Deficiency in sPLA2 does not affect HDL levels or atherosclerosis in mice

Biochemical and Biophysical Research Communications

Volumn 294, Issue 1, 2002, Pages 88-94

  Burton, Charlotte A ^a   Patel, Sushma ^a   Mundt, Steven ^a   Hassing, Heide ^a   Zhang, Donghui ^a   Hermanowski Vosatka, Anne ^a   Wright, Samuel D ^a   Chao, Yu Sheng ^a   Detmers, Patricia A ^a   Sparrow, Carl P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aortic lesion; ApoE; Cholesterol; Phospholipids; sPLA2

Indexed keywords

HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPASE A2; PHOSPHOLIPID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; ENZYME DEFICIENCY; FAST PROTEIN LIQUID CHROMATOGRAPHY; FEMALE; GENOTYPE; HISTOPATHOLOGY; HUMAN; LIPID DIET; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL;

ANIMALS; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY FATS; FEMALE; GENOTYPE; LIPIDS; LIPOPROTEINS, HDL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOLIPASES A; SEX FACTORS;

EID: 18444415139     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00441-2     Document Type: Article

References (53)

1. 2
2. 2
3. 2 mRNA synthesis is stimulated by two distinct mechanisms in rat vascular smooth muscle cells
4. Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate
5. 2 gene in the tissues of endotoxin shock rats and its suppression by glucocorticoid
6. 2 expression and inflammation: The relationship with associated disease states
7. Atherosclerosis an inflammatory disease
8. 2
9. 2 in human atherosclerotic plaques
10. 2 in normal and atherosclerotic arteries. Activity of the isolated enzyme on low-density lipoproteins
11. 2 isoforms in human normal and atherosclerotic arterial wall
12. 2 expression in human aortic tissue in dependence on the degree of atherosclerosis
13. 2
14. 2 gene in inbred mouse strains
15. 2 research
16. Diet-induced Atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption
17. Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering
18. 2 in septic shock
19. 2 assay modified for serum analysis
20. Effects of levorphanol on phospholipid metabolism and composition in Escherichia coli
21. Inhibition of RNA synthesis in Escherichia coli by levorphanol
22. Phospholipases and phospholipid turnover in Escherichia coli spheroplasts
23. Microdetermination of long-chain fatty acids in plasma and tissues
24. A relation between non-esterified fatty acids in plasma and the metabolism of glucose
25. 2
26. Infectious agents are not necessary for murine atherogenesis
27. Deficiency in inducible nitric oxide synthase results in reduced Atherosclerosis in apolipoprotein E-deficient mice
28. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100
29. Nifedipine reduces atherogenesis in cholesterol-fed heterozygous WHHL rabbits
30. Dissociation of atherogenesis from aortic accumulation of lipid hydroperoxides in Watanabe heritable hyperlipidemic rabbits
31. The antioxidant butylated hydroxytoluene protects against atherosclerosis
32. Dehy-droepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbit
33. Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol
34. Antiatherosclerotic effects of nicardipine and nifedipine in cholesterol-fed rabbits
35. Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N, N-9-diphenyl-phenylenediamine
36. Macrophage colony stimulating factor prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits
37. Anti-atherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit
38. Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall
39. Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice
40. In vivo uptake of radiolabeled MDA2 an oxidation-specific monoclonal antibody provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression
41. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
42. 17β-Estradiol prevents fatty streak formation in apolipoprotein E-deficient mice
43. C-reactive protein a sensitive marker of inflammation predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg cohort study 1984 to 1992
44. 2 as an independent predictor of coronary heart disease
45. 2 predict coronary events in patients with coronary artery disease
46. C-reactive protein in healthy subjects: Associations with obesity insulin resistance and endothelial dysfunction A potential role for cytokines originating from adipose tissue
47. Genetic edidence for a common pathway mediating oxidative stress inflammatory gene induction and aortic fatty streak formation in mice
48. Increased prebeta-high density lipoprotein apolipoprotein AI and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes
49. Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses
50. Expression of the human apolipoprotein A-I gene in transgenic mice alters high density lipoprotein (HDL) particle size distribution and diminishes selective uptake of HDL cholesteryl esters
51. Hepatic lipase deficiency clinical biochemical and molecular genetic characteristics
52. Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene
53. Mouse preheparin plasma contains high levels of hepatic lipase with low affinity for heparin