Role of protein kinase C in mesenteric pressor responses of rats with portal hypertension

British Journal of Pharmacology

Volumn 118, Issue 2, 1996, Pages 277-282

  Atucha, Noemí M ^a   Ortíz, M Clara ^a   Martínez, Concepción ^a   Quesada, Tomás ^a   García Estañ, Joaquín ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

Calphostin C; Mesenteric vascular bed; Methoxamine; Nitric oxide; Phorbol esters; Portal hypertension; Protein kinase C

Indexed keywords

CALPHOSTIN C; INDOMETACIN; METHOXAMINE; N(G) NITROARGININE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; MALE; MESENTERY; MESENTERY BLOOD FLOW; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VEIN LIGATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ENZYME ACTIVATION; HYPERTENSION, PORTAL; MALE; METHOXAMINE; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; SPLANCHNIC CIRCULATION;

EID: 0029944394     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15399.x     Document Type: Article

References (44)

1. AHLNER, J., AXELSSON, K.L., KARLSSON, J.G & ANDERSSON, R.G.G. (1988). Glyceril trinitrate inhibits phosphatidylinositol hydrolysis and protein kinase C activity in bovine mesenteric artery. Life Sci., 43, 1241-1248.
2. ATUCHA, N.M., GARCIA-ESTAÑ, J., RAMIREZ, A., PEREZ, M.C., QUESADA, T. & ROMERO, J.C. (1994). Renal effects of nitric oxide synthesis inhibition in cirrhotic rats. Am. J. Physiol., 267, R1454-R1460.
3. BLAUSTEIN, M.P. & SHIMA, H. (1992). Contrasting effects of phorbol-esters on serotonin- and vasopressin-evoked contractions in rat aorta and small mesenteric artery. Circ. Res., 70, 978-990.
4. BRUNS, R.F., MILLER, F.D., MERRIMAN, R.L., HOWBERT, J.J., HEATH, W.F., KOBAYASHI, E., TAKAHASHI, I., TAMAOKI, T. & NAKANO, H. (1991). Inhibition of protein kinase C by calphostin C is light-dependent. Biochem. Biophys. Res. Commun., 176, 288-293.
5. CAHILL, P.A., WU, Y. & SITZMANN, J.V. (1994). Altered adenylyl cyclase activities and G-protein abnormalities in portal hypertensive rabbits. J. Clin. Invest., 93, 2691-2700.
6. CARRIER, G.O. & WHITE, R.E. (1985). Enhancement of alpha-1 and alpha-2 adrenergic agonist-induced vasoconstriction by removal of endothelium in rat aorta. J. Pharmacol. Exp. Ther., 232, 682-687.
7. CASTRO, A., JIMENEZ, W., CLARIA, J., ROS, J., MARTINEZ, J.M., BOSCH, M., ARROYO, V., PIULATS, J., RIVERA, F. & J. RODES, J. (1993). Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. Hepatology, 18, 367-372.
8. CAWLEY, T., GERAGHTY, J., OSBORNE, H. & DOCHERTY, J.R. (1995). Effects of portal hypertension on responsiveness of rat mesenteric artery and aorta. Br. J. Pharmacol., 114, 791-796.
9. CRISCIONE, L., MULLER, K. & PRESCOTT, M.F. (1984). Endothelial cell loss enhances the pressor response in resistance vessels. J. Hypertens., 2, 441-444.
10. DANTHULURI, N.R. & DETH, R.C. (1984). Phorbol ester-induced contraction of arterial smooth muscle and inhibition of α-adrenergic response. Biochem. Biophys. Res. Commun., 125, 1103-1109.
11. DEMIREL, E., HINDIOGLU, F., ERCAN, Z.S. & TURKER, R.K. (1989). Endothelium modulates the effects of α-adrenoceptor agonists in vascular smooth muscle. Gen. Pharmacol., 20, 89-93.
12. GARCIA-SAINZ, J.A. (1991). Cell responsiveness and protein-kinase C: receptors, G proteins and membrane effectors. News Physiol. Sci., 6, 169-173.
13. HECKER, M., LUCKHOFF, A. & BUSSE, R. (1993). Modulation of endothelial autacoid release by protein kinase C: feedback inhibition or non-specific attenuation of receptor-dependent cell activation? J. Cell. Physiol., 156, 571-578.
14. HIRATA, M., KOHSE, K.P., CHANG, C. IKEBE, T. & MURAD, F. (1990). Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells. J. Biol. Chem., 265, 1268-1273.
15. HIRATA, K., KURODA, R., SAKODA, T., KATAYAMA, M., INOUE, N., SUEMATSU, M., KAWASHIMA, S. & YOKOYAMA, M. (1995). Inhibition of endothelial nitric oxide synthase activity by protein-kinase C. Hypertension, 25, 180-185.
16. HUANG, Y.-T., YU, P.-C., LEE, M.-G., LIN, H.C., HONG, C.-Y. & YANG, M.C.M. (1995). Decreased vascular contractile and inositol phosphate responses in portal hypertensive rats. Can. J. Physiol. Pharmacol., 73, 378-382.
17. KHALIL, R.A. & MORGAN, K.G. (1992). Protein-kinase C: a second E-C coupling pathway in vascular smooth muscle? News Physiol. Sci., 7, 10-15.
18. KOBAYASHI, E., NAKANO, H., MORIMOTO, M., TAMAOKI, T. (1992). Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun., 159, 548-553.
19. LAFFI, G., MARRA, F., FAILLI, P., RUGGIERO, M., CECCHI, E., CARLONI, V., GIOTTI, A. & GENTILINI, P. (1993). Defective signal transduction in platelets from cirrhotics is associated with increased cyclic nucleotides. Gastroenterology, 105, 148-156.
20. LANG, D. & LEWIS, M.J. (1991). Endothelium-derived relaxing factor inhibits the endothelin-1-induced increase in protein kinase C activity in rat aorta. Br. J. Pharmacol., 104, 139-144.
21. LANGLANDS, J.M. & DIAMOND, J. (1990). The effect of phenylephrine on inositol 1,4,5-trisphosphate levels in vascular smooth muscle measured using a protein binding assay system. Biochem. Biophys. Res. Commun., 173, 1258-1265.
22. LEE, F., ALBILLOS, A., COLOMBATO, L.A. & GROSZMANN, R.J. (1992). The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats. Hepatology, 16, 1043-1048.
23. LEE, M.W. & SEVERSON, D.L. (1994). Signal transduction in vascular smooth muscle: diacylglycerol second messengers and PKC action. Am. J. Physiol., 267, C659-C678.
24. 1-adrenoceptors of portal hypertensive rats. Br. J. Pharmacol., 111, 439-444.
25. MELKUMYANTS, A.M., BALASHOV, S.A. & KHAYUTIN, V.M. (1995). Control of arterial lumen by shear stress on endothelium. News Physiol. Sci., 10, 204-210.
26. MCGREGOR, D.D. (1965). The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric vessels of the rat. J. Physiol., 177, 21-30.
27. MOSCA, P., LEE, F., KAUMANN, A.J. & GROSZMANN, R.J. (1992). Pharmacology of portal-systemic collaterals in portal hypertensive rats: role of endothelium. Am. J. Physiol., 263, G544-G550.
28. MURRAY, B.M. & PALLER, M.S. (1985). Decreased pressor reactivity to angiotensin II in cirrhotic rats. Evidence for a post-receptor defect in angiotensin action. Circ. Res., 57, 424-431.
29. MURRAY, B.M. & PALLER, M.S. (1986). Pressor resistance to vasopressin in sodium depletion, potassium depletion and cirrhosis. Am. J. Physiol., 251, R525-R530.
30. PIZCUETA, M.P., CASAMITJANA, R., BOSCH, J. & RODES, J. (1990). Decreased systemic vascular sensitivity to norepinephrine in portal hypertensive rats: role of hyperglucagonism. Am. J. Physiol., 258, G191-G195.
31. PIZCUETA, M.P., PIQUE, J.M., BOSCH, J., WHITTLE, B.J.R. & MONCADA, S. (1992). Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension. Br. J. Pharmacol., 105, 184-190.
32. RAPOPORT, R.M. (1986). Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta. Circ. Res., 58, 407-410.
33. RASMUSSEN, H., TAKUWA, Y. & PARK, S. (1987). Protein kinase C in the regulation of smooth muscle contraction. FASEB J., 1, 177-185.
34. SHERIDAN, F., HORWITZ, L.D. & MCMURTRY, I.F. (1991). Effects of phorbol esters on canine coronary artery constriction and dilation in vitro. Am. J. Physiol., 261, H236-H242.
35. SHIMAMOTO, Y., SHIMAMOTO, H., KWAN, C. & DANIEL, E.E. (1993). Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle. Am. J. Physiol., 264, H1300-H1306.
36. SIEBER, C.C. & GROSZMANN, R.J. (1992). In vitro hyporeactivity to methoxamine in portal hypertensive rats: reversal by nitric oxide blockade. Am. J. Physiol., 262, G996-G1001.
37. SIKULER, E., KRAVETZ, D. & GROSZMANN, R.J. (1985). Evolution of portal hypertension and mechanism involved in its maintenance in a rat model. Am. J. Physiol., 248, G618-G625.
38. SITZMANN, J.V., LI, P.W. & LIN, P.W. (1989). Prostacyclin mediates splanchnic vascular response to norepinephrine in portal hypertension. J. Surg. Res., 47, 208-211.
39. SPINOZZI, F., BERTOTTO, A., RONDONI, F., GERLI, R., SCALISE, F. & GRIGNANI, E. (1991). T-lympkocyte activation pathways in alcoholic liver disease. Immunology, 73, 140-146.
40. VALLANCE, P. & MONCADA, S. (1991). Hyperdynamic circulation in cirrhosis: a role for nitric oxide? Lancet, 337, 777-778.
41. VILLALOBOS-MOLINA, R., RANSANZ, V., TORRES-MARQUEZ, M.E., HONG, E & GARCIA-SAINZ, A. (1990). Contrasting effects of phorbol dibutyrate and phorbol myristate acetate in rabbit aorta. Biochem. Biophys. Res. Commun., 171, 618-624.
42. VOROBIOFF, J., BREDFELDT, J.E. & GROSZMANN, R.J. (1983). Hyperdynamic circulation in portal hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am. J. Physiol., 244, G52-G57.
43. WILLIAMS, S.P., CAMPBELL, A.K., ROSZELL, N., MYATT, L., LEIKAUF, G.D. & RAPOPORT, R.M. (1994). Modulation of phorbol ester-induced contraction by endogenously released cyclo-oxygenase products in rat aorta. Am. J. Physiol., 267, H1654-H1662.
44. WU, Z. & BENOIT, J.N. (1994). Nonreceptor-mediated intestinal vasoconstriction in portal hypertensive rats. Am. J. Physiol., 267, H370-H375.