Synthesis of 2,4-diamino-1,3,5-triazine analogues of methotrexate with potential antitumor activity

Polish Journal of Chemistry

Volumn 79, Issue 4, 2005, Pages 739-748

  Saczewski F ^a   Bulakowska A ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

2,4 diamino 1,3,5 triazines; Classical antifolate analogues; Synthesis

Indexed keywords

4 [[[2 AMINO 4 (MORPHOLINO) 1,3,5 TRIAZIN 6 YL]METHYL]AMINO]BENZOYL] GLUTAMIC ACID; 4 AMINOBENZOIC ACID; [4 [[[2 AMINO 4 (3,5,5 TRIMETHYLPYRAZOLIN 2 YL) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO]BENZOYL]ASPARTIC ACID; [4 [[[2 AMINO 4 (3,5,5 TRIMETHYLPYRAZOLIN 2 YL) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO]BENZOYL]GLUTAMIC ACID; [4 [[[2 AMINO 4 (3,5,5 TRIMETHYLPYRAZOLIN 2 YL) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO]BENZOYL]METHIONINE; [4 [[[2 AMINO 4 (N METHYLANILINO) 1,3,5 TRIAZIN 6 YL]METHYL]AMINO]BENZOYL] GLUTAMIC ACID; [4 [[[2 AMINO 4 (N PHENYLPIPERAZINO) 1,3,5 TRIAZIN 6 YL]METHYL]AMINO] BENZOYL]METHIONINE; [4 [[[2 AMINO 4 (N PHENYLPIPERAZINO) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO] BENZOYL]METHIONINE; [4 [[[2 AMINO 4 (PYRROLIDINO) 1,3,5 TRIAZIN 6 YL]METHYL]AMINO]BENZOYL] METHIONINE; [4 [[[2 AMINO 4 (PYRROLIDINO) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO] BENZOYL]METHIONINE; ASPARTIC ACID; DIMETHYL[4 [[[2 AMINO 4 (3,5,5 TRIMETHYLPYRAZOLIN 2 YL) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO]BENZOYL]ASPARTATE; DIMETHYL[4 [[[2 AMINO 4 (3,5,5 TRIMETHYLPYRAZOLIN 2 YL) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO]BENZOYL]GLUTAMATE; DIMETHYL[4 [[[2 AMINO 4 (N METHYLANILINO) 1,3,5 TRIAZIN 6 YL]METHYL]AMINO]BENZOYL]GLUTAMATE; ESTER DERIVATIVE; ETHYL[4 [[[2 AMINO 4 (MORPHOLINO) 1,3,5 TRIAZIN 6 YL]METHYL]AMINO]BENZOYL] GLUTAMATE; GLUTAMIC ACID; METHIONINE DERIVATIVE; METHOTREXATE DERIVATIVE; METHYL[4 [[(2 AMINO 4 PYRROLIDINO 1,3,5 TRIAZIN 6 YL)METHYL]METHYLAMINO] BENZOYL]METHIONINATE; METHYL[4 [[[2 AMINO 4 (3,5,5 TRIMETHYLPYRAZOLIN 2 YL) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO]BENZOYL]METHIONINATE; METHYL[4 [[[2 AMINO 4 (N PHENYLPIPERAZINO) 1,3,5 TRIAZIN 6 YL]METHYL]AMINO]BENZOYL]METHIONINATE; METHYL[4 [[[2 AMINO 4 (N PHENYLPIPERAZINO) 1,3,5 TRIAZIN 6 YL]METHYL]METHYLAMINO]BENZOYL]METHIONINATE; METHYL[4 [[[2 AMINO 4 (PYRROLIDINO) 1,3,5 TRIAZIN 6 YL]METHYL]AMINO] BENZOYL]METHIONINATE; PTERIDINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CONJUGATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; PANCREAS CANCER; SAPONIFICATION;

EID: 18844451239     PISSN: 01375083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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