Heinz body hemolytic anemia with eccentrocytosis from ingestion of Chinese chive (Allium tuberosum) and garlic (Allium sativum) in a dog

Journal of the American Animal Hospital Association

Volumn 41, Issue 1, 2005, Pages 68-73

  Yamato, Osamu ^a   Kasai, Ei ^a   Katsura, Taro ^b   Takahashi, Shinichi ^b   Shiota, Takuji ^a   Tajima, Motoshi ^c   Yamasaki, Masahiro ^a   Maede, Yoshimitsu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Katsura Veterinary Hospital   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; FAMOTIDINE; METHEMOGLOBIN; MINERAL; ORBIFLOXACIN; RECOMBINANT ERYTHROPOIETIN; RINGER LACTATE SOLUTION; VITAMIN; VITAMIN B COMPLEX;

ANOREXIA; ARTICLE; BLOOD ANALYSIS; BLOOD CELL COUNT; CHINESE; CHIVE; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPRESSION; DIAGNOSTIC VALUE; DIARRHEA; DISEASE ASSOCIATION; DOG DISEASE; ERYTHROCYTE DISORDER; GARLIC; HEINZ BODY ANEMIA; HEMATOLOGIC DISEASE; HEMOLYSIS; HOSPITAL ADMISSION; INGESTION; LABORATORY TEST; LEUKOCYTOSIS; MALE; MEAN CORPUSCULAR HEMOGLOBIN; NEPHROSIS; NEUTROPHILIA; NONHUMAN; OXIDATIVE STRESS; PHYSICAL EXAMINATION; RECTUM TEMPERATURE; REFERENCE VALUE; STOMACH ULCER; SUPERINFECTION; URINALYSIS; VETERINARY MEDICINE; VOMITING;

ALLIUM; ALLIUM SATIVUM; ALLIUM SCHOENOPRASUM; ALLIUM TUBEROSUM; CANIS FAMILIARIS;

EID: 18844405794     PISSN: 15473317     EISSN: 15473317     Source Type: Journal    
DOI: 10.5326/0410068     Document Type: Article

References (32)

1. Desnoyers M. Anemias associated with Heinz bodies. In: Feldman BF, Zinkl JG, Jain NC, eds. Schalm's Veterinary Hematology. 5th ed. Philadelphia: Lippincott Williams and Wilkins, 2000:178-184.
2. Harvey JW. The erythrocyte: physiology, metabolism, and biochemical disorders. In: Kaneko JJ, Harvey JW, Bruss MJ, eds. Clinical Biochemistry of Domestic Animals. 5th ed. San Diego: Academic Press, 1995:157-203.
3. Lee KW, Yamato O, Tajima M, et al. Hematologic changes associated with the appearance of eccentrocytes after intragastric administration of garlic extract to dogs. Am J Vet Res 2000;61:1446-1450.
4. James LF, Binns W. Effects of feeding wild onions (Allium validum) to bred ewes. J Am Vet Med Assoc 1966;149:512-514.
5. Stevens H. Suspected wild garlic poisoning in sheep (lett). Vet Rec 1984;115:363.
6. Pierce KR, Joyce JR, England RB, et al. Acute hemolytic anemia caused by wild onion poisoning in horses. J Am Vet Med Assoc 1972;160:323-327.
7. Brewster JL. The classification, origins, distribution and economic importance of the major vegetable crops. In: Onions and Other Vegetable Alliums. Wallingford: CAB International, 1994:1-18.
8. Hegesh E, Gruener N, Cohen S, et al. A sensitive micromethod for the determination of methemoglobin in blood. Clin Chem Acta 1970;30:679-682.
9. Beutler E. Red Cell Metabolism. A Manual of Biochemical Methods. 3rd ed. Orlando: Grune & Stratton, 1984.
10. Parpart AK, Lorenz PB, Parpart ER, et al. The osmotic resistance (fragility) of human red cells. J Clin Invest 1947;26:636-641.
11. Okabe J, Tajima S, Yamato O, et al. Hemoglobin types, erythrocyte membrane skeleton and plasma iron concentration in calves with poikilocytosis. J Vet Med Sci 1996;58:629-634.
12. Harley JD, Mauer AM. Studies on the formation of Heinz bodies. I. Methemoglobin production and oxyhemoglobin destruction. Blood 1960;16:1722-1735.
13. Harley JD, Mauer AM. Studies on the formation of Heinz bodies. II. The nature and significance of Heinz bodies. Blood 1961;17:418-433.
14. Lubin A, Desforges JF. Effect of Heinz bodies on red cell deformability. Blood 1972;39:658-665.
15. Rifkind RA. Heinz body anemia: an ultrastructural study. II. Red cell sequestration and destruction. Blood 1965;26:433-448.
16. Ham TH, Grauel JA, Dunn RF, et al. Physical properties of red cells as related to effects in vivo. IV. Oxidant drugs producing abnormal intracellular concentration of hemoglobin (eccentrocytes) with a rigid-red-cell hemolytic syndrome. J Lab Clin Med 1973;82:898-910.
17. Fischer TM, Meloni T, Pescarmona GP, et al. Membrane cross bonding in red cells of favic crisis: a missing link in the mechanism of extravascular haemolysis. Br J Haematol 1985;59:159-169.
18. Fischer TM. Transcellular cross bonding of red blood cell membrane. Biochem Biophys Acta 1986;861:277-286.
19. Fischer TM. Role of spectrin in cross bonding of the red cell membrane. Blood Cells 1988;13:377-394.
20. Harvey JW, French TW, Senior DF. Hematologic abnormalities associated with chronic acetaminophen administration in a dog. J Am Vet Med Assoc 1986;189:1334-1335.
21. Harvey JW, Rachear D. Experimental onion-induced hemolytic anemia in dogs. Vet Pathol 1985;22:387-392.
22. Gruhzit OM. II. Anemia in dogs produced by feeding disulphide compounds. Am J Med Sci 1931;181:815-820.
23. Yamato O, Yoshihara T, Ichihara A, et al. Novel Heinz body hemolysis factors in onion (Allium cepa). Biosci Biotechnol Biochem 1994;58:221-222.
24. Yamato O, Sugiyama Y, Matsuura H, et al. Isolation and identification of sodium 2-propenyl thiosulfate from boiled garlic (Allium sativum) that oxidizes canine erythrocytes. Biosci Biotechnol Biochem 2003;67:1594-1596.
25. Hu Q, Yang Q, Yamato O, et al. Isolation and identification of organosulfur compounds oxidizing canine erythrocytes from garlic (Allium sativum). J Agric Food Chem 2002;50:1059-1062.
26. Yang Q, Hu Q, Yamato O, et al. Organosulfur compounds from garlic (Allium sativum) oxidizing canine erythrocytes. Z Naturforsch 2003;58c:408-412.
27. Brewster JL. The biochemistry and food science of Alliums. In: Onions and Other Vegetable Alliums. Wallingford: CAB International, 1994:203-212.
28. Yamato O, Maede Y. Susceptibility to onion-induced hemolysis in dogs with hereditary high erythrocyte reduced glutathione and potassium concentrations. Am J Vet Res 1992;53:134-137.
29. Yamato O, Lee KW, Chang HS, et al. Relation between erythrocyte reduced glutathione and glutamate concentration in Korean Jindo dogs with erythrocytes possessing hereditary high activity of Na-K-ATPase and a high concentration of potassium. J Vet Med Sci 1999;61:1179-1182.
30. Yamato O, Hayashi M, Yamasaki M, et al. Induction of onion-induced haemolytic anaemia in dogs with sodium n-propylthiosulphate. Vet Rec 1998;142:216-219.
31. Yamato O, Hayashi M, Kasai E, et al. Reduced glutathione accelerates the oxidative damage produced by sodium n-propylthiosulfate, one of the causative agents of onion-induced hemolytic anemia in dogs. Biochem Biophys Acta 1999;1427:175-182.
32. Chiu D, Lubin B, Shohet SB. Protective systems against peroxidation in red blood cells. In: Pryor WA, ed. Free Radicals in Biology. Vol. V. San Diego: Academic Press, 1982:128-136.