Bile-pancreatic juice exclusion increases p38MAPK activation and TNF-α production in ligation-induced acute pancreatitis in rats

Pancreatology

Volumn 5, Issue 1, 2005, Pages 20-26

  Samuel, Isaac ^a   Zaheer, Smita ^a   Zaheer, Asgar ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Acinar cell; Acute pancreatitis; Cholecystokinin; Cytokine; Donor rat model; MAP kinase; p38; Pancreas; Signal transduction; Stress activated protein kinase; TNF

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HOMOGENATE; HYPOTHESIS; IMMUNOBLOTTING; MALE; NONHUMAN; PANCREAS; PANCREAS DUCT; PANCREAS DUCT LIGATION; PANCREAS JUICE; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

EID: 18744413948     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000084486     Document Type: Article

References (22)

1. Saluja AK, Steer MLP: Pathophysiology of pancreatitis. Role of cytokines and other mediators of inflammation. Digestion 1999; 60(suppl 1):27-33.
2. MAPK induction of tumor necrosis factor-α in pancreatitis-associated pulmonary injury. Surgery 1999;126:216-222.
3. Norman J: The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998;175:76-83.
4. Karne S, Gorelick F: Etiopathogenesis of acute pancreatitis. Surg Clin North Am 1999;79:699-710.
5. MAPK and NF-κB activation in acute pancreatitis. Pancreatology 2004;4:49-56.
6. Samuel I, Zaheer S, Fisher RA, Zaheer A: Cholinergic receptor induction and JNK activation in acute pancreatitis. Am J Surg 2003;186:569-574.
7. Samuel I, Toriumi Y, Wilcockson DP, Turkelson CM, Solomon TE, Joehl RJ: Bile and pancreatic juice replacement ameliorates early ligation-induced acute pancreatitis in rats. Am J Surg 1995;169:391-399.
8. Kaplan R, Zaheer A, Jaye M, Lim R: Molecular cloning and expression of biologically active human glia maturation factor-β. J Neurochem 1991;57:483-490.
9. Zaheer A, Lim R: In vitro inhibition of MAP kinase (ERK1/ERK2) activity by phosphorylated glia maturation factor. Biochemistry 1996;35:6283-6288.
10. Samuel I, Joehl RJ: Bile-pancreatic juice replacement, not cholinergic and cholecystokinin-receptor blockade, reverses acinar cell hyperstimulation after bile-pancreatic duct ligation. Am J Surg 1996;171:207-211.
11. Cameron JL, Mehigan D, Zuidema GD: Evaluation of atropine in acute pancreatitis. Surg Gynecol Obstet 1979;148:206-208.
12. Denham W, Yang J, Norman J: Evidence for an unknown component of pancreatic ascites that induces adult respiratory distress syndrome through an interleukin-1 and tumor necrosis factor-dependent mechanism. Surgery 1997;122:295-301.
13. Steer ML: Pathobiology of experimental acute pancreatitis. Yale J Biol Med 1992;65:421-430.
14. Fink G, Yang J, Carter G, Ward K, Ulrich P, Tracey K, Norman J: A low molecular weight macrophage inhibitor decreases severity of pancreatitis through inhibition of IL-1 nad TNF production. Surg Forum 1996;47:137-140.
15. Kyriakis JM, Avruch J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001;81:807-869.
16. Schafer C, Williams JA: Stress kinases and heat-shock proteins in the pancreas: Possible roles in normal function and disease. J Gastroenterol 2000;35:1-9.
17. Fleischer F, Dabew R, Goke B, Wagner AC: Stress kinase inhibition modulates acute experimental pancreatitis. World J Gastroenterol 2001;7:259-265.
18. Yang J, Denham W, Tracey KJ, Wang H, Kramer AA, Salhab KF, Norman J: The physiologic consequences of macrophage pacification during severe acute pancreatitis. Shock 1998;10:169-175.
19. Yang J, Denham W, Carter G, Tracey KJ, Norman J: Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor-α and interleukin-1β. Hepatology 1998;28:1282-1288.
20. MAPK, ERK1/2, SAPK/JNK, and NF-κB. J Gastrointest Surg 2003;7:20-25.
21. Murr MM, Yang J, Fier A, Kaylor P, Mastorides S, Norman JG: Pancreatic elastase induces liver injury by activating cytokine production within Kupffer cells via nuclear factor-κB. J Gastrointest Surg 2002;6:474-480.
22. Hommes D, Van den Blink B, Plasse T, Bartelsman J, Xu CP, MacPherson B, Tytgat G, Peppelenbosch M, Van Deventer S: Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 2002;122:7-14.