The D-methyl group in β-lactamase evolution: Evidence from the Y221G and GC1 mutants of the class C β-lactamase of Enterobacter cloacae P99

Biochemistry

Volumn 44, Issue 20, 2005, Pages 7543-7552

  Adediran, S A ^a   Zhang, Zhen ^b   Nukaga, Michiyoshi ^c   Palzkill, Timothy ^b   Pratt, R F ^a  

^a WESLEYAN UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Josai International University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYSIS; ENZYMES; HYDROPHOBICITY; SUBSTRATES;

ACYL TRANSFER; ACYL-ENZYMES; BACTERIAL CELLS;

BIOCHEMISTRY;

ALANINE; BETA LACTAMASE; DEXTRO ALANINE; GLYCINE; METHYL GROUP; PEPTIDASE; SERINE; TYROSINE;

AMINOLYSIS; ARTICLE; BACTERIUM MUTANT; CONFORMATION; CONTROLLED STUDY; ENTEROBACTER CLOACAE; ENZYME ACTIVITY; GENE MUTATION; HYDROLYSIS; HYDROPHOBICITY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; WILD TYPE;

BETA-LACTAMASES; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; ENTEROBACTER CLOACAE; EVOLUTION, MOLECULAR; GLYCINE; HYDROLYSIS; MODELS, MOLECULAR; SEQUENCE DELETION; SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE; THERMODYNAMICS; TYROSINE;

BACTERIA (MICROORGANISMS); ENTEROBACTER CLOACAE; STREPTOMYCES;

EID: 18844428364     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050136f     Document Type: Article

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