Assessment of the ability of the antioxidant cocktail-derived from fermentation of plants with effective microorganisms (EM-X) to modulate oxidative damage in the kidney and liver of rats in vivo: Studies upon the profile of poly- and mono-unsaturated fatty acids

Toxicology Letters

Volumn 135, Issue 3, 2002, Pages 209-217

  Aruoma, Okezie I ^a   Deiana, Monica ^b   Rosa, Antonella ^b   Casu, Viviana ^b   Piga, Rosaria ^b   Peccagnini, Stefania ^b   Dessì, M Assunta ^b   Ke, Bin ^c   Liang, Yun Fei ^d   Higa, Terou ^d  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c EM Research Organization Inc   (Japan)

^d UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Antioxidants; Cancer; EM X; Flavonoids; Glutathione; Iron toxicity; Nitrilotriacetic acid; Oxidative stress; Polyunsaturated fatty acids; Vitamin E

Indexed keywords

ALKADIENE; ANTIOXIDANT; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; LINOLEIC ACID; MONOUNSATURATED FATTY ACID; NITRILOTRIACETATE IRON; OLEIC ACID; POLYUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; FERMENTATION; IN VIVO STUDY; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; MICROORGANISM; NONHUMAN; OXIDATION; PLANT; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTIOXIDANTS; CARICA; FATTY ACIDS, UNSATURATED; FERMENTATION; FERRIC COMPOUNDS; INJECTIONS, INTRAPERITONEAL; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; NITRILOTRIACETIC ACID; ORYZA SATIVA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHYTOTHERAPY; PLANTS; RATS; RATS, WISTAR; SEAWEED;

CARICA PAPAYA; PHOTOBACTERIA;

EID: 18644365987     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00261-8     Document Type: Article

References (27)

1. Aruoma O.I. Free radicals, oxidative stress and antioxidants in health and disease. J. Am. Oil Chem. Soc. 75:1998;199-212.
2. Aruoma O.I. Free radicals, antioxidants and international nutrition. Asia Pacific J. Clin. Nutr. 8:1999;53-63.
3. Aruoma O.I., Halliwell B. Molecular Biology of Free Radicals in Human Diseases. 1998;OICA International, London.
4. Banni S., Day B.W., Evans R.W., Corongiu F.P., Lombardi B. Liquid chromatography-mass spectrometric analysis of conjugated diene fatty acids in a partially hydrogenated fat. J. Am. Oil Chem. Soc. 71:1994;1321-1325.
5. Banni S., Carta G., Contini M.S., Angioni E., Deiana M., Dessì M.A., Melis M.P., Corongiu F.P. Characterization of conjugated diene fatty acids in milk, dairy products and lamb tissues. J. Nutr. Biochem. 7:1996;150-155.
6. Bray T.M., Schoene N.W. Models and Methods in Cell Signaling and Gene Expression: Applications to Oxidative Stress Research. 2000;OICA International, London.
7. Cantuti-Castelvetri I., Shukitt-Halle B., Joseph J.A. Neurobehavioral aspects of antioxidants in aging. Int. J. Dev. Neurosci. 18:2000;367-381.
8. Chiang S.D., Gessert C.F., Lowry O.H. Colorimetric determination of extracted lipids. An adaptation for microgram amounts of lipids obtained from cerumen. Curr. List Med. Lit. Res. Rep. 33:1957;56-64.
9. Corongiu F.P., Banni S. Detection of conjugated dienes by second derivative ultraviolet spectrophotometry. Methods Enzymol. 233:1994;303-310.
10. Deiana M., Aruoma O.I., Rosa A., Crobu V., Casu V., Piga R., Dessi M.A. The effect of ferric-nitrilotriacetic acid on the profile of polyunsaturated fatty acids in the kidney and liver of rats. Toxicol. Lett. 123:2001;125-133.
11. Ebina Y., Okada S., Hamazaki S., Ogino F., Li J.-L., Midorikawa O. Nephrotoxicity and renal cell carcinoma after use of iron and aluminum-nitrilotriacetate complexes in rats. J. Natl. Cancer Inst. 76:1986;107-113.
12. Folch J., Lees M., Sloane-Stanley G.H. A simple method for the isolation and purification of total lipid from animals tissues. J. Biol. Chem. 226:1957;497-509.
13. Higa T., Ke B. Clinical and Basic Medical Research on EM-X - a Collection of Research Papers. 1:2001;EMRO, Okinawa, Japan.
14. Ikeda K., Sun F., Tanaka K., Tokumaru S., Kojo S. Increase of lipid hydroperoxides in the rat liver and kidney after administering ferric nitrilotriacetate. Biosci. Biotechnol. Biochem. 62:1998;1438-1439.
15. Jollow D.J., Mitchell J.R., Zampaglione N., Gillete J.R. Bromobenzene-induced liver necrosis: protective role of glutathione and evidence for 3,4 bromobenzeneoxide as the hepatotoxic intermediate. Pharmacology. 11:1974;151-169.
16. Ke B., Higa T., Zhong Z.-X., Liang Y.-F. Anti-aging activities of effective microorganisms extracts (EM-X) on the fruit and the mouse. J. Snake. 13:2001;1-8.
17. Li J.-L., Okada S., Hamazaki S., Ebina Y., Midorikawa O. Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res. 47:1987;1867-1869.
18. Milchak L.M., Bricker J.D. The effects of glutathione and vitamin E on iron toxicity in isolated rat hepatocytes. Toxicol. Lett. 126:2002;169-177.
19. Okada S., Minamiyama Y., Hamazaki S., Toyokuni S., Sotomatsu A. Glutathione cycle dependency of ferric nitrilotriacetate-induced lipid peroxidation in mouse proximal renal tubules. Arch. Biochem. Biophys. 301:1993;138-142.
20. Pryor W.A. Vitamin E and heart disease: basic science to clinical intervention trials. Free Radic. Biol. Med. 28:2000;141-164.
21. Shiomi K., Shen B., Toyokuni S., Mochizuki R., Furugori M. Protection by αG-rutin, a water soluble antioxidant flavonoid, against renal damage in mice treated with ferric nitrilotriacetate. Jpn. J. Cancer. Res. 88:1997;453-460.
22. The Eye Disease Case-Control Study Group, Seddon J.M., Ajani U.A., Sperduto R.D., Hiller R., Blair N., Burton T.C., Farber M.D., Gragoudas E.S., Haller J., Miller D.T., Yannuzzi L.A., Willett W. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. J. Am. Med. Assoc. 272:1994;1413-1420.
23. Taylor S.L., Lamden M.P., Tappel A.L. Sensitive fluorimetric method for tissue tocopherol analysis. Lipids. 11:1976;530-534.
24. Toyokuni S., Tanaka T., Nishiyama Y., Okamoto K., Nakashima Y., Hamazaki S., Okada S., Hiai H. Induction of renal cell carcinoma in male wister rats treated with cupric nitrilotriacetate. Lab. Invest. 75:1996;239-248.
25. Totokuni S., Itani T., Morimitsu Y., Okada K., Ozeki M., Kondo S., Uchida K., Osawa T., Hiai H., Tashiro T. Protective effect of coloured rice over white rice on Fento reaction-based renal lipid peroxidation in rats. Free Radic. Res. 36:2002;583-592.
26. Zhang D., Yasuda T., Yu Y., Zheng P., Kawabata T., Ma Y., Okada S. Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation. Free Radic. Biol. Med. 20:1996;145-150.
27. Zhong, Z.-X., Ke, B., Higa, T., Zhou, G.-F., Cheng, X.-F., 1999. Study on toxicological tests of EM-X. Proceedings of the fifth International Congress on Ecology and Cancer, Asian Chapter, Okinawa, Japan, p. 53.