Apoptosis, mitosis, PCNA and bcl-2 in normal, leukoplakic and malignant epithelia of the human oral cavity: Prospective, in vivo study

Oral Oncology

Volumn 33, Issue 6, 1997, Pages 419-425

  Birchall, M A ^a,d   Schock, E ^b   Harmon, B V ^c   Gobe G ^b  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^d SOUTHMEAD HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Bcl 2; Carcinoma; Dysplasia; Hyperplasia; Mitosis; PCNA

Indexed keywords

CYCLINE; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CANCER INVASION; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPLASIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA; MALE; MITOSIS; MOUTH CANCER; PRIORITY JOURNAL; PROSPECTIVE STUDY;

EID: 0031404285     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0964-1955(97)00033-X     Document Type: Article

References (27)

1. Birchall, M. A., Winterford, C. M., Gobé, G. and Harmon, B. V., Apoptosis and mitosis in oral and oropharyngeal epithelium; evidence for a topographical switch in premalignant lesion. Cell Proliferation, 1996, 29, 447-456.
2. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D. and Korsmeyer, S. J., Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature, 1990, 348, 334-336.
3. Jacobson, M. D., Burne, J. F. and Raff, M. C., Mechanisms of programmed cell death and Bcl-2 protection. Biochemical Society Transactions, 1994, 22, 600-602.
4. Tsujimoto, Y. and Croce, C., Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proceedings of the National Academy of Sciences USA, 1986, 83, 5214-5218.
5. Watson, A. J. M., Merrit, A. J., Jones, L. S., et al., Evidence for reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas. British Journal of Cancer, 1996, 74, 889-895.
6. Lu, Q. L., Elia, G., Lucas, S. and Thomas, J. A., Bcl-2 protooncogene expression in Epstein-Barr associated nasopharyngeal carcinoma. International Journal of Cancer, 1993, 53, 29-35.
7. Birchall, M. A., Winterford, C. M., Allan, D. J. and Harmon, B. V., Apoptosis in normal epithelium, premalignant and malignant lesions of the oropharynx and oral cavity: a preliminary study. Oral Oncology, European Journal of Cancer, 1995, 31B, 380-383.
8. Bravo, R., Frank, R., Blundell, P. A. and McDonald-Bravo, H., Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature, 1987, 326, 515-520.
9. Hall, P. A., Levison, D. A., Woods, A. L., et al., Proliferating cell nuclear antigen (PCNA) immunolocalisation in paraffin sections: an index of cellular proliferation with evidence of deregulated expression in some neoplasms. Journal of Pathology, 1990, 162, 285-294.
10. Shivji, M. K. K., Kenny, M. K. and Wood, R. D., Proliferating cell nuclear antigen (PCNA) is required for DNA excision repair. Cell, 1992, 69, 657-676.
11. Hall, P. A., Coates, P. J., Goodlad, R. A., Hart, I. R. and Lane, D. P., Proliferating cell nuclear antigen expression in non-cycling cells may be induced by growth factors in vivo. British Journal of Cancer, 1994, 70, 244-247.
12. Steinbeck, R. G., Moege, J., Heselmeyer, K. M., et al., DNA content and PCNA immunoreactivity in oral precancerous and cancerous lesions. Oral Oncology, European Journal of Cancer, 1994, 29B, 279-284.
13. Field, J. K., Spandidos, D. A., Malliri, A., et al., Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of head and neck. British Journal of Cancer, 1991, 45, 450-456.
14. Grasl-Knapp, B., Ruttkay-Nedecky, B., Kovdeska, H., Bukowska, K., Bursch, W. and Schulte-Hermann, R., In situ detection of fragmented DNA (TUNEL) assay fails to discriminate among apoptosis, necrosis and autolytic cell death: a cautionary note. Hepatology, 1995, 21, 1465-1468.
15. Altman, D. G., Practical Statistics for Medical Research. Chapman & Hall, London, 1991.
16. Li, Y. Q., Fan, C. Y., O'Connor, P. J., Winton, D. J. and Potten, C. S., Target cells for the cytotoxic effects of carcinogens in the murine small bowel. Carcinogenesis, 1992, 13, 361-368.
17. Michaels, L., ENT Histopathology. Springer Verlag, London, 1987.
18. Silverman, S., Gorsky, M. and Lozada, F., Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer, 1984, 53, 563-568.
19. Maran, A. G. D., Nature of head and neck cancer. In Stell and Maran's Head and Neck Surgery, eds A. G. D. Maran, M. Gaze and J. A. Wilson. Butterworth-Heinemann, Oxford, 1993.
20. McCormick, D. and Hall, P. A., The complexities of proliferating cell antigen. Histopathology, 1992, 21, 591-594.
21. Polakowska, R. R. and Haake, A. R., Apoptosis: the skin from a new perspective. Death and Differentiation, 1994, 1, 19-31.
22. Scott, R. J., Hall, P. A. and Hladane, J. S., A comparison of immunohistochemical markers of cell proliferating with experimentally determined growth fraction. Journal of Pathology, 1991, 87, 173-178.
23. Ravi, D., Nalinakumari, K. R., Rajaram, R. S., Nair, M. K. and Pillai, M. R., Expression of programmed cell death regulatory p53 and bcl-2 proteins in oral lesions. Cancer Letters, 1996, 105, 139-146.
24. Dawson, C. W., Eliopoulos, A. G., Dawson, J. and Young, L. S., BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation. Oncogene, 1995, 10, 69-77.
25. Jordan, R. C. K., Catzavelos, G. C., Barrett, A. W. and Speight, P. M., Differential expression of bcl-2 and bax in squamous cell carcinoma of the oral cavity. Oral Oncology, European Journal of Cancer, 1996, 32B, 394-400.
26. Farrow, S. N. and Brown, R., New members of the bcl-2 family and their protein partners. Current Opinion in Genetics and Development, 1996, 6, 45-49.
27. Jones, A. S., Morar, P., Phillips, D. E., Field, J. K., Husband, D. and Helliwell, T. R., Second primary tumours in patients with head and neck squamous cell carcinoma. Cancer, 1995, 75, 1343-1353.