Derivatives of 4,6-diamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a] quinoxalin-2H-1-one: Potential antagonist ligands for imaging the A2A adenosine receptor by positron emission tomography (PET)

European Journal of Medicinal Chemistry

Volumn 40, Issue 5, 2005, Pages 421-437

  Holschbach, Marcus H ^a   Bier, Dirk ^a   Wutz, Walter ^a   Sihver, Wiebke ^a   Schuller M ^a   Olsson, Ray A ^a,b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

A2A adenosine receptor antagonists; PET; Radioligands; Triazolo 4,3 a quinoxoline

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINO 6 (2 FLUORO 2 PHENYLETHYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (2 FLUORO 4 HYDROXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (2 FLUORO 4 METHOXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (2 FLUORO 5 METHOXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (2 FLUOROBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (2 HYDROXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (2 METHOXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (2 PHENYLETHYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (3 FLUOROBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (3 HYDROXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (3 METHOXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (4 FLUOROBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (4 HYDROXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (4 METHOXYBENZYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (5 BROMOFURAN 2 YLMETHYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 (5 IODOFURAN 2 YLMETHYLAMINO) 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 [4 (2 FLUORO 2 PHENYLETHYLAMINO)] 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 [4 (2 FLUOROETHOXY)BENZYLAMINO] 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 [4 (2 PHENYLETHYLAMINO)] 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 BENZYLAMINO 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINO 6 FURAN 2 YLMETHYLAMINO 2 PHENYL 2H [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4,6 DIAMINO 1,2 DIHYDRO 2 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALIN 2H 1 ONE DERIVATIVE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR ANTAGONIST; NANOPARTICLE; RADIOLIGAND; UNCLASSIFIED DRUG;

ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DERIVATIZATION; DIAGNOSTIC IMAGING; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; ISOTOPE LABELING; LIGAND BINDING; MOLECULAR INTERACTION; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RECEPTOR AFFINITY;

ANIMALS; AUTORADIOGRAPHY; BINDING, COMPETITIVE; BRAIN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; QUINOXALINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A2A; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRIAZOLES; TRITIUM;

EID: 18844438125     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.12.005     Document Type: Article

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