Vascular contractile response and signal transduction in endothelium-denuded aorta from cirrhotic rats

World Journal of Gastroenterology

Volumn 11, Issue 15, 2005, Pages 2306-2312

  Lin, Han Chieh ^a   Yang, Ying Ying ^b   Huang, Yi Tsau ^b   Lee, Tzung Yan ^b   Hou, Ming Chih ^a   Lee, Fa Yauh ^a   Lee, Shou Dong ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Cirrhosis; Inositol trisphosphate; Portal hypertension; Protein kinase C; Vascular reactivity

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ALUMINUM CHLORIDE; ARGIPRESSIN; FLUORIDE SODIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INOSITOL TRISPHOSPHATE; N6 (1 IMINOETHYL)LYSINE; NITRIC OXIDE; PHENYLEPHRINE; PHORBOL ESTER DERIVATIVE; PHOSPHOLIPASE C; PROTEIN KINASE C; INOSITOL 1,4,5 TRISPHOSPHATE; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; EX VIVO STUDY; HEMODYNAMICS; LIVER CIRRHOSIS; MALE; MUSCLE CONTRACTILITY; NONHUMAN; PORTAL HYPERTENSION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; THORACIC AORTA; VASCULAR RING; ANIMAL; CYTOLOGY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

ANIMALS; AORTA, THORACIC; ENDOTHELIUM, VASCULAR; HYPERTENSION, PORTAL; INOSITOL 1,4,5-TRISPHOSPHATE; LIVER CIRRHOSIS; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 18744368147     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i15.2306     Document Type: Article

References (50)

1. Albillos A, Colombato LA, Groszmann RJ. Vasodilatation and sodium retention in prehepatic portal hypertension. Gastroenterology 1992; 102: 931-935
2. Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodés J. Peripheral arterial vasodilatation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988; 8: 1151-1157
3. Vorobioff J, Bredfeldt JE, Groszmann RJ. Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am J Physiol 1983; 244: G52-G57
4. Vorobioff J, Bredfeldt JE, Groszmann RJ. Increased blood flow through portal system in cirrhotic rats. Gastroenterology 1984; 87: 1120-1126
5. Benoit JN, Barrowman JA, Harper SL, Kvietys PR, Granger DN. Role of humoral factors in the intestinal hyperemia associated with chronic portal hypertension. Am J Physiol 1984; 247(5 Pt 1): G486-G493
6. Tahan V, Avsar E, Karaca C, Uslu E, Eren F, Aydin S, Uzun H, Hamzaoglu HO, Besisik F, Kalayci C, Okten A, Tozun N. Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension. World J Gastroenterol 2003; 9: 2325-2327
7. Pizcueta MP, Piqué JM, Fernández M, Bosch J, Rodés J, Whittle BJ, Moncada S. Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition. Gastroenterology 1992; 103: 1909-1915
8. Silva G, Navasa M, Bosch J, Chesta J, Pizcueta MP, Casamitjana R, Rivera F, Rodés J. Hemodynamic effect of glucagon in portal hypertension. Hepatology 1990; 11: 668-673
9. Sitzmann JV, Li SS, Lin PW. Prostacyclin mediates splanchnic vascular response to norepinephrine in portal hypertension. J Surg Res 1989; 47: 208-211
10. Sogni P, Moreau R, Gadano A, Lebrec D. The role of nitric oxide in the hyperdynamic circulating syndrome associated with portal hypertension. J Hepatol 1995; 23: 218-224
11. Oberti F, Sogni P, Cailmail S, Moreau R, Pipy B, Lebrec D. Role of prostacyclin in hemodynamic alteration in conscious rats with extrahepatic and intrahepatic portal hypertension. Hepatology 1993; 18: 621-627
12. Braillon A, Cailmail S, Gaudin C, Lebrec D. Reduced splanchnic vasoconstriction to angiotensin II in conscious rats with biliary cirrhosis. J Hepatol 1993; 17: 86-90
13. Karatapanis S, McCormick PA, Kakad S, Chin JKT, Islam M, Jeremy J, Harry D, McIntyre N, Burroughs AK, Jacob M. Alteration in vascular reactivity on isolated aortic rings from portal vein-constricted rats. Hepatology 1994; 20: 1516-1521
14. Kiel JW, Pitts V, Benoit JN, Granger DN, Shepherd AP. Reduced vascular sensitivity to norepinephrine in portal-hypertensive rats. Am J Physiol 1985; 248(2 Pt 1): G192-G195
15. 1-adrenoceptors of portal hypertensive rats. Br J Pharmacol 1994; 111: 439-444
16. MacGilchrist AJ, Sumner D, Ried JL. Impaired pressor reactivity in cirrhosis: evidence for a peripheral vascular defect. Hepatology 1991; 13: 689-694
17. Murray BM, Paller MS. Decreased pressor reactivity to angiotensin II in cirrhotic rats: Evidence for a post-receptor defect in angiotensin action. Circ Res 1985; 57: 424-431
18. Murray BM, Paller MS. Pressor resistance to vasopressin in sodium depletion, potassium depletion, and cirrhosis. Am J Physiol 1986; 251(3 Pt 2): R525-R530
19. Hadoke PWF, Hayes PC. In vitro evidence for vascular hyporesponsiveness in clinical and experimental cirrhosis. Pharmacol Ther 1997; 75: 51-68
20. Huang YT, Lin HC, Yu PC, Lee FY, Tsai YT, Lee SD, Yang MC. Decreased vascular reactivity of portal vein in rats with portal hypertension. J Hepatol 1996; 24: 194-199
21. Huang YT, Wang GF, Yang MC, Chang SP, Lin HC, Hong CY. Vascular hyporesponsiveness in aorta from portal hypertensive rats: possible sites of involvement. J Pharmacol Exp Ther 1996; 278: 535-541
22. Schepke M, Heller J, Paschke S, Thomas J, Wolff M, Neef M, Malago M, Molderings G, Spenngler U, Sauerbruch T. Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: evidence for a receptor-specific mechanism. Hepatology 2001; 34: 884-888
23. Van Obbergh L, Leonard V, Chen H, Xu D, Blaise G. The endothelial and non-endothelial mechanism responsible for attenuated vasoconstriction in cirrhotic rats. Exp Physiol 1995; 80: 609-617
24. Islam MZ, Williams BC, Madhavan KK, Hayes PC, Hadoke PWF. Selective alteration of agonist-mediated contraction in hepatic arteries isolated from patients with cirrhosis. Gastroenterology 2000; 118: 765-771
25. Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol 1984; 65: 305-311
26. Lee FY, Albillos A, Colombato LA, Groszmann RJ. The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats. Hepatology 1992; 16: 1043-1048
27. Lin HC, Yang MC, Hou MC, Li SM, Huang YT, Yu PC, Tsai YT, Lee SD. Effects of long-term administration of octreotide in portal vein-stenosed rats. Hepatology 1996; 23: 537-543
28. Bredt DS, Mourey RJ, Snyder SH. A simple, sensitive, and specific radioreceptor assay for inositol 1,4,5-trisphosphate in biological tissues. Biochem Biophys Res Common 1989; 159: 976-982
29. Huang YT, Yu PC, Lee FM, Lin HC, Hong CY, Yang MC. Decreased vascular contractile and inositol phosphate responses in portal hypertensive rats. Can J Physiol Pharmacol 1995; 73: 378-382
30. Challiss RA, Batty IH, Nahorski SR. Mass measurements of inositol (1,4,5) trisphosphate in rat cerebral cortex slices using a radioreceptor assay: effects of neurotransmitters and depolarization. Biochem Biophys Res Common 1988; 157: 684-691
31. Hathaway DR, March KL, Lash JA, Adam LP, Wilensky RL. Vascular smooth muscle: A review of the molecular basis of contractility. Circulation 1991: 83: 382-390
32. Somlyo AP, Somylo AV. Signal transduction and regulation in smooth muscle. Nature 1994; 372: 231-236
33. Sieber CC, Groszmann RJ. Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology 1992; 103: 235-239
34. Vallance P, Moncada S. Hyperdynamic circulation in cirrhosis: a role for nitric oxide? Lancet 1991; 1: 776
35. Fernández M, García-Pagán JC, Casadevall M, Bernadich C, Piera C, Whittle BJR, Piqué JM, Bosch J, Rodés J. Evidence against a role for inducible nitric oxide synthase in the hyperdynamic circulation of portal-hypertensive rats. Gastroenterology 1995; 108: 1487-1495
36. Niederberger M, Ginès P, Martin P, Tsai P, Morris K, McMurtry I, Schrier RW. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. Hepatology 1996; 24: 947-951
37. Wiest R, Groszmann RJ. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology 2002; 35: 478-491
38. Theodorakis NG, Wang YN, Skill NJ, Metz MA, Cahill PA, Redmond EH, Sitzmann JV. The role of nitric oxide synthase isoforms in extrahepatic portal hypertension, studies in gene-knockout mice. Gastroenterology 2003; 124: 1500-1508
39. Michielsen PP, Boeckxstaens GE, Sys SU, Herman AG, Pelckmans PA. The role of increased nitric oxide in the vascular hyporeactivity to noradrenalin in long-term portal vein ligated rats. J Hepatol 1995; 23: 341-347
40. Heller J, Schepke M, Gehnen N, Molderings GJ, Müller A, Erhard J, Spengler U, Sauerbruch T. Altered adrenergic responsiveness of endothelium-denuded hepatic arteries and portal veins in patients with cirrhosis. Gastroenterology 1999; 116: 387-393
41. 2-adrenoreceptors in patients with cirrhosis. Br J Clin Pharmacol 1990; 30: 644-647
42. Wu ZY, Benoit JN. Nonreceptor-mediated intestinal vasoconstriction in portal hypertensive rats. Am J Physiol 1994; 267(1 Pt 1): H370-H375
43. Heagerty AM, Ollerenshaw JD. The phosphoinositide signaling system and the pathogenesis of hypertension. In Hypertension: Pathophysiology, diagnosis, and management. Edited by Laragh JH and Brenner BM. Raven Press New York 1999: 1601-1615
44. Rasmussen H, Takuwa Y, Park S. Protein kinase C in the regulation of smooth muscle contraction. FASEB 1987; 1: 177-185
45. Hartleb M, Moreau R, Gaudin C, Lebrec D. Lack of vascular hyporesponsiveness to the L-type calcium channel activator, Bay K8644, in rats with cirrhosis. J Hepatol 1995; 22: 202-207
46. Castro A, Ros J, Jiménez W, Clària J, Llibre J, Leivas A, Arroyo V, Rivera F, Rodés J. Intracellular calcium concentration in vascular smooth muscle cells of rats with cirrhosis. J Hepatol 1994; 21: 521-526
47. Atucha NM, Ortiz MC, Martinez C, Quesada T, Garcia-Estan J. Role of protein kinase C in mesenteric pressor response of rats with portal hypertension. Br J Pharmacol 1996; 118: 277-282
48. Tazi KA, Moreau R, Heller J, Poirel O, Lebrec D. Changes in protein kinase C isoforms in association with vascular hyporeactivity in cirrhotic rat aortas. Gastroenterology 2000; 119: 201-210
49. Trombino C, Tazi KA, Gadano A, Moreau R, Lebrec D. Protein kinase C alteration in aortic vascular smooth muscle cells from rats with cirrhosis. J Hepatol 1998; 28: 670-676
50. Chagneau C, Tazi KA, Heller J, Sogni P, Poirel O, Moreau R, Lebrec D. The role of nitric oxide in the reduction of protein kinase C-induced contraction response in aorta from rats with portal hypertension. J Hepatol 2000; 33: 26-32