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Volumn 10, Issue 2, 2003, Pages 285-291

Expression of bcl-2 in oral squamous cell carcinoma: An immunohistochemical study of 90 cases with clinico-pathological correlations

Author keywords

Apoptosis; Bcl 2; Mouth; Oral mucosa; Squamous cell carcinoma

Indexed keywords

PROTEIN BCL 2;

EID: 18544411903     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.10.2.285     Document Type: Article
Times cited : (31)

References (51)
  • 1
    • 0028326952 scopus 로고
    • An evolutionary perspective on apoptosis
    • DOI 10.1016/0092-8674(94)90350-6
    • Vaux DL, Haecker G and Strasser A: An evolutionary perspective on apoptosis. Cell 76: 777-779, 1994. (Pubitemid 24085313)
    • (1994) Cell , vol.76 , Issue.5 , pp. 777-779
    • Vaux, D.L.1    Haecker, G.2    Strasser, A.3
  • 4
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462, 1995.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 5
    • 0029899181 scopus 로고    scopus 로고
    • Molecular thanatopsis: A discourse on the BCL2 family and cell death
    • Yang E and Korsmeyer SJ: Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 88: 386-401, 1996. (Pubitemid 26240369)
    • (1996) Blood , vol.88 , Issue.2 , pp. 386-401
    • Yang, E.1    Korsmeyer, S.J.2
  • 6
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie AH: Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556, 1980.
    • (1980) Nature , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 7
    • 0027217084 scopus 로고
    • Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
    • Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Wakeling AE, Walker PR and Sikorska M: Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 12: 3679-3684, 1993. (Pubitemid 23256455)
    • (1993) EMBO Journal , vol.12 , Issue.9 , pp. 3679-3684
    • Oberhammer, F.1    Wilson, J.W.2    Dive, C.3    Morris, I.D.4    Hickman, J.A.5    Wakeling, A.E.6    Walker, P.R.7    Sikorska, M.8
  • 8
    • 0029125701 scopus 로고
    • Protease activation during apoptosis: Death by a thousand cuts?
    • Martin SJ and Green DR: Protease activation during apoptosis: death by a thousand cuts? Cell 82: 349-352, 1995.
    • (1995) Cell , vol.82 , pp. 349-352
    • Martin, S.J.1    Green, D.R.2
  • 9
    • 0028939862 scopus 로고
    • The genetic regulation of apoptosis
    • Wyllie AH: The genetic regulation of apoptosis. Curr Opin Genet Dev 5: 97-104, 1995.
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 97-104
    • Wyllie, A.H.1
  • 10
    • 0027449187 scopus 로고
    • Induction of apoptosis in fibroblasts by IL-1beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
    • DOI 10.1016/0092-8674(93)90486-A
    • Miura M, Zhu H, Rotello R, Hartwieg EA and Yuan J: Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75: 653-660, 1993. (Pubitemid 23346364)
    • (1993) Cell , vol.75 , Issue.4 , pp. 653-660
    • Miura, M.1    Zhu, H.2    Rotello, R.3    Hartwieg, E.A.4    Yuan, J.5
  • 11
    • 0031809920 scopus 로고    scopus 로고
    • Mechanisms controlling cellular suicide: Role of Bcl-2 and caspases
    • DOI 10.1007/s000180050171
    • Allen RT, Cluck MW and Agrawal DK: Mechanisms controlling cellular suicide: role of Bcl-2 and caspases. Cell Mol Life Sci 54: 427-445, 1998. (Pubitemid 28260595)
    • (1998) Cellular and Molecular Life Sciences , vol.54 , Issue.5 , pp. 427-445
    • Allen, R.T.1    Cluck, M.W.2    Agrawal, D.K.3
  • 12
    • 0031575073 scopus 로고    scopus 로고
    • Promise and problems of Bcl-2 antisense therapy
    • Reed JC: Promise and problems of Bcl-2 antisense therapy. J Natl Cancer Inst 89: 988-990, 1997.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 988-990
    • Reed, J.C.1
  • 13
    • 0032409781 scopus 로고    scopus 로고
    • Bcl-2 family proteins
    • Reed JC: Bcl-2 family proteins. Oncogene 17: 3225-3236, 1998.
    • (1998) Oncogene , vol.17 , pp. 3225-3236
    • Reed, J.C.1
  • 14
    • 0027537461 scopus 로고
    • An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
    • Crook NE, Clem RJ and Miller LK: An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J Virol 67: 2168-2174, 1993. (Pubitemid 23088392)
    • (1993) Journal of Virology , vol.67 , Issue.4 , pp. 2168-2174
    • Crook, N.E.1    Clem, R.J.2    Miller, L.K.3
  • 15
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux DL, Cory S and Adams JM: Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442, 1988.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 16
    • 0032410818 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) and their emerging role in cancer
    • La Casse EC, Baird S, Korneluk RG and MacKenzie AE: The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 17: 3247-3259, 1998. (Pubitemid 29043977)
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3247-3259
    • LaCasse, E.C.1    Baird, S.2    Korneluk, R.G.3    MacKenzie, A.E.4
  • 18
    • 0034142099 scopus 로고    scopus 로고
    • Dysregulated expression of bcl-2 and bax in oral carcinomas: Evidence of post-transcriptional control
    • DOI 10.1034/j.1600-0714.2000.290203.x
    • Chen Y, Kayano T and Takagi M: Dysregulated expression of bcl-2 and bax in oral carcinomas: evidence of post-transcriptional control. J Oral Pathol Med 29: 63-69, 2000. (Pubitemid 30104869)
    • (2000) Journal of Oral Pathology and Medicine , vol.29 , Issue.2 , pp. 63-69
    • Chen, Y.1    Kayano, T.2    Takagi, M.3
  • 20
    • 0031788261 scopus 로고    scopus 로고
    • Overexpression of cyclin-D1, bcl-2, and bax proteins, proliferating cell nuclear antigen (PCNA), and DNA-ploidy in squamous cell carcinoma of the oral cavity
    • Staibano S, Mignogna MD, Lo Muzio L, Di Alberti L, Di Natale E, Lucariello A, Mezza E, Bucci E and De Rosa G: Overexpression of cyclin-D1, bcl-2, and bax proteins, proliferating cell nuclear antigen (PCNA), and DNA-ploidy in squamous cell carcinoma of the oral cavity. Hum Pathol 29: 1189-1194, 1998. (Pubitemid 28525516)
    • (1998) Human Pathology , vol.29 , Issue.11 , pp. 1189-1194
    • Staibano, S.1    Mignogna, M.D.2    Lo, M.L.3    Di, A.L.4    Di, N.E.5    Lucariello, A.6    Mezza, E.7    Bucci, E.8    Derosa, G.9
  • 21
    • 0021821903 scopus 로고
    • Involvement of the bcl-2 gene in human follicular lymphoma
    • Tsujimoto Y, Cossman J, Jaffe E and Croce CM: Involvement of the bcl-2 gene in human follicular lymphoma. Science 228: 1440-1443, 1985. (Pubitemid 15041322)
    • (1985) Science , vol.228 , Issue.4706 , pp. 1440-1443
    • Tsujimoto, Y.1    Cossman, J.2    Jaffe, E.3    Croce, C.M.4
  • 22
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D, Nunez G, Milliman C, Schreiber RD and Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336, 1990. (Pubitemid 120029101)
    • (1990) Nature , vol.348 , Issue.6299 , pp. 334-336
    • Hockenbery, D.1    Ninez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 23
    • 0027362667 scopus 로고
    • Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
    • Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W and Reed JC: Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 53: 4701-4714, 1993. (Pubitemid 23304404)
    • (1993) Cancer Research , vol.53 , Issue.18 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 24
    • 0028814112 scopus 로고
    • Immunohistochemical analysis of the Bcl-2 oncoprotein in human neuroblastomas. Comparisons with tumor cell differentiation and N-Myc protein
    • Krajewski S, Chatten J, Hanada M and Reed JC: Immunohistochemical analysis of the Bcl-2 oncoprotein in human neuroblastomas. Comparisons with tumor cell differentiation and N-Myc protein. Lab Invest 72: 42-54, 1995.
    • (1995) Lab Invest , vol.72 , pp. 42-54
    • Krajewski, S.1    Chatten, J.2    Hanada, M.3    Reed, J.C.4
  • 26
    • 0029077154 scopus 로고
    • Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis
    • Lipponen P, Pietilainen T, Kosma VM, Aaltomaa S, Eskelinen M and Syrjanen K: Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis. J Pathol 177: 49-55, 1995.
    • (1995) J Pathol , vol.177 , pp. 49-55
    • Lipponen, P.1    Pietilainen, T.2    Kosma, V.M.3    Aaltomaa, S.4    Eskelinen, M.5    Syrjanen, K.6
  • 27
    • 0028793408 scopus 로고
    • Nuclear and cytoplasmic bcl-2 expression in endometrial hyperplasia and adenocarcinoma
    • Chan WK, Mole MM, Levison DA, Ball RY, Lu QL, Patel K and Hanby AM: Nuclear and cytoplasmic bcl-2 expression in endometrial hyperplasia and adenocarcinoma. J Pathol 177: 241-246, 1995.
    • (1995) J Pathol , vol.177 , pp. 241-246
    • Chan, W.K.1    Mole, M.M.2    Levison, D.A.3    Ball, R.Y.4    Lu, Q.L.5    Patel, K.6    Hanby, A.M.7
  • 28
    • 0028814213 scopus 로고
    • The bcl-2 protooncogene and the gastrointestinal epithelial tumor progression model
    • Bronner MP, Culin C, Reed JC and Furth EE: The bcl-2 protooncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 146: 20-26, 1995.
    • (1995) Am J Pathol , vol.146 , pp. 20-26
    • Bronner, M.P.1    Culin, C.2    Reed, J.C.3    Furth, E.E.4
  • 29
    • 0028934199 scopus 로고
    • Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma
    • Tron VA, Krajewski S, Klein-Parker H, Li G, Ho VC and Reed JC: Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma. Am J Pathol 146: 643-650, 1995.
    • (1995) Am J Pathol , vol.146 , pp. 643-650
    • Tron, V.A.1    Krajewski, S.2    Klein-Parker, H.3    Li, G.4    Ho, V.C.5    Reed, J.C.6
  • 33
    • 0034051179 scopus 로고    scopus 로고
    • Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma
    • Stoll C, Baretton G, Ahrens C and Lohrs U: Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma. Virchows Arch 436: 102-108, 2000. (Pubitemid 30128755)
    • (2000) Virchows Archiv , vol.436 , Issue.2 , pp. 102-108
    • Stoll, C.1    Baretton, G.2    Ahrens, C.3    Lohrs, U.4
  • 35
    • 0032589824 scopus 로고    scopus 로고
    • Bcl-x(L) and Bcl-2 expression in squamous cell carcinoma of the head and neck
    • DOI 10.1002/(SICI)1097-0142(19990101)85:1<164::
    • Pena JC, Thompson CB, Recant W, Vokes EE and Rudin CM: Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck. Cancer 85: 164-170, 1999. (Pubitemid 29031371)
    • (1999) Cancer , vol.85 , Issue.1 , pp. 164-170
    • Pena, J.C.1    Thompson, C.B.2    Recant, W.3    Vokes, E.E.4    Rudin, C.M.5
  • 36
    • 0032441217 scopus 로고    scopus 로고
    • p53 and bcl-2 expression in locally advanced squamous cell head-neck cancer treated with platinum based chemotherapy and radiotherapy
    • Giatromanolaki A, Koukourakis M, Zaramboukas T, Skordalaki A, Arapantoni P, Georgoulias V and Fountzilas G: p53 and bcl-2 expression in locally advanced squamous cell head-neck cancer treated with platinum based chemotherapy and radiotherapy. Anticancer Res 18: 4685-4692, 1998. (Pubitemid 29042044)
    • (1998) Anticancer Research , vol.18 , Issue.6 B , pp. 4685-4692
    • Giatromanolaki, A.1    Koukourakis, M.2    Zaramboukas, T.3    Skordalaki, A.4    Arapantoni, P.5    Georgoulias, V.6    Fountzilas, G.7
  • 38
    • 0032168568 scopus 로고    scopus 로고
    • Expression of bcl-2 oncoprotein in Indian oral squamous cell carcinomas
    • DOI 10.1016/S1368-8375(98)00037-2, PII S1368837598
    • Kannan K, Latha PN and Shanmugam G: Expression of bcl-2 oncoprotein in Indian oral squamous cell carcinomas. Oral Oncol 34: 373-376, 1998. (Pubitemid 28440298)
    • (1998) Oral Oncology , vol.34 , Issue.5 , pp. 373-376
    • Kannan, K.1    Latha, P.N.L.2    Shanmugam, G.3
  • 40
    • 0032887214 scopus 로고    scopus 로고
    • Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis
    • DOI 10.1016/S0046-8177(99)90229-0
    • Loro LL, Vintermyr OK, Liavaag PG, Jonsson R and Johannessen AC: Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis. Hum Pathol 30: 1097-1105, 1999. (Pubitemid 29427168)
    • (1999) Human Pathology , vol.30 , Issue.9 , pp. 1097-1105
    • Loro, L.L.1    Vintermyr, O.K.2    Liavaag, P.G.3    Jonsson, R.4    Johannessen, A.C.5
  • 41
    • 0031404285 scopus 로고    scopus 로고
    • Apoptosis, mitosis, PCNA and bcl-2 in normal, leukoplakic and malignant epithelia of the human oral cavity: Prospective, in vivo study
    • PII S096419559700033X
    • Birchall MA, Schock E, Harmon BV and Gobe G: Apoptosis, mitosis, PCNA and bcl-2 in normal, leukoplakic and malignant epithelia of the human oral cavity: prospective, in vivo study. Oral Oncol 33: 419-425, 1997. (Pubitemid 28126040)
    • (1997) Oral Oncology , vol.33 , Issue.6 , pp. 419-425
    • Birchall, M.A.1    Schock, E.2    Harmon, B.V.3    Gobe, G.4
  • 42
    • 0030565001 scopus 로고    scopus 로고
    • Expression of programmed cell death regulatory p53 and bcl-2 proteins in oral lesions
    • DOI 10.1016/0304-3835(96)04258-9
    • Ravi D, Nalinakumari KR, Rajaram RS, Nair MK and Pillai MR: Expression of programmed cell death regulatory p53 and bcl-2 proteins in oral lesions. Cancer Lett 105: 139-146, 1996. (Pubitemid 26252585)
    • (1996) Cancer Letters , vol.105 , Issue.2 , pp. 139-146
    • Ravi, D.1    Nalinakumari, K.R.2    Rajaram, R.S.3    Nair, M.K.4    Pillai, M.R.5
  • 43
    • 0035004253 scopus 로고    scopus 로고
    • Evaluation of p53 and Bcl-2 oncoprotein expression in precancerous lesions of the oral cavity
    • Sulkowska M, Famulski W, Chyczewski L and Sulkowski S: Evaluation of p53 and bcl-2 oncoprotein expression in precancerous lesions of the oral cavity. Neoplasma 48: 94-98, 2001. (Pubitemid 32428538)
    • (2001) Neoplasma , vol.48 , Issue.2 , pp. 94-98
    • Sulkowska, M.1    Famulski, W.2    Chyczewski, L.3    Sulkowski, S.4
  • 44
    • 0032407651 scopus 로고    scopus 로고
    • p53 mutations and p53, WAF-1, Bax and Bcl-2 expression in field cancerization of the head and neck
    • Lavieille JP, Gazzeri S, Riva C, Reyt E, Brambilla C and Brambilla E: p53 mutations and p53, Waf-1, Bax and Bcl-2 expression in field cancerization of the head and neck. Anticancer Res 18: 4741-4749, 1998. (Pubitemid 29042054)
    • (1998) Anticancer Research , vol.18 , Issue.6 B , pp. 4741-4749
    • Lavieille, J.-P.1    Gazzeri, S.2    Riva, C.3    Reyt, E.4    Brambilla, C.5    Brambilla, E.6
  • 45
    • 0032929149 scopus 로고    scopus 로고
    • Prognostic significance of clinical parameters and biological markers in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy
    • Homma A, Furuta Y, Oridate N, Nakano Y, Kohashi G, Yagi K, Nagahashi T, Fukuda S, Inoue K and Inuyama Y: Prognostic significance of clinical parameters and biological markers in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. Clin Cancer Res 5: 801-806, 1999. (Pubitemid 29180831)
    • (1999) Clinical Cancer Research , vol.5 , Issue.4 , pp. 801-806
    • Homma, A.1    Furuta, Y.2    Oridate, N.3    Nakano, Y.4    Kohashi, G.5    Yagi, K.6    Nagahashi, T.7    Fukuda, S.8    Inoue, K.9    Inuyama, Y.10
  • 46
    • 0028783268 scopus 로고
    • Predictive and prognostic markers in a series of patients with head and neck squamous cell invasive carcinoma treated with concurrent chemoradiation therapy
    • Gasparini G, Bevilacqua P, Bonoldi E, Testolin A, Galassi A, Verderio P, Boracchi P, Guglielmi RB and Pezzella F: Predictive and prognostic markers in a series of patients with head and neck squamous cell invasive carcinoma treated with concurrent chemoradiation therapy. Clin Cancer Res 1: 1375-1383, 1995.
    • (1995) Clin Cancer Res , vol.1 , pp. 1375-1383
    • Gasparini, G.1    Bevilacqua, P.2    Bonoldi, E.3    Testolin, A.4    Galassi, A.5    Verderio, P.6    Boracchi, P.7    Guglielmi, R.B.8    Pezzella, F.9
  • 47
    • 0033567933 scopus 로고    scopus 로고
    • The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue
    • DOI 10.1002/(SICI)1097-0142(19990915)86:6<913::
    • Xie X, Clausen OP, De Angelis P and Boysen M: The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue. Cancer 86: 913-920, 1999. (Pubitemid 29439843)
    • (1999) Cancer , vol.86 , Issue.6 , pp. 913-920
    • Xie, X.1    Clausen, O.P.F.2    De Angelis, P.3    Boysen, M.4
  • 49
    • 0029814844 scopus 로고    scopus 로고
    • BCL-2 expression correlates with favourable outcome in head and neck cancer treated by accelerated radiotherapy
    • Wilson GD, Grover R, Richman PI, Daley FM, Saunders MI and Dische S: Bcl-2 expression correlates with favourable outcome in head and neck cancer treated by accelerated radiotherapy. Anticancer Res 16: 2403-2408, 1996. (Pubitemid 26326270)
    • (1996) Anticancer Research , vol.16 , Issue.4 C , pp. 2403-2408
    • Wilson, G.D.1    Grover, R.2    Richman, P.I.3    Daley, F.M.4    Saunders, M.I.5    Dische, S.6
  • 50
    • 0032890023 scopus 로고    scopus 로고
    • Correlations of bcl-2 and p53 expression with the clinicopathological features in tongue squamous cell carcinomas
    • DOI 10.1016/S1368-8375(98)00055-4, PII S1368837598
    • Yao L, Iwai M and Furuta I: Correlations of bcl-2 and p53 expression with the clinicopathological features in tongue squamous cell carcinomas. Oral Oncol 35: 56-62, 1999. (Pubitemid 28546845)
    • (1999) Oral Oncology , vol.35 , Issue.1 , pp. 56-62
    • Yao, L.1    Iwai, M.2    Furuta, I.3


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