Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study

Clinical Endocrinology

Volumn 52, Issue 4, 2000, Pages 447-455

  Colao, Annamaria ^a,b   Cuocolo, Alberto ^b,c   Di Somma, Carolina ^a   Cerbone, Gaetana ^a   Della Morte, Anna Maria ^b   Pivonello, Rosario ^a   Nicolai, Emanuele ^b   Salvatore, Marco ^b   Lombardi, Gaetano ^a  

^a Dept of Biomorphological/Funct S ^*  (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DISEASE DURATION; ELECTROCARDIOGRAM; EXERCISE; FEMALE; GROUPS BY AGE; GROWTH HORMONE DEFICIENCY; HEART DEVELOPMENT; HEART LEFT VENTRICLE EJECTION FRACTION; HEART PERFORMANCE; HEART RATE; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; REST; SCINTIANGIOGRAPHY;

ADULT; AGE OF ONSET; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; GATED BLOOD-POOL IMAGING; GROWTH HORMONE; HEART; HEART DISEASES; HEART RATE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED;

EID: 0034059268     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2000.00972.x     Document Type: Article

References (49)

1. Aimaretti, G., Corneli, G., Razzore, P., Bellone, S., Baffoni, C., Arvat, E., Camanni, F. & Ghigo, E. (1998) Comparison between insulin-induced hypoglycemia and growth hormone (GH) -releasing hormone + arginine as provocative tests for the diagnosis of GH deficiency in adults. Journal of Clinical Endocrinology and Metabolism, 83, 1615-1618.
2. Amato, G., Carella, C., Fazio, S., La Montagna, G., Cittadini, A., Sabatini, D., Marciano-Mone, C., Saccà, L. & Bellastella, A. (1993) Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. Journal of Clinical Endocrinology and Metabolism, 77, 1671-1676.
3. Bacharach, S.L., Green, M.V., Borer, J.S., Hyde, J.E., Farkas, S.P. & Johnston, G.S. (1979) Left ventricular peak ejection rate, filling rate and ejection fraction: frame requirements at rest and exercise. Journal of Nuclear Medicine, 20, 1889-1893.
4. Bates, A.S., Vant'Hoff, W., Jones, P.J. & Clayton, R.N. (1996) The effect of hypopituitary on life expectancy. Journal of Clinical Endocrinology and Metabolism, 81, 1169-1172.
5. Bengtsson, B., Edén, S., Lonn, L., Kvist, H., Stokland, A., Lindstedt, G., Bosaeus, I., Tolli, J., Sjostrom, L. & Isaksson, O.G. (1993) Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. Journal of Clinical Endocrinology and Metabolism, 76, 309-317.
6. Bengtsson, B.A., Christiansen, J.S., Cuneo, R.C. & Saccà, L. (1997) Cardiovascular effects of GH. Journal of Endocrinology, 152, 1-3.
7. Böger, R.H., Skamira, C., Bode-Böger, S.M., Brabant, C., Von Zur Muhlen, A. & Frolich, J.C. (1996) Nitric oxide mediates the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. Journal of Clinical Investigation, 98, 2706-2713.
8. Bonow, R.O., Bacharach, S.L., Green, M.V., Kent, K.M., Rosing, D.R., Lipson, L.C., Leon, M.B. & Epstein, S.E. (1981) Impaired left ventricular diastolic filling in patients with coronary artery disease: assessment with radionuclide angiography. Circulation, 64, 315-323.
9. Bonow, R.O., Vitale, D.F., Bacharach, S.L., Frederick, T.M., Kent, K.M. & Green, M.V. (1985) Asynchronous left ventricular regional function and impaired global diastolic filling in patients with coronary artery disease: reversal after coronary angioplasty. Circulation, 71, 297-307.
10. Bonow, R.O., Vitale, D.F., Bacharach, S.L., Maron, B.J. & Green, M.V. (1988) Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects. Journal of American College of Cardiology, 11, 50-58.
11. Borson-Chazot, F., Serusclat, A., Kalfallah, Y., Ducottet, X., Sassolas, G., Bernard, S., Labrousse, F., Pastene, J., Sassolas, A., Roux, Y. & Berthezéne, F. (1999) Decrease in carotid intima-media thickness after 1 year growth hormone (GH) treatment in adults with GH deficiency. Journal of Clinical Endocrinology and Metabolism, 84, 1329-1333.
12. Bülow, B., Hagmar, L., Mikoczy, Z., Nordström, C.H. & Erfurth, E.M. (1997) Increased cerebrovascular mortality in patients with hypopituitarism. Clinical Endocrinology, 46, 75-81.
13. Carrol, P.V. & Christ, E.R. (1998) Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Journal of Clinical Endocrinology and Metabolism, 83, 382-395.
14. Christiansen, J.S., Jorgensen, J.O.L. & Theusen, L. (1996) Cardiovascular aspects of growth hormone replacement therapy in adults. Endocrinology and Metabolism, 3A, 19-22.
15. Cittadini, A., Cuocolo, A., Merola, B., Fazio, S., Sabatini, D., Nicolai, E., Colao, A., Longobardi, S., Lombardi, G. & Saccà, L. (1994) Impaired cardiac performance in GH-deficient adults and its improvement after GH replacement. American Journal of Physiology, 267, E219-E225.
16. Colao, A., Cerbone, G., Pivonello, R., Klain, M., Aimaretti, G., Faggiano, A., Di Somma, C., Salvatore, M. & Lombardi, G. (1998a) Growth hormone deficiency in elderly patients with hypothalamo-pituitary tumors. Pituitary, 1, 59-67.
17. Colao, A. & Lombardi, G. (1998b) GH and PRL excess. Lancet, 352, 1455-1461.
18. Colao, A., Cuocolo, A., Di Somma, C., Cerbone, G., Della Morte, A.M., Nicolai, E., Lucci, R., Salvatore, M. & Lombardi, G. (1999a) Impaired cardiac performance in elderly patients with growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 85, 3950-3955.
19. Colao, A., Cerbone, G., Pivonello, R., Aimaretti, G., Loche, S., Di Somma, C., Faggiano, A., Corneli, G., Ghigo, E. & Lombardi, G. (1999b) The Growth Hormone (GH) response to arginine plus GH releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency. Journal of Clinical Endocrinology and Metabolism, 84, 1277-1282.
20. Colao, A., Di Somma, C., Pivonello, R., Loche, S., Aimaretti, G., Cerbone, G., Faggiano, A., Corneli, G., Ghigo, E. & Lombardi, G. (1999c) Bone loss is correlated to the severity of growth hormone (GH) deficiency in adult patients with hypopituitarism. Journal of Clinical Endocrinology and Metabolism, 84, 1919-1924.
21. Cuocolo, A., Nicolai, E., Colao, A., Longobardi, S., Cardei, S., Fazio, S., Merola, B., Lombardi, G., Saccà, L. & Salvatore, M. (1996) Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: assessment with radionuclide angiography. European Journal of Nuclear Medicine, 23, 390-394.
22. De Boer, H., Blok, G. & van der Veen, E.A. (1995) Clinical aspects of growth hormone deficiency in adults. Endocrine Review, 16, 63-86.
23. Feigenbaum, H. (1979) Echocardiography. 2nd edn. Lea and Febiger, Philadelphia.
24. Fort, S., Weaver, J.U., Monson, J.P. & Mills, P.G. (1995) The effects of low dose recombinant human growth hormone on cardiovascular structure and function in hypopituitary growth hormone-deficient adults. Endocrinology and Metabolism, 2, 119-126.
25. Growth Hormone Research Society (GRS). (1998) Consensus guidelines for diagnosis and treatment of adults with GH deficiency. Journal of Clinical Endocrinology and Metabolism, 83, 379-381.
26. Guse, A.H., Kiess, W., Funk, B., Kessler, U., Berg, I. & Gercken, G. (1992) Identification and characterization of insulin-like growth factor receptors on adult rat myocytes: linkage to inositol-1,4,5-trisphosphate formation. Endocrinology, 130, 145-151.
27. Hanson, M.C., Kenneth, A.F., Alexander, R.W. & DeLafontaine, P. (1993) Induction of cardiac insulin-like growth factor-I gene expression in pressure overload hypertrophy. American Journal of Medical Science, 306, 69-74.
28. Isgaard, J., Nilsson, A., Vickman, K. & Isaksson, O.G.P. (1989) Growth hormone regulates the level of insulin-like growth factor-I mRNA in rats skeletal muscle. Journal of Endocrinology, 120, 107-112.
29. Ito, H., Hiroe, M., Hirata, Y., Tsujino, M., Aduchi, S., Shichiri, M., Koike, A., Nogami, A. & Marumo, F. (1993) Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes. Circulation, 87, 1715-1721.
30. Lombardi, G., Colao, A., Cuocolo, A., Longobardi, S., Di Somma, C., Orio, F., Merola, B., Nicolai, E. & Salvatore, M. (1997a) Cardiological aspects of growth hormone and insulin-like growth factor-1. Journal of Pediatric Endocrinology and Metabolism, 10, 553-560.
31. Lombardi, G., Colao, A., Marzullo, P., Ferone, D., Longobardi, S., Esposito, V. & Merola, B. (1997b) Is growth hormone bad for your heart: Cardiovascular impact of GH deficiency and excess. Journal of Endocrinology, 155, S33-S37.
32. Longobardi, S., Cuocolo, A., Merola, B., Di Rella, F., Colao, A., Nicolai, E., Cardei, S., Salvatore, M. & Lombardi, G. (1998) Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency. Clinical Endocrinology, 48, 137-143.
33. Mayoux, E., Ventura-Clapier, R., Timsit, J., Behar-Cohen, H., Hoffman, C. & Mercadier, J.J. (1993) Mechanical properties of rat cardiac skinned fibers altered by chronic growth hormone hypersecretion. Circulation Research, 72, 57-64.
34. Markussis, V., Beshiah, S.A., Fisher, C., Sharp, P., Niccolaides, A.N. & Johnston, D.G. (1992) Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults. Lancet, 340, 1188-1192.
35. Mathews, L.S., Enmberg, B. & Norstedt, G. (1989) Regulation of rat growth hormone receptor gene expression. Journal of Biological Chemistry, 17, 9905-9910.
36. Merola, B., Cittadini, A., Colao, A., Longobardi, S., Fazio, S., Sabatini, D., Saccà, L. & Lombardi, G. (1993) Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 77, 1658-1661.
37. Merola, B., Longobardi, S., Sofia, M., Pivonello, R., Micco, A., Di Rella, F., Esposito, V., Colao, A. & Lombardi, G. (1996) Lung Volumes and respiratory muscle strength in adult patients with childhood or adulthood onset GH deficiency. Effect of 12 months GH replacement therapy. European Journal of Endocrinology, 135, 553-558.
38. Miller, T.R., Grossman, S.G., Schechtmun, K.B., Biello, D.R., Ludbrook, P.A. & Ehansi, A.A. (1986) Left ventricular diastolic filling and its association with age. American Journal of Cardiology, 58, 531-535.
39. Moller, J., Frandsen, E., Fisker, S., Jorgensen, J.O.L. & Christiansen, J.S. (1996) Decreased plasma DNA extracellular Volume in growth hormone deficient adults and the acute and prolonged effects of GH administration: a controlled experimental study. Clinical Endocrinology, 44, 533-539.
40. Newman, C.B. & Kleinberg, D.L. (1998) Adult growth hormone deficiency. Endocrinologist, 8, 178-186.
41. Pfeifer, M., Verhovec, R., Zizek, B., Prezelj, J., Poredoö, P. & Clayton, R.N. (1999) Growth hormone (GH) treatment reverses early atherosclerotic changes in GH deficient adults. Journal of Clinical Endocrinology and Metabolism, 84, 453-457.
42. Rosén, T. & Bengtsson, B.A. (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet, 336, 285-288.
43. Rosén, T., Eden, S., Larson, G., Wilhelmsen, L. & Bengtsson, B.A. (1993) Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinologica, 129, 195-200.
44. Saccà, L., Cittadini, A. & Fazio, S. (1994) Growth hormone and the heart. Endocrine Review, 15, 555-573.
45. Shahi, M., Beshyah, S., Hackett, D., Sharp, P., Johnston, D. & Foale, R. (1992) Myocardial dysfunction in treated adult hypopituitarism: a possible explanation for increased cardiovascular mortality. British Heart Journal, 67, 92-96.
46. Timsit, J., Riou, B., Bertherat, J., Wisnewsky, C., Kato, N.S., Weisberg, A.S., Lubetzki, J., Lecarpentier, Y., Winegrad, S. & Mercadier, J.J. (1990) Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern and myosin-adenosin thriphosphatase activity of rat left ventricle. Journal of Clinical Investigation, 86, 507-515.
47. Toogood, A.A., Adams J.E., O'Neill, P.A. & Shalet, S.M. (1996) Body composition in growth hormone deficient adult over the age of 60 years. Clinical Endocrinology, 45, 399-405.
48. Valcavi, R., Gaddi, O., Zini, M., Iavicolli, M., Mellino, U. & Portioli, I. (1995) Cardiac performance and mass in adult with hypopituitarism: effects of one year of growth hormone treatment. Journal of Clinical Endocrinology and Metabolism, 80, 659-666.
49. Vetter, U., Kupferschmid, C., Lang, D. & Pents, S. (1988) Insulin-like growth factors and insulin increase the contractility of neonatal rat cardiocytes in vitro. Basic Research in Cardiology, 83, 647-654.