Acute and chronic effects of T-1032, a novel selective phosphodiesterase type 5 inhibitor, on monocrotaline-induced pulmonary hypertension in rats

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 11, 2002, Pages 1422-1426

  Inoue, Hirotaka ^a   Yano, Koji ^a   Noto, Tsunehisa ^a   Takagi, Michino ^a   Ikeo, Tomihiro ^a   Kikkawa, Kohei ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Monocrotaline rat; Phosphodiesterase type 5; Pulmonary hypertension

Indexed keywords

2 (4 AMINOPHENYL) 1,2 DIHYDRO 1 OXO 7 (2 PYRIDINYLMETHOXY) 4 (3,4,5 TRIMETHOXYPHENYL) 3 ISOQUINOLINECARBOXYLIC ACID METHYL ESTER; ANTIHYPERTENSIVE AGENT; BERAPROST; GLYCERYL TRINITRATE; METHYL 2 (4 AMINOPHENYL) 1,2 DIHYDRO 1 OXO 7 (2 PYRIDYLMETHOXY) 4 (3,4,5 TRIMETHOXYPHENYL) 3 ISOQUINOLINE CARBOXYLATE SULFATE; MONOCROTALINE; PHOSPHODIESTERASE V INHIBITOR; UNCLASSIFIED DRUG; CGMP BINDING, CGMP SPECIFIC 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CGMP-BINDING, CGMP-SPECIFIC 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC GMP PHOSPHODIESTERASE; ISOQUINOLINE DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; DRUG SCREENING; HEART RATE; HEART VENTRICLE CONTRACTION; HEART VENTRICLE REMODELING; LONG TERM CARE; LUNG HEMODYNAMICS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PULMONARY HYPERTENSION; RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; ENZYMOLOGY; METABOLISM; WISTAR RAT;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HYPERTENSION, PULMONARY; ISOQUINOLINES; MALE; MONOCROTALINE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PYRIDINES; RATS; RATS, WISTAR;

EID: 1842847376     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.1422     Document Type: Article

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