Hepcidin: A key iron regulator involved in the pathogenesis of anaemia of chronic disease

HAEMA

Volumn 7, Issue 2, 2004, Pages 165-174

  Politou, Marianna ^a   Papanikolaou, George ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Hemochromatosis; Hepcidin; HFE; HFE2; Iron

Indexed keywords

HEPCIDIN;

ANEMIA; CHRONIC DISEASE; DATA ANALYSIS; DUODENUM; ERYTHROPOIESIS; HEMOCHROMATOSIS; HUMAN; HYPOXIA; INFLAMMATION; IRON ABSORPTION; IRON DEFICIENCY ANEMIA; IRON KINETICS; IRON METABOLISM; IRON OVERLOAD; IRON STORAGE; MACROPHAGE; MICROCYTOSIS; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN SECRETION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; STRUCTURE ANALYSIS;

EID: 1842810290     PISSN: 11082682     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (31)

1. Lieu PT, Heiskala M, Peterson PA, Yang Y. The roles of iron in health and disease. Mol Aspects Med 2001; 22: 1-87.
2. Roy CN, Enns CA. Iron homeostasis: new tales from the crypt. Blood 2000; 96: 4020-4027.
3. Andrews NC. Iron homeostasis: insights from genetics and animal models. Nat Rev Genet 2000; 3: 208-217.
4. Andrews NC. Disorders of iron metabolism. N Engl J Med 1999; 341: 1986-1995.
5. Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806-7810.
6. Krause A, Neitz S, Magert HJ et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000; 480: 147-150.
7. Hunter HN, Fulton DB, Ganz T, Vogel HJ. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 2002; 277: 37597-37603.
8. Kluver E, Schulz A, Forssmann WG, Adermann K. Chemical synthesis of beta-defensins and LEAP-1/hepcidin. J Pept Res 2002; 59: 241-248.
9. Pigeon C, Ilyin G, Courselaud B et al O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001; 276: 7811-7819.
10. Nemeth E, Valore EV, Territo M et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101: 2461-2463.
11. Nicolas G, Bennoun M, Devaux I et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 2001; 98: 8780-8785.
12. Nicolas G, Bennoun M, Porteu A et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002; 99: 4596-4601.
13. Frazer DM, Wilkins SJ, Becker EM et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002; 123: 835-844.
14. Shike H, Lauth X, Westerman ME et al. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur J Biochem. 2002; 269: 2232-2237.
15. Nicolas G, Chauvet C, Viatte L et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002; 110: 1037-1044.
16. Weinstein DA, Roy CN, Fleming MD et al. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002; 100: 3776-3781.
17. Nicolas G, Viatte L, Bennoun M et al. Hepcidin, a new iron regulatory peptide. Blood Cells Mol Dis 2002; 29: 327-335.
18. Fleming RE, Sly WS. Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. Proc Natl Acad Sci U S A 2001; 98: 8160-8162.
19. Roetto A, Papanikolaou G, Politou M et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003; 33: 21-22.
20. Roetto A, Daraio F, Porporato P et al. Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70r). Blood 2003; 20 [Epub ahead of print].
21. De Gobbi M, Roetto A, Piperno A et al. Natural history of juvenile haemochromatosis. Br J Haematol 2002; 117: 973-979.
22. Papanikolaou G, Samuels ME, Ludwig EH et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 2003 Nov 30 [Epub ahead of print].
23. Ahmad KA, Ahmann JR, Migas MC, et al. Decreased liver hepcidin expression in the hfe knockout mouse. Blood Cells Mol Dis 2002; 29: 361-366.
24. Bridle KR, Frazer DM, Wilkins SJ et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003; 361: 669-677.
25. Gehrke SG, Kulaksiz H, Herrmann T et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to serum transferrin saturation and non-transferrin-bound iron. Blood 2003; 102: 371-376.
26. Roetto A, Daraio F, Alberti F et al. Hemochromatosis due to mutations in transferrin receptor 2. Blood Cells Mol Dis 2002; 29: 465-470.
27. Montosi G, Donovan A, Totaro A et al. Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. J Clin Invest 2001; 108: 619-623.
28. Njajou OT, de Jong G, Berghuis B et al. Dominant Hemochromatosis Due to N144H Mutation of SLC11A3: Clinical and Biological Characteristics. Blood Cells Mol Dis 2002; 29: 439-443.
29. Merryweather-Clarke AT, Cadet E, Bomford A et al. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Hum Mol Genet 2003; 12: 2241-2247.
30. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003; 102: 783-788.
31. Nicolas G, Viatte L, Lou DQ, Bennoun M et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet 2003; 34: 97-101.