Adipokine dysregulation in Turner syndrome: Comparison of circulating interleukin-6 and leptin concentrations with measures of adiposity and C-reactive protein

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 5, 2005, Pages 2948-2953

  Ostberg, Julia E ^a   Attar, M Javad Hosseinzadeh ^b   Mohamed Ali, Vidya ^b   Conway, Gerard S ^a,c  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c MIDDLESEX HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; ESTROGEN; INSULIN; INTERLEUKIN 6; LEPTIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIABETES MELLITUS; ESTROGEN THERAPY; FEMALE; HUMAN; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KARYOTYPE 46,XX; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; OBESITY; PREMATURE OVARIAN FAILURE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; TURNER SYNDROME; UNITED KINGDOM;

ADIPOSE TISSUE; ADULT; C-REACTIVE PROTEIN; FEMALE; HUMANS; INTERLEUKIN-6; LEPTIN; OBESITY; OVARIAN FAILURE, PREMATURE; TURNER SYNDROME;

EID: 18844375808     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1966     Document Type: Article

References (46)

1. Gravholt CH, Juul S, Naeraa RW, Hansen J 1998 Morbidity in Turner syndrome. J Clin Epidemiol 51:147-158
2. Swerdlow AJ, Hermon C, Jacobs PA, Alberman E, Beral V, Daker M, Fordyce A, Youings S 2001 Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study. Ann Hum Genet 65:177-188
3. Naeraa RW, Gravholt CH, Hansen J, Nielsen J, Juul S 1995 Mortality in Turner syndrome. In: Albertsson-Wikland K, Ranke M, eds. Turner syndrome in a life-span perspective: research and clinical aspects. Amsterdam: Elsevier Science; Excerpta Medica; Int Congr Ser 1089:323
4. Elsheikh M, Conway GS 1998 The impact of obesity on cardiovascular risk factors in Turner's syndrome. CUn Endocrinol (Oxf) 49:447-450
5. Gravholt CH, Naeraa RW, Nyholm B, Gerdes LU, Christiansen E, Schmilz O, Christiansen JS 1998 Glucose metabolism, lipid metabolism, and cardiovascular risk factors in adult Turner's syndrome. The impact of sex hormone replacement. Diabetes Care 21:1062-1070
6. Ross JL, Feuillan F, Long LM, Kowal K, Kushner H, Cutler Jr GB 1995 Lipid abnormalities in Turner syndrome. J Pediatr 126:242-245
7. 1988 UK Prospective Diabetes Study IV. Characteristics of newly presenting type 2 diabetic patients: male preponderance and obesity at different ages. Multi-center study. Diabet Med 5:154-159
8. Morris RD, Rimm DL, Hartz AJ, Kalkhoff RK, Rimm AA 1989 Obesity and heredity in the etiology of non-insulin-dependent diabetes mellitus in 32,662 adult white women. Am J Epidemiol 130:112-121
9. Reaven GM 2002 Multiple CHD risk factors in type 2 diabetes: beyond hyperglycaemia. Diabetes Obes Metab 4(Suppl 1):S13-S18
10. Einhorn D, Reaven GM, Cobin RH, Ford E, Ganda OF, Handelsman Y, Hellman R, Jellinger FS, Kendall D, Krauss RM, Neufeld ND, Fetak SM, Rodbard HW, Seibel JA, Smith DA, Wilson FW 2003 American College of Endocrinology position statement on the insulin resistance syndrome. Endocr Pract 9:237-252
11. Yudkin JS, Juhan-Vague I, Hawe E, Humphries SE, di Minno G, Margaglione M, Tremoli E, Kooistra T, Morange PE, Lundman P, Mohamed-Ali V, Hamsten A 2004 Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study. Metabolism 53:852-857
12. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW 1997 Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab 82:4196-4200
13. Pinkney JH, Coppack SW, Mohamed-Ali V 1998 Effect of isoprenaline on plasma leptin and lipolysis in humans. Clin Endocrinol (Oxf) 48:407-411
14. Silventoinen K, Jousilahti P, Vartiainen E, Tuomilehto J 2003 Appropriateness of anthropometric obesity indicators in assessment of coronary heart disease risk among Finnish men and women. Scand J Public Health 31:283-290
15. Dalton M, Cameron AJ, Zimmet PZ, Shaw JE, Jolley D, Dunstan DW, Welbom TA 2003 Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults. J Intern Med 254:555-563
16. Megnien JL, Denarie N, Cocaul M, Simon A, Levenson J 1999 Predictive value of waist-to-hip ratio on cardiovascular risk events. Int J Obes Relat Metab Disord 23:90-97
17. Zhu S, Heshka S, Wang Z, Shen W, Allison DB, Ross R, Heymsfield SB 2004 Combination of BMI and waist circumference for identifying cardiovascular risk factors in whites. Obes Res 12:633-645
18. Walsh BW, Schiff I, Rosner B, Greenberg L, Ravnikar V, Sacks FM 1991 Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 325:1196-1204
19. Godsland IF, Manassiev NA, Felton CV, Proudler AJ, Crook D, Whitehead MI, Stevenson JC 2004 Effects of low and high dose oestradiol and dydrogesterone therapy on insulin and lipoprotein metabolism in healthy postmenopausal women. Clin Endocrinol (Oxf) 60:541-549
20. Godsland IF 1996 The influence of female sex steroids on glucose metabolism and insulin action. J Intern Med 738(Suppl):1-60
21. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, Cauley JA, Barrett-Connor E 2003 Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 138:1-9
22. Bakalov VK, Cooley MM, Quon MJ, Luo ML, Yanovski JA, Nelson LM, Sullivan G, Bondy C 2004 Impaired insulin secretion in the Turner metabolic syndrome. J Clin Endocrinol Metab 89:3516-3520
23. Caprio S, Boulware S, Diamond M, Sherwin RS, Carpenter TO, Rubin K, Amiel S, Press M, Tamborlane WV 1991 Insulin resistance: an early metabolic defect of Turner's syndrome. J Clin Endocrinol Metab 72:832-836
24. Nielsen J, Johansen K, Yde H 1969 The frequency of diabetes mellitus in patients with Turner's syndrome and pure gonadal dysgenesis. Blood glucose, plasma insulin and growth hormone level during an oral glucose tolerance test. Acta Endocrinol (Copenh) 62:251-269
25. Weyer C, Bogardus C, Mott DM, Pratley RE 1999 The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794
26. Van Harmelen V, Reynisdottir S, Eriksson P, Thome A, Hoffstedt J, Lonnqvist F, Amer P 1998 Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 47:913-917
27. Coppack SW 2001 Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc 60:349-356
28. Flower L, Gray R, Pinkney J, Mohamed-Ali V 2003 Stimulation of interleukin-6 release by interleukin-1β from isolated human adipocytes. Cytokine 21:32-37
29. Lear SA, Chen MM, Birmingham CL, Frohlich JJ 2003 The relationship between simple anthropometric indices and C-reactive protein: ethnic and gender differences. Metabolism 52:1542-1546
30. Ridker PM, Hennekens CH, Buring JE, Rifai N 2000 C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836-843
31. Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A, Sattar N 2001 Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 104:3052-3056
32. Lemieux I, Pascot A, Prud'homme D, Aimeras N, Bogaty P, Nadeau A, Bergeron J, Despres JP 2001 Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vase Biol 21:961-967
33. Forouhi NG, Sattar N, McKeigue PM 2001 Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians. Int J Obes Relat Metab Disord 25:1327-1331
34. Wajchenberg BL, Giannella-Neto D, da Silva ME, Santos RF 2002 Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome. Horm Metab Res 34:616-621
35. Silvestri A, Gebara O, Vitale C, Wajngarten M, Leonardo F, Ramires JA, Fini M, Mercuro G, Rosano GM 2003 Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response. Circulation 107:3165-3169
36. Fradhan AD, Manson JE, Rossouw JE, Siscovick DS, Mouton CF, Rifai N, Wallace RB, Jackson RD, Fettinger MB, Ridker FM 2002 Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study. JAMA 288:980-987
37. Brooks-Asplund EM, Tupper CE, Daun JM, Kenney WL, Cannon JG 2002 Hormonal modulation of interleukin-6, tumor necrosis factor and associated receptor secretion in postmenopausal women. Cytokine 19:193-200
38. Zegura B, Keber I, Sebestjen M, Koenig W 2003 Double blind, randomized study of estradiol replacement therapy on markers of inflammation, coagulation and fibrinolysis. Atherosclerosis 168:123-129
39. Miller AF, Chen YF, Xing D, Feng W, Oparil S 2003 Hormone replacement therapy and inflammation: interactions in cardiovascular disease. Hypertension 42:657-663
40. Tai ES, Lau TN, Ho SC, Fok AC, Tan CE 2000 Body fat distribution and cardiovascular risk in normal weight women. Associations with insulin resistance, lipids and plasma leptin. Int J Obes Relat Metab Disord 24:751-757
41. Hojbjerg Gravholt C, Weis Naeraa R 1997 Reference values for body proportions and body composition in adult women with Ullrich-Turner syndrome. Am J Med Genet 72:403-408
42. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsk J, Caro JF 1996 Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes 45:699-701
43. de Courten M, Zimmet F, Hodge A, Collins V, Nicolson M, Staten M, Dowse G, Alberti KG 1997 Hyperleptinaemia: the missing link in the metabolic syndrome? Diabet Med 14:200-208
44. Leyva F, Godsland IF, Ghatei M, Proudler AJ, Aldis S, Walton C, Bloom S, Stevenson JC 1998 Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk. Arterioscler Thromb Vase Biol 18:928-933
45. Weigle DS, Bukowski TR, Foster DC, Holderman S, Krämer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL 1995 Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96:2065-2070
46. Heini AF, Lara-Castro C, Kirk KA, Considine RV, Caro JF, Weinsier RL 1998 Association of leptin and hunger-satiety ratings in obese women. Int J Obes Relat Metab Disord 22:1084-1087