β cell neogenesis from ducts and phenotypic conversion of residual islet cells in the adult pancreas of glucose intolerant mice induced by selective alloxan perfusion

Endocrine Journal

Volumn 49, Issue 5, 2002, Pages 561-572

  Li, Ming ^a   Miyagawa, Jun ichiro ^a   Yamamoto, Koji ^a   Moriwaki, Makoto ^a   Imagawa, Akihisa ^a   Iwahashi, Hiromi ^a   Yamagata, Kazuya ^a   Tochino, Yoshihiro ^a   Hanafusa, Toshiaki ^a   Matsuzawa, Yuji ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Differentiation; Duct cell; Isl1; Nkx2.2; Pax6

Indexed keywords

ALLOXAN; GLUCAGON; INSULIN; PANCREAS HORMONE; SOMATOSTATIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ISL1; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; GLUCOSE INTOLERANCE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; ANIMAL; CELL DIVISION; CHEMICALLY INDUCED DISORDER; CHEMISTRY; ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; INSTITUTE FOR CANCER RESEARCH MOUSE; PANCREAS DUCT; PANCREAS ISLET; PATHOLOGY;

ALLOXAN; ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; GLUCAGON; GLUCOSE INTOLERANCE; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED ICR; MICROSCOPY, ELECTRON; PANCREATIC DUCTS; PHENOTYPE; SOMATOSTATIN; TRANS-ACTIVATORS;

EID: 18744409043     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.49.561     Document Type: Article

References (26)

1. Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor-1 is required for pancreas development in mice. Nature 371: 606-609.
2. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV (1996) PDX-1 is required for pancreatic outgrowth and differentiation of rostral duodenum. Development 122: 983-995.
3. Walther C, Gruss P (1991) A murine paired box gene, is expressed in the developing CNS. Development 113: 1435-1449.
4. Ahlgren Ulf, Pfaff SL, Jessell TM, Edlund T, Edlund H (1997) Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385: 257-260.
5. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS (1998) Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic βcells. Development 125: 2213-2221.
6. Githens S (1988) The pancreatic duct cell: Proliferative capabilities, specific characteristics, metaplasia, isolation and culture. J Ped Gastroent Nutr 7: 486-506.
7. Dutrillaux MC, Portha B, Roze C, Hollande E (1982) Ultrastructural study of pancreatic cell regeneration in newborn rats after destruction by streptozotocin. Virchows Arch (Cell Pathol) 39: 173-185.
8. Rosenberg L, Vinik AI (1989) Induction of endocrine cell differentiation: New approach to management of diabetes. J Lab Clin Med 114: 75-83.
9. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. Diabetes 42: 1715-1720.
10. Waguri M, Yamamoto K, Miyagawa J, Tochino Y, Yamamori K, Kajimoto Y, Nakajima H, Watada H, Yoshiuchi I, Itoh N, Imagawa A, Namba M, Kuwajima M, Yamasaki Y, Hanafusa T, Matsuzawa Y (1997) Demonstration of two different processes of β-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes 46: 1281-1290.
11. Yamamoto K, Miyagawa J, Waguri M, Itoh N, Imagawa A, Kuwajima M, Nakajima H, Namba M, Tochino Y, Hanafusa T, Matsuzawa Y (1997) Proliferation and differentiation of pancreatic β-cells: Ultrastructural analysis of the pancreas in diabetic mice induced by selective alloxan perfusion. Med Electron Microsc 30: 170-175.
12. Wang RN, Bouwens L, Klöppel G (1994) Beta-cell proliferation in normal and streptozocin-treated newborn rats: Site, dynamics and capacity. Diabetologia 37: 1088-1096.
13. Slack MW (1995) Developmental biology of the pancreas. Development 121: 1569-1580.
14. Bouwens L, Lu WG, De Krijger R (1997) Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia 40: 398-404.
15. Sander M, German MS (1997) The β cell transcription factors and development of the pancreas. J Mol Med 75: 327-340.
16. Yamamoto K, Miyagawa J, Itoh N, Nakajima H, Waguri M, Shimada T, Yasuda K, Kono N, Kuwajima M, Hanafusa T, Matsuzawa Y (1997) Differentiation of β-cells from ductal cells and acceleration of this process by nicotinamide: Ultrastructural study on the non-obese diabetic (NOD) mice with overt diabetes. Biomed Res 18: 171-178.
17. Bouwens L, Klöppel G (1996) Islet cell neogenesis in the pancreas. Virchows Arch 427: 553-560.
18. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir S (1999) The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48: 507-513.
19. Teitelman G (1991) Cellular and molecular analysis of pancreatic islet cell lineage and differentiation. Recent Prog Horm Res 47: 259-294.
20. Teitelman G, Alpert S, Polak JM, Martinez A, Hanahan D (1993) Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118: 1031-1039.
21. Gu DL, Sarvetnick N (1993) Epithelial cell proliferation and islet neogenesis in IFN-γ transgenic mice. Development 118: 33-46.
22. Rafaeloff R, Pittenger GL, Barlow SW, Qin XF, Yan B, Rosenberg L, Duguid WP, Vinik AI (1997) Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest 99: 2100-2109.
23. Fernandes A, Kingand LC, Guz Y, Stein R, Wright CVE, Teitelman G (1997) Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138: 1750-1762.
24. Watada H, Kajimoto Y, Miyagawa J, Hanafusa T, Hamaguti K, Matsuoka T, Yamamoto K, Matsuzawa Y, Kawamori R, Yamasaki Y (1996) PDX-1 induces insulin and glucokinase gene expression in αTC1 clone 6 cells in the presence of betacellulin. Diabetes 45: 1826-1831.
25. Leonard J, Peers B, Johnson T, Ferreri K, Lee S and Montminy MR (1993) Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 7: 1275-1283.
26. Zulewski H, Abraham EJ, Gerlach MJ, Daniel PB, Moritz W, Muller B, Vallejo M, Thomas MK, Habener JF (2001) Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50: 521-533.