Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 1, 2003, Pages 107-110

  Price, Melissa L P ^a   Guida, Wayne C ^b,c   Jackson, Tara E ^b   Nydick, Jason A ^b   Gladstone, Patricia L ^a   Juarez, José C ^a   Doñate, Fernando ^a   Ternansky, Robert J ^a  

^a LLC   (United States)

^b ECKERD COLLEGE   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GUANINE DERIVATIVE; PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE; THYMIDINE PHOSPHORYLASE; GUANIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CHEMICAL MODEL; DRUG BINDING; DRUG DESIGN; ENZYME SUBSTRATE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; HUMAN; PROTEIN BINDING; STRUCTURAL HOMOLOGY;

BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; GUANIDINES; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURAL HOMOLOGY, PROTEIN; THYMIDINE PHOSPHORYLASE;

EID: 1842864743     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00828-4     Document Type: Article

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