Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro

Journal of Oral Pathology and Medicine

Volumn 27, Issue 1, 1998, Pages 11-17

  Harada, Hidemitsu ^a   Mitsuyasu, Takeshi ^a   Seta, Yuji ^a   Maruoka, Yuka ^a   Toyoshima, Kuniaki ^a   Yasumoto, Shigeru ^b  

^a KYUSHU DENTAL COLLEGE   (Japan)

^b KANAGAWA CANCER CENTER   (Japan)

Author keywords

Apoptosis; Bcl 2; Keratinocytes; Oral; Terminal differentiation

Indexed keywords

EID: 0031964689     PISSN: 09042512     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0714.1998.tb02084.x     Document Type: Article

References (24)

1. LEBRUN DP, WARNKERA, CLEARY ML. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 1993; 142: 743-53.
2. y-antigen expression is involved in an early event of a cell's commitment to apoptosis. Histochemistry 1995; 103: 339-43.
3. SEED, JC. Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994; 124: 1-6.
4. WILLIAMS GT, SMITH CA. Molecular regulation of apoptosis: genetic controls on cell death. Cell 1993; 74: 777-9.
5. HOCKENBERY DM, ZUTTER M, HICKEY W, NAHM M, KORSMEYER SJ. Bcl2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991; 88: 6961-5.
6. VEIS DJ, SORENSON CM, SHUTTER JR, KORSMEYER SJ. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidney and hypopigmented hair. Cell 1993; 75: 229-40.
7. POLAKOWSKA RR, PIACENTINI M, BARTLETT R, GOLDSMITH LA, HAAKE AR. Apoptosis in human skin development: morphogenesis, periderm, and stem cells. Dev Dyn 1994; 199: 176-88.
8. JORDAN RCK, CATZAVELOS GC, BARRET AW, SPEIGHT PM. Differential expression of bcl-2 and bax in squamous cell carcinoma of the oral cavity. Eur J Cancer B Oral Oncol 1996; 32B: 394-400.
9. WRONE-SMITH T, JOHNSON T, NELSON B, et al Discordant expression of Bcl-X and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo. Am J Pathol 1995; 146: 1079-88.
10. NAKAGAWA K, YAMAMURA K, MAEDA S, ICHIHASHI M. Bcl-2 expression in epidermal keratinocytic disease. Cancer 1994; 74: 1720-4.
11. GAVRIELI Y, SHERMAN Y, BEN-SASSON SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
12. HARADA H, OSAKI Y, KUKITA T, TASHIRO H, YASUMOTO S. Monoclonal antibody G6K12 specific for membrane-associated differentiation marker of human stratified squamous epithelia and squamous cell carcinoma. J Oral Pathol Med 1993; 32: 145-52.
13. COTSARELIS G, CHENG S-Z, DONG G, SUN T-T, LAVKER RM. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 1989; 57: 201-9.
14. WRIGHT NA, ALISON M. The biology of epithelial cell populations. 1 and 2. Oxford: Clarendon Press, 1984.
15. MICHEL M, TOROK N, GODBOUT MJ, et al. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage. J Cell Sci 1996; 109: 1017-28.
16. LOVAS JGL. Apoptosis in human epidermis: a post-mortem study by light and electron microscopy. Aust J Dermatol 1986; 27: 1-5.
17. YOSHIOKA C, MURAKI Y, FUKUDA J, HANEJI T, KOBAYASHI N. Identification of the Fas antigen in human girtgiva. J Dent Res 1996; 6: 1353-7.
18. MURAKI Y, YOSHIOKA C, FUKUDA J, HANEJI T, KOBAYASHI N. Immunohistochemical detection of Fas antigen in oral epitheha. J Oral Pathol Med 1997; 26: 57-62.
19. MITRA RS, WRONE-SMITH T, SIMONIAN P, FOREMAN KE, NUNEZ G, NICKOLOFF BJ. Apoptosis in keratinocytes is not dependent on induction of differentiation. Lab Invest 1997; 76: 99-107.
20. RHEINWALD JG, BECKETT MA. Defective terminal differentiation in culture as a consistent and selectable character of malignant human keratinocytes. Cell 1980; 22: 629-32.
21. RHEINWALD JG, BECKETT MA. Tumorigenic keratinocyte lines requiring anchorage and selectable character of malignant human squamous cell carcinomas. Cancer Res 1981; 41: 629-32.
22. MARTHINUSS J, LAWRENCE L, SEIBERG M. Apoptosis in Pam 212, an epidermal keratinocyte cell line: a possible role for bcl-2 in epidermal differentiation. Cell Growth Differ 1995; 6: 239-50.
23. PIETENPOL JA, PAPADOPOULOS N, MARKOWITZ S, WILLSON JKV, KINZLER KW, VOGELSTEIN B. Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer Res 1994; 54: 3714-7.
24. MITSUYASU T, HARADA H, HIGUCHI Y, et al. Immunohistochemical demonstration of bcl-2 protein in ameloblastomas. J Oral Pathol Med; in press.