Moisture transfer into medicament chambers equipped with a double-barrier-desiccant system

International Journal of Pharmaceutics

Volumn 275, Issue 1-2, 2004, Pages 155-164

  Lehto, Vesa Pekka ^a   Lankinen, Tapio ^b  

^a UNIVERSITY OF TURKU   (Finland)

^b Focus Inhalation Oy   (Finland)

Author keywords

t; ABS; CL; Langmuir constant; mingr; Polyacrylonitrile butadiene styrene; Time interval between the steps of the iterative simulation cyclesm; Weight of the moisture adsorbed on the desiccant during the measurement

Indexed keywords

ARTICLE; CORRELATION ANALYSIS; DESICCATION; DRY POWDER; HUMIDITY; MOISTURE; PERMEABILITY BARRIER; POWDER INHALER; PRIORITY JOURNAL; SIMULATION;

DESICCATION; DRUG COMPOUNDING; DRUG STABILITY; HUMIDITY; NEBULIZERS AND VAPORIZERS; PHARMACEUTICAL PREPARATIONS; POWDERS; TIME FACTORS; WATER;

EID: 1842789745     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.01.026     Document Type: Article

References (19)

1. Badawy S., Gawronski A., Alvarez F. Application of sorption-desorption moisture transfer modeling to the study of chemical stability of a moisture sensitive drug product in different packing configurations. Int. J. Pharm. 223:2001;1-13.
2. Bérard V., Lesniewska E., Andrès C., Pertuy D., Laroche C., Pourcelot Y. Dry powder inhaler: influence of humidity on topology and adhesion studied by AFM. Int. J. Pharm. 232:2002;213-224.
3. Busnaina A., Elsawy T. The effect of relative humidity on particle adhesion and removal. J. Adhesion. 74:2000;391-409.
4. Eilbeck J., Rowley G., Carter P.A., Fletcher E.J. Effect of contamination of pharmaceutical equipment on powder triboelectrification. Int. J. Pharm. 195:2000;7-11.
5. Greason W. Investigation of a test methodology for triboelectrification. J. Electrostat. 49:2000;245-256.
6. Hinrichs W.L.J., Prinsen M.G., Frijlink H.W. Inulin glasses for the stabilization of therapeutic proteins. Int. J. Pharm. 215:2001;163-174.
7. Jashnani R., Byron P. Dry powder aerosol generation in different environments: performance comparison of albuterol, albuterol sulfate, albuterol adipate and albuterol stearate. Int. J. Pharm. 130:1996;13-24.
8. Kappl M., Butt H.-J. The colloidal probe technique and its application to adhesion force measurements. Part. Part. Syst. Char. 19:2002;129-143.
9. Keller, M., Müller, R., 2000. Dry powder for inhalation. Intern. Patent WO,00/28979 (25 May).
10. Kontny M., Koppenol S., Graham E. Use of the sorption-desorption moisture transfer model to assess the utility of a desiccant in a solid product. Int. J. Pharm. 84:1992;261-271.
11. Lankinen, T., 1994. Device intended for measuring a dose of powdered medicament for inhalation. U.S. Patent 5,295,479 (22 March).
12. Lankinen, T., 2000. Medicament chamber in an inhalation apparatus. U.S. Patent 6,132,394 (17 October).
13. Podczeck F., Newton M., James M. Variations in the adhesion force between a drug and carrier particles as a result of changes in the relative humidity of the air. Int. J. Pharm. 149:1997;151-160.
14. Price R., Young P.M., Edge S., Staniforth J.N. The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations. Int. J. Pharm. 246:2002;47-59.
15. Sedin D., Rowlen K. Adhesion forces measured by atomic force microscopy in humid air. Anal. Chem. 72:2000;2183-2189.
16. Woodhead S.R., Armour-Chélu D.I. The influence of humidity, temperature and other variables on the electric charging characteristics of particulate aluminium hydroxide in gas-solid pipeline flows. J. Electrostat. 58:2003;171-183.
17. Young P., Price R., Tobyn M., Buttrum M., Dey F. Pre-formulation characterisation of dry powders for inhalation by atomic force microscopy: the effect of relative humidity on particle cohesion. Respir. Drug Deliv. 2:2002;671-673.
18. Yu L. Amorphous pharmaceutical solids: preparation, characterization and stabilization. Adv. Drug Deliv. Rev. 48:2001;27-42.
19. Zografi G., Grandolfi G., Kontny M., Mendenhall D. Prediction of moisture transfer in mixtures of solids: transfer via vapor phase. Int. J. Pharm. 42:1988;77-88.