neurosci 18:270-82
3. Battle TE, Frank DA (2002) The role of STATs in apoptosis. Curr Mol Med 2:381-92
4. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-6
5. Belayev L, Alonso OF, Busto R, Zhoa W, Ginsberg MD (1996) Middle cerebral artery occlusion in the rat by intraluminal suture, neurological and pathological evaluation of an improved model. Stroke 27:1616-23
6. Blesch A, Uy HS, Grill RJ, Cheng JG, Patterson PH, Tuszynski MH (1999) Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury. J Neurosci 19:3556-66
7. Butzkueven H, Zhang JG, Soilu-Hanninen M, Hochrein H, Chionh F, Shipham KA, Emery B, Turnley AM, Petratos S, Ernst M, Bartlett PF, Kilpatrick TJ (2002) LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nat Med 8:613-9
8. Choi JS, Kim SY, Cha JH, Choi YS, Sung KW, Oh ST, Kim ON, Chung JW, Chun MH, Lee SB, Lee MY (2003) Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia. Glia 41:237-46
9. Getchell TV, Shah DS, Partin JV, Subhedar NK, Getchell ML (2002) Leukemia inhibitory factor mRNA expression is upregulated in macrophages and olfactory receptor neurons after target ablation. J Neurosci Res 67:246-54
10. Guo X, Chandrasekaren V, Lein P, Kaplan PL, Higgins D (1999) Leukemia inhibitory factor and cilliary neurotrophic factor cause dendritic retraction in cultured rat sympathetic neurons. J Neurosci 19:2113-21
11. Haas CA, Hofmann HD, Kirsch M (1999) Expression of CNTF/LIF-receptor components and activation of STAT3 signaling in axotomized facial motoneurons: evidence for a sequential postlesional function of the cytokines. J Neurobiol 41:559-71
12. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374:1-20
13. Hermann DM, Kilic E, Kugler S, Isenmann S, Bahn M (2001) Adenovirus-mediated GDNF and CNTF pretreatment protects against striatal injury following transient middle cerebral artery occlusion in mice. Neurobiol Dis 8:655-66
14. Herrmann O, Tarabin V, Suzuki S, Attigah N, Coserea I, Schneider A, Vogel J, Prinz S, Schwab S, Monyer H, Brombacher F, Schwaninger M (2003) Regulation of body temperature and neuroprotection by endogeneous interleukin-6 in cerebral ischemia. J Cereb Blood Flow Metab 23:406-15
15. Hilton DJ (1992) LIF: lots of interesting functions. Trends Biochem Sci 17:72-6
16. Justicia C, Gabriel C, Planas AM (2000) Activation of the JAK/STAT pathway following transient focal cerebral ischemia: signaling through Jak1 and Stat3 in astrocytes. Glia 30:253-70
17. Li M, Sendtner M, Smith A (1995) Essential function of LIF receptor in motor neurons. Nature 378:724-7
18. Lin TN, Wang PY, Chi SI, Kuo JS (1998) Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor α. (CNTFα) expression following focal cerebral ischemia. Mol Brain Res 55:71-80
19. Loddick SA, Turnbull AV, Rothwell NJ (1998) Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 18:176-9
20. Londreth GE (1999) Growth factors. In: Basic neurochemistry (Siegel GJ, eds), Philadelphia: Lippincott-Raven, 383-98
21. Memezawa H, Smith ML, Siesjo BK (1992) Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 23:552-9
22. Morikawa Y, Tohya K, Tamura S, Ichihara M, Miyajima A, Senba E (2000) Expression of interleukin-6 receptor, leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar Purkinje cells. Neuroscience 100:841-8
23. Nakashima K, Wiese S, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Yoshida K, Kishimoto T, Sendtner M, Taga T (1999) Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. J Neurosci 19:5429-34
24. Park JI, Strock CJ, Ball DW, Nelkin BD (2003) The Ras/Raf/MEK/ extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. Mol Cell Biol 23:543-54
25. Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates. Compact 3rd edn. San Diego: Academic Press
26. Shimazaki T, Shingo T, Weiss S (2001) The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells. J Neurosci 21:7642-53
27. Suzuki S, Tanaka K, Nogawa S, Nagata E, Ito D, Dembo T, Fukuuchi Y (1999) Temporal profile and cellular localization of interleukin-6 protein after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 19:1256-62
28. Suzuki S, Tanaka K, Nogawa S, Ito D, Dembo T, Kosakai A, Fukuuchi Y (2000) Immunohistochemical detection of leukemia inhibitory factor after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 20:661-8
29. Suzuki S, Tanaka K, Nogawa S, Dembo T, Kosakai A, Fukuuchi Y (2001) Phosphorylation of signal transducer and activator of transcription-3 (Stat3) after focal cerebral ischemia in rats. Exp Neurol 170:63-71
30. Tham S, Dowsing B, Finkelstein D, Donato R, Cheema SS, Bartlett PF, Morrison WA (1997) Leukemia inhibitory factor enhances the regeneration of transected rat sciatic nerve and the function of reinnervated muscle. J Neurosci Res 47:208-15
31. Watanabe D, Yoshimura R, Khalil M, Yoshida K, Kishimoto T, Taga T, Kiyama H (1996) Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain. Eur J Neurosci 8:1630-40
32. Wen TC, Peng H, Hata R, Desaki J, Sakanaka M (2001) Induction of phosphorylated-Stat3 following focal cerebral ischemia in mice. Neurosci Lett 303:153-6
33. Yamakuni H, Minami M, Satoh M (1996) Localization of mRNA for leukemia inhibitory factor receptor in the adult rat brain. J Neuroimmunol 70:189-98