Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia

Leukemia

Volumn 19, Issue 5, 2005, Pages 806-813

  Prima, V ^a   Gore, L ^b,c   Caires, A ^b   Boomer, T ^b   Yoshinari, M ^d   Imaizumi, M ^e   Varella Garcia, M ^b,c   Hunger, S P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^d TOHOKU UNIVERSITY HOSPITAL   (Japan)

^e MIYAGI CHILDREN S HOSPITAL   (Japan)

Author keywords

Chromosomal translocation; Leukemogenesis; Oncogene

Indexed keywords

CELL PROTEIN; DELETED IN AZOOSPERMIA ASSOCIATED PROTEIN 1; DNA; DNA BINDING PROTEIN; HYBRID PROTEIN; MYOCYTE ENHANCER FACTOR 2D; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SEQUENCE; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CHROMOSOME 19P; CHROMOSOME 1Q; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; LEUKEMIA CELL LINE; LEUKEMOGENESIS; MITOGENESIS; MOLECULAR CLONING; MUSCLE CELL; NERVE CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TESTIS; WILD TYPE;

EID: 18644373523     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403684     Document Type: Article

References (52)

1. Rabbitts TH. Chromosomal translocations in human cancer. Nature 1994; 372: 143-149.
2. Hunger SP. Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. Blood 1996; 87: 1211-1224.
3. Carroll AJ, Crist WM, Parmley RT, Roper M, Cooper MD, Finley WH. Pre-B cell leukemia associated with chromosome translocation 1;19. Blood 1984; 63: 721-724.
4. Michael PM, Levin MD, Garson OM. Translocation 1;19 - a new cytogenetic abnormality in acute lymphocytic leukemia. Cancer Genet Cytogenet 1984; 12: 333-341.
5. Mellentin JD, Murre C, Donlon TA, McCaw PS, Smith SD, Carroll AJ et al. The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias. Science 1989; 246: 379-382.
6. Nourse J, Mellentin JD, Galili N, Wilkinson J, Stanbridge E, Smith SD et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 1990; 60: 535-545.
7. Kamps MP, Murre C, Sun XH, Baltimore D. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 1990; 60: 547-555.
8. Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP, Cleary ML. The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood 1991; 77: 687-693.
9. Kamps MP, Baltimore D. E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice. Mol Cell Biol 1993; 13: 351-357.
10. Dedera DA, Waller EK, LeBrun DP, Sen-Majumdar A, Stevens ME, Barsh GS et al. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice [published erratum appears in Cell 1993 Nov 19;75(4):826]. Cell 1993; 74: 833-843.
11. Privitera E, Kamps MP, Hayashi Y, Inaba T, Shapiro LH, Raimondi SC et al. Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia. Blood 1992; 79: 1781-1788.
12. Yoshinari M, Imaizumi M, Eguchi M, Ogasawara M, Salto T, Suzuki H et al. Establishment of a novel cell line (TS-2) of pre-B acute lymphoblastic leukemia with a t(1;19) not involving the E2A gene. Cancer Genet Cytogenet 1998; 101: 95-102.
13. Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development 1993; 118: 1095-1106.
14. Martin JF, Miano JM, Hustad CM, Copeland NG, Jenkins NA, Olson EN. A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol Cell Biol 1994; 14: 1647-1656.
15. McKinsey TA, Zhang CL, Olson EN. MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends Biochem Sci 2002; 27: 40-47.
16. Lund AH, Turner G, Trubetskoy A, Verhoeven E, Wientjens E, Hulsman D et al. Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet 2002; 32: 160-165.
17. Suzuki T, Shen H, Akagi K, Morse HC, Malley JD, Naiman DQ et al. New genes involved in cancer identified by retroviral tagging. Nat Genet 2002; 32: 166-174.
18. Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH. Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. Genomics 2000; 65: 266-273.
19. Vera Y, Dai T, Hikim AP, Lue Y, Salido EC, Swerdloff RS et al. Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation. J Androl 2002; 23: 622-628.
20. Jack I, Seshadri R, Garson M, Michael P, Callen D, Zola H et al. RCH-ACV: a lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8. Cancer Genet Cytogenet 1986; 19: 261-269.
21. Ashworth LK, Batzer MA, Brandriff B, Branscomb E, de Jong P, Garcia E et al. An integrated metric physical map of human chromosome 19. Nat Genet 1995; 11: 422-427.
22. Boomer T, Varella-Garcia M, McGavran L, Meltesen L, Olsen AS, Hunger SP. Detection of E2A translocations in leukemias via fluorescence in situ hybridization. Leukemia 2001; 15: 95-102.
23. Maloney KW, McGavran L, Murphy JM, Odom LF, Stork L, Wei Q et al. TEL-AML1 fusion identifies a subset of children with standard risk acute lymphoblastic leukemia who have an excellent prognosis when treated with therapy that includes a single delayed intensification. Leukemia 1999; 13: 1708-1712.
24. Hunger SP, Ohyashiki K, Toyama K, Cleary ML. Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev 1992; 6: 1608-1620.
25. Hunger SP, Brown R, Cleary ML. DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. Mol Cell Biol 1994; 14: 5986-5996.
26. Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. Blood 1996; 87: 4607-4617.
27. McCombie WR, Heiner C, Kelley JM, Fitzgerald MG, Gocayne JD. Rapid and reliable fluorescent cycle sequencing of double-stranded templates. DNA Seq 1992; 2: 289-296.
28. Shore P, Sharrocks AD. The MADS-box family of transcription factors. Eur J Biochem 1995; 229: 1-13.
29. Black BL, Olson EN. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol 1998; 14: 167-196.
30. Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD et al. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 1992; 257: 531-534.
31. Wan L, Kim JK, Pollard VW, Dreyfuss G. Mutational definition of RNA-binding and protein-protein interaction domains of heterogeneous nuclear RNP C1. J Biol Chem 2001; 276: 7681-7688.
32. Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. Immunity 1998; 8: 703-711.
33. Youn HD, Sun L, Prywes R, Liu JO. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science 1999; 286: 790-793.
34. Youn HD, Chatila TA, Liu JO. Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J 2000; 19: 4323-4331.
35. Youn HD, Grozinger CM, Liu JO. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. J Biol Chem 2000; 275: 22563-22567.
36. Bour BA, O'Brien MA, Lockwood WL, Goldstein ES, Bodmer R, Taghert PH et al. Drosophila MEF2, a transcription factor that is essential for myogenesis. Genes Dev 1995; 9: 730-741.
37. Lilly B, Zhao B, Ranganayakulu G, Paterson BM, Schulz RA, Olson EN. Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science 1995; 267: 688-693.
38. Lin Q, Schwarz J, Bucana C, Olson EN. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 1997; 276: 1404-1407.
39. Mao Z, Bonni A, Xia F, Nadal-Vicens M, Greenberg ME. Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science 1999; 286: 785-790.
40. Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell Biol 1995; 15: 6364-6376.
41. Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J et al. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci USA 2002; 99: 3974-3979.
42. Han TH, Prywes R. Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol Cell Biol 1995; 15: 2907-2915.
43. Pan F, Ye Z, Cheng L, Liu JO. Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT). J Biol Chem 2004; 279: 14477-14480.
44. Nagai K, Oubridge C, Ito N, Avis J, Evans P. The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA. Trends Biochem Sci 1995; 20: 235-240.
45. Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M et al. Gene fusion with ah ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992; 359: 162-165.
46. Ron D. TLS-CHOP and the role of RNA-binding proteins in oncogenic transformation. Curr Top Microbiol Immunol 1997; 220: 131-142.
47. Mercher T, Coniat MB, Monni R, Mauchauffe M, Khac FN, Gressin L et al. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci USA 2001; 98: 5776-5779.
48. Barbouti A, Hoglund M, Johansson B, Lassen C, Nilsson PG, Hagemeijer A et al. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). Cancer Res 2003; 63: 1202-1206.
49. Miyamoto K, Tomita N, Ishii A, Nonaka H, Kondo T, Tanaka T et al. Chromosome abnormalities of leukemia cells in adult patients with T-cell leukemia. J Natl Cancer Inst 1984; 73: 353-362.
50. Vagner-Capodano AM, Mozziconacci MJ, Zattara-Cannoni H, Guitard AM, Thuret I, Michel G. t(1;19) in a M4-ANLL [letter]. Cancer Genet Cytogenet 1994; 73: 86-88.
51. Wlodarska I, Stul M, De Wolf-Peeters C, Verhoef G, Mecucci C, Cassiman JJ et al. t(1 ;19) without detectable E2A rearrangements in two t(14;18)-positive lymphoma/leukemia cases [see comments]. Genes Chromosomes Cancer 1994; 10: 171-176.
52. Yuki Y, Imoto I, Imaizumi M, Hibi S, Kaneko Y, Amagasa T et al. Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13). Cancer Sci 2004; 95: 503-507.