Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy

Biological Psychiatry

Volumn 43, Issue 7, 1998, Pages 483-488

  Deicken, Raymond F ^a,c,d   Zhou, Ling ^c   Schuff, Norbert ^a,b   Fein, George ^a,c   Weiner, Michael W ^a,b,c  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Psychiatry Service   (United States)

Author keywords

Brain; Hippocampus; Limbic system; Magnetic resonance spectroscopy; N acetylaspartate; Schizophrenia

Indexed keywords

CHOLINE; CREATININE; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; BRAIN METABOLISM; BRAIN SCINTISCANNING; CLINICAL ARTICLE; FEMALE; HIPPOCAMPUS; HUMAN; LIMBIC SYSTEM; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; ASPARTIC ACID; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NEURONS; PILOT PROJECTS; SCHIZOPHRENIA;

EID: 0032053871     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(97)00490-3     Document Type: Article

References (32)

1. Annett M (1970): A classification of hand preference by association analysis. Br J Psychol 61:303-321.
2. Arnold SE, Hyman BT, Hoesen GWV, Damasio AR (1991): Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 48:625-632.
3. Arnold SE, Franz BR, Gur RC, et al (1995): Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am J Psychiatry 152:738-748.
4. Barker PB, Breiter SN, Soher BJ, et al (1994): Quantitative proton spectroscopy of canine brain: In vivo and in vitro correlations. Magn Reson Med 32:157-163.
5. Bertolino A, Callicott JH, Elman I, et al (1996a): Proton magnetic resonance spectroscopic imaging in drug free patients with schizophrenia: Regional neuronal damage [abstract]. Biol Psychiatry 39:634.
6. Bertolino A, Nawroz S, Mattay VS, et al (1996b): Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multi-slice proton magnetic resonance spectroscopic imaging. Am J Psychiatry 153:1554-1563.
7. Birken DL, Oldendorf WH (1989): N-acetyl-1-aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 13:23-31.
8. Bogerts B, Meertz E, Schonfeldt-Bausch R (1985): Basal ganglia and limbic system pathology in schizophrenia. Arch Gen Psychiatry 42:784-791.
9. Bogerts G, Falkai P, Haupts M, et al (1990): Post-mortem volume measurements of limbic system and basal ganglia structures in chronic schizophrenics: Initial results from a new brain collection. Schizophr Res 3:295-301.
10. 1H magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates. Biol Psychiatry 36:792-800.
11. Conrad AJ, Abebe T, Austin R, Forsythe S, Scheibel AB (1991): Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. Arch Gen Psychiatry 48:413-417.
12. Davie CA, Hawkins CP, Barker GJ, et al (1994): Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 117:49-58.
13. De Stefano N, Matthews PM, Arnold DL (1995): Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med 34:721-727.
14. Ende G, Knowlton R, Laxer KD, Matson GB, Weiner MW (1996): NAA is a more sensitive marker of hippocampal disease than atrophy: Evidence that NAA is a neuronal marker [abstract]. Proc Soc Magn Reson 3:144.
15. Falkai P, Bogerts B, Rozumek M (1988): Limbic pathology in schizophrenia: The entorhinal region - A morphometric study. Biol Psychiatry 24:515-521.
16. Frahm J, Michaelis T, Merboldt KD, Hanicke W, Gyngell ML, Bruhn H (1991): On the N-acetyl methyl resonance in localized 1H NMR spectra of human brain in vivo. NMR Biomed 4:201-204.
17. Fukuzako H, Takeuchi K, Hokazono Y, et al (1995): Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: Preliminary report. Psychiatry Res Neuroimaging 61:193-200.
18. 1H chemical shift imaging [abstract]. Proc Soc Magn Reson 3:1779.
19. Jeste DV, Lohr JB (1989): Hippocampal pathologic findings in schizophrenia: A morphometric study. Arch Gen Psychiatry 46:1019-1024.
20. Maier M, Ron MA, Barker GJ, Tofts PS (1995): Proton magnetic resonance spectroscopy: An in vivo method of estimating hippocampal neuronal depletion in schizophrenia. Psychol Med 25:1201-1209.
21. Maudsley AA, Lin E, Weiner MW (1992): Spectroscopic imaging display and analysis. Magn Reson Imaging 10:471-485.
22. Maudsley AA, Matson GB, Hugg JW. Weiner MW (1994): Reduced phase encoding in spectroscopic imaging. Magn Reson Med 31:645-651.
23. 1H MRS) of the hippocampal formation in schizophrenia: A pilot study. Br J Psychiatry 165:481-485.
24. Okumura N, Otsuki S, Nasu H (1959): The influence of insulin hypoglycemic coma, repeated electroshocks, and chlorpromazine or beta-phenylisopropylmethylamine administration on the free amino acids in the brain. J Biochem (Tokyo) 46:247-252.
25. 1H magnetic resonance spectroscopy study. Magn Reson Med 33:595-600.
26. Renshaw P, Yurgelun-Todd D, Tohen M, Gruber S, Cohen B (1995): Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis. Am J Psychiatry 152:444-446.
27. Ross B, Michaelis T (1994): Clinical applications of magnetic resonance spectroscopy. Magn Reson Q 10:191-247.
28. Tedeschi G, Bertolino A, Righini A, et al (1995): Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. Neurology 45:1384-1391.
29. Tsai G, Passani LA, Slusher BS, et al (1995): Abnormal excitatory neurotransmitter metabolism in schizophrenic-brains. Arch Gen Psychiatry 52:829-836.
30. Urenjak J, Williams SR, Gadian DG, Noble M (1993): Proton magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 13:981-989.
31. Williamson P, Pelz D, Merskey H, et al (1992): Frontal, temporal, and striatal proton relaxation times in schizophrenic patients and normal comparison subjects. Am J Psychiatry 149:549-551.
32. Yurgelun-Todd DA, Renshaw PF, Gruber SA, et al (1996): Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and normal controls. Schizophr Res 19:55-59.