Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 6, 2002, Pages 2725-2733

  Ezzat, S ^a   Fear, S ^b   Gaillard, R C ^c   Gayle, C ^d   Landy, H ^e   Marcovitz, S ^f   Mattioni, T ^g   Nussey, S ^b   Rees, A ^a   Svanberg, E ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b Serono International SA   (Switzerland)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e MONTREAL GENERAL HOSPITAL   (Canada)

^f ST GEORGE S HOSPITAL   (United Kingdom)

^g UNIVERSITY OF WALES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; PLACEBO;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BLOOD VOLUME; BODY COMPOSITION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DRUG SAFETY; ECHOCARDIOGRAPHY; FEMALE; FLUID BALANCE; GENDER; GROWTH HORMONE DEFICIENCY; HEART FUNCTION; HEART LEFT VENTRICLE CONTRACTION; HORMONE SUBSTITUTION; HUMAN; IMPEDANCE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MITRAL VALVE; MULTICENTER STUDY; PHYSICAL DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAXATION TIME; STRUCTURE ACTIVITY RELATION; SYSTOLIC BLOOD PRESSURE;

EID: 18444382664     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.87.6.8542     Document Type: Article

References (48)

1. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency
2. Beneficial effects of growth hormone treatment in GH-deficient adults
3. Growth hormone treatment of adults with growth hormone deficiency: Results of a 13-month placebo controlled cross-over study
4. Growth hormone deficiency in adulthood and the effects of growth hormone replacement therapy: A review
5. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency
6. Premature mortality due to cardiovascular disease in hypopituitarism
7. The effect of hypopituitarism on life expectancy
8. Increased cerebrovascular mortality in patients with hypopituitarism
9. High incidence of cardiovascular disease and increased prevalence of cardiovascular risk factors in women with hypopituitarism not receiving growth hormone treatment: Preliminary results
10. The impact of pituitary adenoma on mortality. Increased sick leave and disability retirement in a cross-sectional analysis of Swedish national data
11. Treatment of growth hormone deficiency in adults
12. Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults
13. Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults
14. Decrease in carotid intima-media thickness after 1 year growth hormone (GH) treatment in adults with GH deficiency
15. Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study
16. Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency
17. Myocardial dysfunction in treated adult hypopituitarism: A possible explanation for increased cardiovascular mortality
18. Growth hormone and heart performance. A novel mechanism of cardiac wall stress regulation in humans
19. Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency
20. Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: Assessment with radionuclide angiography
21. Adults with childhood-onset growth hormone deficiency: Effects of growth hormone treatment on cardiac structure
22. Long term cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients
23. Cardiovascular and renal effects of growth hormone
24. Short and long-term cardiovascular effects of growth hormone therapy in growth hormone deficient adults
25. Cardiovascular effects of growth hormone treatment in growth hormone deficient adults: Stimulation of the renin-aldosterone system
26. Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood
27. The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiographic measurements
28. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method
29. Insulin-like growth factors (IGF) I and II and IGF binding proteins 1, 2 and 3 during low-dose growth hormone (GH) infusion and sequential euglycemic and hypoglycemic glucose clamps: Studies in GH-deficient patients
30. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment
31. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial
32. Two years of replacement therapy in adults with growth hormone deficiency
33. Whole body and regional soft tissue changes in growth hormone deficient adults after on year of growth hormone treatment: A double-blind, randomized, placebo-controlled study
34. Treatment of adults with growth hormone deficiency with recombinant human GH
35. Replacement treatment with biosynthetic human growth hormone in growth hormone-deficient hypopituitary adults
36. The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients
37. Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency
38. The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index and gender
39. Growth hormone (GH)-deficient men are more responsive to GH treatment than women
40. Body composition, bone metabolism, and heart structure and function in growth hormone-deficient adults before and after GH replacement therapy at low doses
41. Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study
42. A practical guide to assessment of ventricular diastolic function using Doppler echocardiography
43. GH replacement in 1034 growth hormone deficient hypopituitary adults: Demographic and clinical characteristics, dosing and safety
44. Defects of insulin action and skeletal muscle glucose metabolism in growth hormone-deficient adults persist after 24 months of recombinant human growth hormone therapy
45. The effect of the deterioration of insulin sensitivity on β-cell function in growth-hormone-deficient adults following 4-month growth hormone replacement therapy
46. Insulin secretion in growth hormone-deficient adults: Effects of 24 months' therapy and five days' acute withdrawal of recombinant human growth hormone
47. Effects of 7 years of growth hormone replacement therapy in hypopituitary adults