Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist

Journal of Medicinal Chemistry

Volumn 48, Issue 10, 2005, Pages 3478-3480

  Ward, Simon E ^a   Harrington, Frank P ^a   Gordon, Laurie J ^a   Hopley, Susanna C ^a   Scott, Claire M ^a   Watson, Jeannette M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SB 272183; SB 649915; SB 714786; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN;

ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; CRICETULUS; PIPERAZINES; QUINOLINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18644378747     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049039v     Document Type: Article

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