N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth

Oncogene

Volumn 21, Issue 22, 2002, Pages 3552-3561

  Hatzi, Elissavet ^a   Murphy, Carol ^a,b   Zoephel, Andreas ^c   Rasmussen, Heidi ^d   Morbidelli, Lucia ^e   Ahorn, Horst ^c   Kunisada, Keita ^f   Tontsch, Ulrike ^c   Klenk, Michael ^g   Yamauchi Takihara, Keiko ^f   Ziche, Marina ^e   Schweigerer, Lothar ^g   Fotsis, Theodore ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b Ioannina Biomedical Research Institute   (Greece)

^c BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF SIENA   (Italy)

^f OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Endothelial cell; IL 6; N myc; Neuroblastoma; STAT3

Indexed keywords

INTERLEUKIN 6; STAT3 PROTEIN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; ENDOTHELIUM CELL; GENE AMPLIFICATION; GENE OVEREXPRESSION; GROWTH INHIBITION; NEOVASCULARIZATION (PATHOLOGY); NEUROBLASTOMA; NONHUMAN; ONCOGENE C MYB; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL DIVISION; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM NEOPLASMS; CORNEA; DNA-BINDING PROTEINS; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; INTERLEUKIN-6; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; NEUROBLASTOMA; ONCOGENE PROTEIN P55(V-MYC); RABBITS; RNA, NEOPLASM; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 18444413981     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205440     Document Type: Article

References (40)