Cross-linking of amidated low-methoxylated pectin with calcium during extrusion/spheronisation: Effect on particle size and shape

Chemical Engineering Science

Volumn 60, Issue 14, 2005, Pages 3899-3907

  Tho, Ingunn ^a,b   Sande, Sverre Arne ^b   Kleinebudde, Peter ^c  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Agglomeration; Extrusion; Formulation; Granulation; Pellets; Spheronisation

Indexed keywords

CALCIUM; CROSSLINKING; DRUG PRODUCTS; EXTRUSION; PARTICLE SIZE ANALYSIS;

AMIDATED LOW-METHOXYLATED PECTIN; CALCIUM IONS; POWDER MIXTURE; WET EXTRUSION;

PELLETIZING;

CROSSLINKING;

EID: 18644364223     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2005.02.023     Document Type: Conference Paper

References (35)

1. A.M. Agrawal, M.A. Howard, and S.H. Neau Extruded and spheronized beads containing no microcrystalline cellulose: influence of formulation and process variables Pharmaceutical Development and Technology 9 2004 197 217
2. M.A.V. Axelos, and M. Kolb Cross-linked biopolymers: experimental evidence for scalar percolation theory Physical Review Letters 64 1990 1457 1460
3. M.A.V. Axelos, and J.F. Thibault The chemistry of low-methoxyl pectin gelation R.H. Walter The Chemistry and Technology of Pectin 1991 Academic Press San Diego 109 118
4. Bornhöft, M., Kleinebudde, P., 2002. Assessment of k-carrageenan as alternative extrusion aid to microcrystalline cellulose. Proceedings of the 4th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, vol. 4, pp. 623-624.
5. Bornhöft, M., Thommes, M, Kleinebudde, P., 2004. Preliminary assessment of carrageenan as excipient for extrusion/spheronisation. European Journal of Pharmaceutics and Biopharmaceutics 59, 127-131.
6. R. Chopra, F. Podczeck, J.M. Newton, and G. Alderborn The influence of pellet shape and film coating on the filling of pellets into hard shell capsules European Journal of Pharmaceutics and Biopharmaceutics 53 2002 327 333
7. A.H. Clark, and D.B. Farrer Shear modulus-concentration relationships for low DE pectin-calcium gels in the temperature range 20-85°C. Food Hydrocolloids 10 1996 31 39
8. K. Esbensen, S. Schoenkopf, T. Midtgarard, and D. Guyot Multivariate Analysis in Practice 1994 Camo ASA Trondheim
9. C. Garnier, M.A.V. Axelos, and J.-F. Thibault Phase diagrams of pectin-calcium systems influence of pH, ionic strength, and temperature on the gelation of pectins with different degrees of methylation Carbohydrate Research 240 1993 219 232
10. S.R. Goskonda, and S.M. Upadrashta Avicel RC-591/Chitosan beads by extrusion-spheronization technology Drug Development and Industrial Pharmacy 19 1993 915 927
11. G.T. Grant, E.R. Morris, D.A. Rees, P.J.C. Smith, and D. Thom Biological interactions between polysaccharides and divalent cations: the egg-box model FEBS Letter 32 1973 195 198
12. G.G. Hammes, and J.C. Swann Influence of denaturing agents on solvent structure Biochemistry 6 1967 1591 1596
13. D.C. Hicks, and H.L. Freese Extrusion and spheronizing equipment I. Ghebre-Sellassie Pharmaceutical Pelletization Technology 1989 Marcel Dekker New York 71 100
14. G.A. Hileman, S.M. Upadrashta, and S.H. Neau Drug solubility effects on predicting optimum conditions for extrusion and spheronization of pellets Pharmaceutical Development and Technology 2 1997 43 52
15. K.N. Kirschner, and R.J. Woods Solvent interactions determine carbohydrate conformation Proceedings of the National Academy of Sciences of the United States of America 98 2001 10541 10545
16. A.-L. Kjøniksen, M. Hiorth, J. Roots, and B. Nyström Shear-induced association and gelation of aqueous solutions of pectin Journal of Physical Chemistry B 107 2003 6324
17. P. Kleinebudde Use of a power-consumption-controlled extruder in the development of pellet formulations Journal of Pharmaceutical Sciences 84 1995 1259 1264
18. D. Lootens, F. Capel, D. Durand, T. Nicolai, P. Boulenguer, and V. Langendorff Influence of pH, Ca-concentration, temperature and amidation on the gelation of low methoxyl pectin Food Hydrocolloids 17 2003 237 244
19. C. Lustig-Gustafsson, J.H. Kaur, F. Podczeck, and J.M. Newton The influence of water content and drug solubility on the formulation of pellets by extrusion and spheronisation European Journal of Pharmaceutical Sciences 8 1999 147 152
20. H. Martens, and M. Martens Modified Jack-knife estimation of parameter uncertainty in bilinear modelling by partial least squares regression (PLSR) Food Quality and Preference 11 2000 5 16
21. H. Martens, and T. Næs Multivariate Calibration 1989 Wiley and Sons Ltd.
22. E.R. Morris Conformations and interactions of pectins I. Polymorphism between gel and solid states of calcium polygalacturonate Journal of Molecular Biology 155 1982 507 516
23. F. Podczeck, S.R. Rahman, and J.M. Newton Evaluation of a standardised procedure to assess the shape of pellets using image analysis International Journal of Pharmaceutics 192 1999 123 138
24. D.A. Powell Conformations and interactions of pectins II. Influence of residue sequence on association in calcium pectate gels Journal of Molecular Biology 155 1982 517 531
25. M.-C. Ralet, V. Dronnet, H.C. Buchholt, and J.-F. Thibault Enzymatically and chemically de-esterified lime pectins characterisation, polyelectrolyte behaviour and calcium binding properties Carbohydrate Research 336 2001 117 125
26. J.C.E. Reitsma, J.F. Thibault, and W. Pilnik Properties of amidated pectins. I. Preparation and characterization of amidated pectins and amidated pectin acids Food Hydrocolloids 1 1986 121 127
27. A.D. Reynolds A new technique for the production of spherical particles Manufacturing Chemistry 41 6 1970 40 43
28. Rowe, R.C., 1985. Speronization: a novel pill-making process? Pharmacy International May, 119-123.
29. H. Santos, F. Veiga, M. Pina, F. Podczeck, and J. Sousa Physical properties of chitosan pellets produced by extrusion-spheronisation influence of formulation variables International Journal of Pharmaceutics 246 2002 153 169
30. H. Steckel, and F. Mindermann-Nogly Production of chitosan pellets by extrusion/spheronisation European Journal of Pharmaceutics and Biopharmaceutics 57 2004 107 114
31. C. Tapia, G. Buckton, and J.M. Newton Factors influencing the mechanism of release from sustained-release matrix pellets, produced by extrusion spheronization International Journal of Pharmaceutics 92 1993 211 218
32. I. Tho, E. Anderssen, K. Dyrstad, P. Kleinebudde, and S.A. Sande Quantum chemical descriptors in the formulation of pectin pellets produced by extrusion/spheronisation European Journal of Pharmaceutical Sciences 16 2002 143 149
33. I. Tho, S.A. Sande, and P. Kleinebudde Pectinic acid. A novel excipient for the production of pellets by extrusion/spheronisation Preliminary studies. European Journal of Pharmaceutics and Biopharmaceutics 54 2002 95 99
34. I. Tho, S.A. Sande, and P. Kleinebudde Disintegrating pellets from a water-insoluble pectin derivative produced by extrusion/spheronisation European Journal of Pharmaceutics and Biopharmaceutics 56 2003 371 380
35. Thommes, M., Bornhöft, M., Kleinebudde, P., 2004. K-carrageenan as extrusion aid: pellets with high drug load and effect of different excipients on dissolution profiles. Proceedings of the International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 825-826.