Immunohistochemical evaluation of bcl-2 oncoprotein in oral dysplasia and carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

Volumn 85, Issue 6, 1998, Pages 692-698

  Singh, Baldev B ^a   Chandler Jr , Francis W ^a   Whitaker, S Bryan ^a   Forbes Nelson, Anna E ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2;

ARTICLE; CHEMISTRY; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; MOUTH MUCOSA; MOUTH TUMOR; PATHOLOGY; PHYSIOLOGY; PRECANCER; PROTO ONCOGENE; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HUMANS; IMMUNOHISTOCHEMISTRY; MOUTH MUCOSA; MOUTH NEOPLASMS; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0032086887     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1079-2104(98)90037-3     Document Type: Article

References (55)

1. Bishop JM. Molecular themes in oncogenesis. Cell 1991;64:235-48.
2. Hunter, T. Cooperation between oncogenes. Cell 1991;64:249-70.
3. Weinberg RA. Tumor suppressor genes. Science 1991;254:1138-46.
4. Korsmeyer SJ. bcl-2 initiates a new category of oncogenes: regulator of cell death. Blood 1992;80:879-86.
5. Tsujimoto Y, Gorham J, Cossman J, Jaffe E, Croce C. The t(14;18) chromosome translocation involved in B-cell neoplasms results from mistakes in VDJ joining. Science 1985;229:1390-3.
6. McDonnell TJ, Korsmeyer SJ. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature 1991;349:254-6.
7. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-6.
8. Krajewski S, Taraka S, Takayama S, Schibler M, Ferton W, Reed JC. Investigations of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum and outer mitochondrial membranes. Cancer Res 1993;53:4701-14.
9. Vaux D, Cory S, Adams J. bcl-2 gene promotes hematopoietic cell survival and cooperates with C-myc to immortalize pre-B cells. Nature 1988;335:440-2.
10. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A 1991;88:6961-5.
11. Krajewski S, Chatten, J, Hanada M, Reed JC. Immunohistochemical analysis of the bcl-2 oncoprotein in human neuroblastomas. Lab Invest 1995;71:42-54.
12. Krajewski S, Bodrug S, Gascoyne R, Berean K, Krajewska M, Reed JC. Immunohistochemicalanalysis of mcl-1 and bcl-2 proteins in normal and neoplastic lymph nodes. Am J Pathol 1994;145:515-25.
13. Colombel M, Symmans F, Gil S, O'Toole KM, Chopin D, Benson M, et al. Detection of the apoptosis-suppressing oncoprotein bcl-2 in hormone-refractory human prostate cancers. Am J Pathol 1993;143:390-400.
14. Lipponen P, Pietiainen T, Kosma VM, Aaltomaa S, Eskelinen M, Syrjanen K. Apopotosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favorable prognosis. J Pathol 1995; 177:49-55.
15. Chan WK, Mole MM, Levison DA, Ball RL, Lu GL, Patel K, et al. Nuclear and cytoplasmic bcl-2 expression in endometrial hyperplasia and adenocarcinoma. J Pathol 1995;177:241-6.
16. Tron VA, Krajewski S, Klein-Parker H, Li G, Ho VC, Reed JC, et al. Immunohistochemical analysis of bcl-2 protein regulation in cutaneous melanoma. Am J Pathol 1995;146:643-50.
17. Bronner M, Culin C, Reed JC, Furth EE. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 1994;146:20-6.
18. Mosnier JF, Perret AG, Brunon J, Bousheron S. Expression of the bcl-2 oncoprotein in meningiomas. Am J Clin Pathol 1996;106:652-9.
19. Lipponen PK, Aaltomaa S, Eskelinen M. Expression of apopotosis suppressing bcl-2 protein in transitional cell tumours. Histopathology 1996;28:135-40.
20. Pezzella F, Turley H, Kuzu I, Tunkegar MF, Dunnil MS, Pierce CB, et al. bcl-2 protein in non-small-cell lung carcinoma. N Engl J Med 1993;329:690-4.
21. Ben-Ezra JM, Kornstein MJ, Grimes MM, Krystal G. Small cell carcinomas of the lung express the bcl-2 protein. Am J Pathol 1994;145:1036-40.
22. Gaffney EF, O'Neill AJ, Staunton MJ. bcl-2 and prognosis in non-small-cell lung carcinoma. N Engl J Med 1994;330:1757-8.
23. Ritter JH, Dresler CM, Wick MR. Expression of bcl-2 protein in stage T1 NOMO non-small cell lung carcinoma. Hum Pathol 1995;26:1227-32.
24. Nakagawa K, Yamamura K, Maeda S, Ichihashi M. bcl-2 expression in epidermal keratinocytic diseases. Cancer 1994;74: 1720-4.
25. Saegusa M, Takano Y, Hashimura M, Shoji Y, Okaysu I. The possible role of bcl-2 expression in the progression of tumors of the uterine cervix. Cancer 1995;76:2297-303.
26. Wrone-Smith T, Johnson T, Nelson B, Boise LH, Thompson CB, Nunez G, et al. Discordant expression of bcl-x and bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo. Am J Pathol 1995;146:1079-88.
27. Lu QL, Elia G, Lucas S, Thoma JA. bcl-2 proto-oncogene expression in Epstein-Barr-virus-associated nasopharyngeal carcinoma. Int J Cancer 1993;53:29-35.
28. Gallo O, Bianchi S, Porfiro B. bcl-2 overexpression and smoking history in head and neck cancer. J Natl Cancer Inst 1995;87:1024.
29. Jordan RCK, Catzavelos GC, Barrett AW, Speight PN. Differential expression of bcl-2 and bax in squamous cell carcinomas of the oral cavity. Eur J Cancer B Oral Oncol 1996;32B:394-400.
30. Ohbu M, Saegusa M, Kobayashi N, Tsukamoto H, Mieno H, Kakita A, et al. Expression of bcl-2 protein in esophageal squamous cell carcinomas and its association with lymph node metastasis. Cancer 1997;79:1287-93.
31. Shafer WG. Oral carcinoma in situ. Oral Surg Oral Med Oral Pathol 1975;39:227-37.
32. WHO Collaborating Center for Oral Precancerous Lesions. Definition of leukoplakia and related conditions. Oral Surg Oral Med Oral Pathol 1978;46:518-39.
33. Bouquot JE, Gnepp DR. Epidemiology of carcinoma in situ of the upper aerodigestive tract. Cancer 1988;61:1685-90.
34. Cattoretti G, Suurmeijer AJH. Antigen unmasking on formalin-fixed paraffin-embedded tissue using microwave: a review. Advances in Anatomy and Pathology 1995;2:2-9.
35. Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79:321-30.
36. Bouquot JE, Weiland LH, Kurland LT. Leukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935-1984. Oral Surg Oral Med Oral Pathol 1988;65:199-207.
37. Atula S, Kurvinen K, Grenmen R, Syrjanen S. SSCP pattern indicative for p53 mutation is related to advanced stage and high grade of tongue cancer. Eur J Cancer B Oral Oncol 1996;32B:222-9.
38. Nakanishi Y, Noguchi M, Matsumo Y, Saikawa M, Mukai K, Shimosato Y, et al. p53 expression in squamous cell carcinoma and surrounding epithelium of the upper aerodigestive tract. Cancer 1995;75:1657-62.
39. Shin DM, Vorabud N, Ro Y, Lee JS, Hong WK, Hittelman WN, et al. Sequential increase in proliferating cell nuclear antigen in head and neck tumorigenesis: a potential biomarker. J Natl Cancer Inst 1993;85:970-8.
40. Symonds H, Krall L, Remington L, Saenz-Robles M, Jacks T, Van Dyke T, et al. p53 dependent apoptosis in vivo: impact of p53 inactivation on tumorigenesis. Cold Spring Harb Symp Quant Biol 1994;LIX:247-57
41. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994;9:1799-05.
42. Ngan B-Y, Chen-Levy Z, Weiss LM, Warnke RA, Cleary ML. Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) translocation. N Engl J Med 1988;318:1638-44.
43. Pezzella F, Harett J. bcl-2 protein expression in follicular lymphomas in absence of 14;18 translocation. Lancet 1990;336: 1510-1.
44. Zutter M, Hockenbery D, Silverman GA, Korsmeyer SJ. Immuno-localization of the bcl-2 protein within hematopoietic neoplasms. Blood 1991;78:1062-8.
45. Strasser A, Harris AW, Bath ML, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990;348:331-3.
46. Brackman DG. Molecular biology of head and neck cancer. Semin Oncol 1994;21:320-9.
47. Lu QL, Abel P, Foster CS, Lalani E. bcl-2: role in epithelial differentiation and oncogenesis. Human Pathol 1996;27:102-10.
48. Saegusa M, Okayasn I. Down-regulation of bcl-2 expression is closely related to squamous differentiation and progesterone therapy in endometrial carcinomas. J Pathol 1997; 182:929-36.
49. x protein in primary breast cancer is associated with high tumor grade and tumor metastasis. The Cancer Journal 1997;3:230-7.
50. O'Guin WM, Schermer A, Lynch M, Sun TT. Differentiation-specific expression of keratin pairs. In: Goldman RD, Steinert PM, editors. Cellular and molecular biology of intermediate filaments. New York: Plenum Press; 1990. p. 301-34.
51. Malecha MJ, Miettinen MJ. Expression of keratin 13 in human epithelial neoplasm. Virchows Archiv A Pathol Anat 1991; 418:249-54.
52. Krajewski S, Bodrug S, Krajewska M, Shabik A, Gascoyne R, Berean K, et al. Immunohistochemical analysis of mcl-1 protein in human tissues: differential regulation of mcl-1 and bcl-2 protein production suggests a unique role for mcl-1 in control of programmed cell death in vivo. Am J Pathol 1995;146:1309-19.
53. Yang T, Kozopus KM, Craig RW. The intracelluar distribution and pattern of expression of mcL-1 overlap with but not identical to those of bcl-2. J Cell Biol 1995;128:1173-94.
54. Kim J, Yook JI. Immunohistochemical study on proliferating cell nuclear antigen expression in ameloblastomas. Eur J Cancer B Oral Oncol 1994;30B,2:126-31.
55. Todd R, Donoff RB, Wong TW. The molecular biology of oral carcinogensis: toward a tumor progression model. J Oral Maxillofac Surg 1997;57:613-23.