Increased N-acetylaspartate in rat striatum following long-term administration of haloperidol

Schizophrenia Research

Volumn 75, Issue 2-3, 2005, Pages 303-308

  Harte, M K ^a   Bachus, S B ^b   Reynolds, G P ^a,c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b GEORGE MASON UNIVERSITY   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Antipsychotics; N acetylaspartate; Postmortem; Schizophrenia

Indexed keywords

HALOPERIDOL DECANOATE; N ACETYLASPARTIC ACID; NEUROLEPTIC AGENT;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN TISSUE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CORPUS STRIATUM; FRONTAL CORTEX; FROZEN SECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; STATISTICAL SIGNIFICANCE; TEMPORAL CORTEX; THALAMUS; TISSUE LEVEL;

ANIMALS; ANTIPSYCHOTIC AGENTS; ASPARTIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, LONG-EVANS; TIME FACTORS;

EID: 18844385201     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2004.11.001     Document Type: Article

References (45)

1. R.J. Baldessarini, J.D. Hegarty, E.D. Bird, and F.M. Benes Meta-analysis of post-mortem studies of Alzheimer's disease-like neuropathology in schizophrenia Am. J. Psychiatry 154 1997 861 863
2. M.H. Baslow N-acetylaspartate in the vertebrate brain: metabolism and function Neurochem. Res. 28 2003 941 953
3. F.M. Benes, P.A. Paskevich, J. Davidson, and V.B. Domesick The effects of haloperidol on synaptic patterns in the rat striatum Brain Res. 329 1985 265 274
4. A. Bertolino, J.H. Callicott, I. Elman, V.S. Mattay, G. Tedeschi, and J.A. Frank Regionally specific neuronal pathology in untreated patients with schizophrenia: a proton magnetic resonance spectroscopic imaging study Biol. Psychiatry 43 1998 641 648
5. M.S. Buchsbaum, S.G. Potkin, B.V. Siegel Jr., J. Lohr, M. Katz, L.A. Gottschalk, B. Gulasekaram, J.F. Marshall, S. Lottenberg, and C.Y. Teng Striatal metabolic rate and clinical response to neuroleptics in schizophrenia Arch. Gen. Psychiatry 49 1992 966 974
6. 1H-magnetic resonance spectroscopy of the left frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates Biol. Psychiatry 36 1994 792 800
7. J.R. Bustillo, J. Lauriello, L.M. Rowland, L.M. Thomson, H. Petropoulos, R. Hammond, B. Hart, and W.M. Brooks Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposure Schizophr. Res. 58 2002 313 321
8. J.R. Bustillo, C. Wolff, A.M. Gutierrez, T.S. Dettmer, T.B. Cooper, A. Allan, J. Lauriello, and C.F. Valenzuela Treatment of rats with antipsychotic drugs: lack of an effect on brain N-acetyl aspartate levels Schizophr. Res. 66 2004 31 39
9. K.M. Cecil, R.E. Lenkinski, R.E. Gur, and R.C. Gur Proton magnetic resonance spectroscopy in the frontal and temporal lobes of neuroleptic naive patients with schizophrenia Neuropsychopharmacology 20 1999 131 140
10. M.H. Chakos, J.A. Lieberman, J. Alvir, R. Bilder, and M. Ashtari Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine Lancet 345 1995 456 457
11. G. Chakraborty, P. Mekala, D. Yahya, G. Wu, and R.W. Ledeen Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase J. Neurochem. 78 2001 736 745
12. B. Choe, K. Kim, T. Suh, C. Lee, I. Paik, Y. Bahk, K. Shinn, and R. Lenkinski H-magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-naïve, chronic schizophrenia Acad. Radiol. 1 1994 211 216
13. N. De Stefano, P.M. Matthews, and D.L. Arnold Reversible decrease in N-acetylaspartate after acute brain injury Magn. Reson. Med. 34 1995 721 727
14. R.F. Deicken, L. Zhou, N. Schuff, G. Fein, and M.W. Weiner Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy Biol. Psychiatry 43 1998 483 488
15. C. Demougeot, P. Garnier, C. Mossiat, N. Bertrand, M. Giroud, A. Beley, and C. Marie N-acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury J. Neurochem. 77 2001 408 415
16. S.L. Eastwood, P.W. Burnet, and P.J. Harrison Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain Synapse 36 2000 167 177
17. D. Fannon, A. Simmons, L. Tennakoon, S. O'Ceallaigh, A. Sumich, V. Doku, C. Shew, and T. Sharma Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia Biol. Psychiatry 54 2003 587 598
18. H. Fukuzako, K. Takeuchi, Y. Hokazono, T. Fukuzako, K. Yamada, and T. Hashiguchi Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report Psychiatry Res. Neuroimaging 61 1995 193 200
19. R.E. Gur, V. Maany, P.D. Mozley, C. Swanson, W. Bilker, and R.C. Gur Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia Am. J. Psychiatry 155 1998 1711 1717
20. P. Harrison The neuropathological effects of antipsychotic drugs Schizophr. Res. 40 1999 87 99
21. M.K. Harte, S.B. Powell, L.M. Reynolds, N.R. Swerdlow, M.A. Geyer, and G.P. Reynolds Reduced n-acetylaspartate in the temporal cortex of rats reared in isolation Biol. Psychiatry 56 2004 296 299
22. H.H. Holcomb, N.G. Cascella, G.K. Thaker, D.R. Medoff, R.F. Dannals, and C.A. Tamminga Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol Am. J. Psychiatry 153 1996 41 49
23. S. Kalra, S.H. Cashman, A. Genge, and D.L. Arnold Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy NeuroReport 9 1998 1757 1761
24. L.S. Kegeles, D.C. Shungu, S. Anjilvel, S. Chan, S.P. Ellis, and E. Xanthopoulos Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies Psychiatry Res. 98 2000 163 175
25. S. Kroesen, J. Marksteiner, S.K. Mahata, M. Mahata, R. Fischer-Colbrie, A. Saria, I. Kapeller, and H. Winkler Effects of haloperidol, clozapine and citalopram on messenger RNA levels of chromogranins A and B and secretogranin II in various regions of rat brain Neuroscience 69 1995 881 891
26. D.M. Lindquist, R.M. Hawk, C.N. Karson, and R.A. Komoroski Effects of antipsychotic drugs on metabolite ratios in rat brain in vivo Magn. Reson. Med. 43 2000 355 358
27. C.K. Meshul, and D.E. Casey Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment Brain Res. 489 1989 338 346
28. C.K. Meshul, A. Janowsky, D.E. Casey, R.K. Stallbaumer, and B. Taylor Coadministration of haloperidol and SCH-23390 prevents the increase in 'perforated' synapses due to either drug alone Neuropsychopharmacology 7 1992 285 293
29. J.R. Moffett, M.A. Namboodiri, C.B. Cangro, and J.H. Neale Immunohistochemical localisation of N-acetylaspartate in rat brain NeuroReport 2 1991 131 134
30. V. Molina, J. Sánchez, S. Reig, J. Sanz, C. Benito, C. Santamarta, J. Pascau, F. Sarramea, J.D. Gispert, and J.M. Misiego N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration Schizophr. Res. 73 2005
31. S. Nudmamud, L.M. Reynolds, and G.P. Reynolds N-acetylaspartate and N-acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder Biol. Psychiatry 53 2003 1138 1141
32. M. Omori, T. Murata, H. Kimura, Y. Koshimoto, H. Kado, Y. Ishimori, H. Ito, and Y. Wada Thalamic abnormalities in patients with schizophrenia revealed by proton magnetic resonance spectroscopy Psychiatry Res. 98 2000 155 162
33. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates fourth edition 1998 Academic Press Orlando, FL
34. O.A. Petroff, L.D. Errante, D.L. Rothman, J.H. Kim, and D.D. Spencer Neuronal and glial metabolite content of the epileptogenic human hippocampus Ann. Neurol. 52 2002 635 642
35. L.T. Rael, G.W. Thomas, R. Bar-Or, M.L. Craun, and D. Bar-Or An anti-inflammatory role for N-acetyl aspartate in stimulated human astroglial cells Biochem. Biophys. Res. Commun. 2 2004 847 853
36. P.F. Renshaw, D.A. Yurgelun-Todd, G.S. Tohen, and B.M. Cohen Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis Am. J. Psychiatry 152 1995 444 446
37. L.M. Reynolds, and G.P. Reynolds Post-mortem N-acetylaspartate in schizophrenia, bipolar disorder and depression J. Psychopharmacol. 18 2004 A66 (Supl.)
38. L.M. Reynolds, S.M. Cochran, B.J. Morris, J.A. Pratt, and G.P. Reynolds Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain Schizophr. Res. 73 2005
39. 1H-MRS) studies of schizophrenia Semin. Clin. Neuropsychiatry 6 2001 121 130
40. R.E. See, M.A. Chapman, and C.K. Meshul Comparison of chronic intermittent haloperidol and raclopride effects on striatal dopamine release and synaptic ultrastructure in rats Synapse 12 1992 147 154
41. L.D. Selemon, M.S. Lidow, and P.S. Goldman-Rakic Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure Biol. Psychiatry 46 1999 161 172
42. T. Sigmundsson, M. Maier, B.K. Toone, S.C. Williams, A. Simmons, K. Greenwood, and M.A. Ron Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study Schizophr. Res. 64 2003 63 71
43. H.H. Tallan, S. Moore, and W.H. Stein N-acetyl-l-aspartic acid in brain J. Biol. Chem. 219 1956 257 264
44. + J. Neurochem. 62 1994 2349 2355
45. N.A. Uranova, D.D. Orlovskaya, K. Apel, A.J. Klintzova, U. Haselhörst, and H. Schenk Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment Synapse 7 1991 253 259