Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor

European Journal of Pharmacology

Volumn 396, Issue 1, 2000, Pages 1-8

  Wood, Martyn ^a   Chaubey, Mark ^a   Atkinson, Peter ^a   Thomas, David R ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT (5 Hydroxytryptamine serotonin); 5 HT receptor; 8 OH DPAT (8 hydroxy N, N dipropylaminotetralin); FLIPR (flourescent imaging plate reader); Fluorescence; Meta chlorophenylpiperazine

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CARBAMOYLTRYPTAMINE; ADENYLATE CYCLASE; GUANINE NUCLEOTIDE BINDING PROTEIN; N ETHYLMALEIMIDE; RECEPTOR SUBTYPE; SEROTONIN 7 RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR; THAPSIGARGIN; TRYPTAMINE;

ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CELL CULTURE; CONTROLLED STUDY; FLUORESCENCE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; RECEPTOR BINDING; SEROTONINERGIC SYSTEM; TECHNIQUE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADENYLATE CYCLASE; ANILINE COMPOUNDS; CALCIUM; CALCIUM SIGNALING; CELL LINE; FLUORESCENT DYES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; KIDNEY; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; XANTHENES;

EID: 0034640191     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00213-2     Document Type: Article

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