Production of chitosan pellets by extrusion/spheronization

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 57, Issue 1, 2004, Pages 107-114

  Steckel, H ^a   Mindermann Nogly, F ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Chitosan; Extrusion spheronization; Microcrystalline cellulose; Pellet; Porosity

Indexed keywords

ACETIC ACID; CHITOSAN; MICROCRYSTALLINE CELLULOSE; WATER;

ARTICLE; DRUG SYNTHESIS; PHYSICAL CHEMISTRY; POWDER; SOLUBILITY; SPHERONIZATION;

EID: 0347985634     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(03)00156-5     Document Type: Article

References (17)

1. Hirano S., Seino H., Akiyama Y., Nonaka I. Chitosan: A biocompatible material for oral and intravenous administrations. Progress in Biomedical Polymers. 1990;Plenum, New York.
2. He P., Davis S.S., Illum L. Chitosan microspheres prepared by spray drying. Int. J. Pharm. 187:1999;53-65.
3. Hejazi R., Amiji M. Stomach-specific anti-H. pylori therapy. I: preparation and characterisation of tetracycline-loaded chitosan microspheres. Int. J. Pharm. 235:2002;87-94.
4. Inoyatov N., Celebi N., Acarturk F. Preparation and evaluation of a prolonged release pentoxyphyllin tablet with chitosan. Pharm. Ind. 60:(5):1998;472-475.
5. Säkkinen M., Seppälä U., Heinänen P., Marvola M. In vitro evaluation of microcrystalline chitosan as gel-forming excipient in matrix granules. Eur. J. Pharm. Biopharm. 54:2002;33-40.
6. Follonier N., Doelker E. Biopharmaceutical comparison of an oral multiple-unit and single-unit sustained-release dosage forms. STP Pharma Sci. 2:1992;141-158.
7. Berthold A., Cremer K., Kreuter J. Preparation and characterisation of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs. J. Controlled Release. 39:1996;17-25.
8. H.-R. Hoffmann, B, Asmussen, Schnellzerfallende Pellets auf der Basis von Chitosan, Patent DE 199/40795 A1, 1999.
9. N. Shimono, M. Mori, Y. Higashi, Solid preparations containing chitosan powder and process for producing the same, Patent WO 01/10467, 1999.
10. Tapia C., Buckton G., Newton J.M. Factors influencing the mechanism of release from sustained release matrix pellets, produced by extrusion/ spheronization. Int. J. Pharm. 92:1993;211-218.
11. Goskonda S.R., Upadrashta S.M. Avicel RC-591/Chitosan beads by extrusion-spheronization technology. Drug Dev. Ind. Pharm. 19:(8):1993;915-927.
12. Chatchawalsaisin J., Podczeck F., Newton J.M. The influence of chitosan, sodium alginate and formulation variables on the formulation and drug release from pellets. 3rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Berlin. 2000.
13. Santos H., Veiga F., Pina M., Podczeck F., Sousa J. Physical properties of chitosan pellets produced by extrusion-spheronisation: influence of formulation variables. Int. J. Pharm. 246:2002;153-169.
14. Lindner H. Entwicklung eines leistungsgeregelten Zweischneckenextruders zur Herstellung pharmazeutischer Pellets. Dissertation. 1993;Kiel University, Kiel.
15. Lindner H., Kleinebudde P. Anwendung der automatischen Bildanalyse zur Charakterisiserung von Pellets. Pharm. Ind. 55:1993;694-701.
16. Schultz P., Kleinebudde P. Development of a new pellet friability tester. Pharm. Ind. 57:1994;323-328.
17. Nymo L., Schröder M., Schultz P., Müller B., Waaler T., Kleinebudde P. Properties of extruded pellets made from binary mixtures. Proc. 1st World Meeting, APGI/APV. 1995.