The prostaglandin E1 analog misoprostol reduces symptoms and microvascular arteriovenous shunting in erythromelalgia - A double-blind, crossover, placebo-compared study

Journal of Investigative Dermatology

Volumn 122, Issue 3, 2004, Pages 587-593

  Mørk, Cato ^a   Salerud, E Göran ^b   Asker, Claes L ^c   Kvernebo, Knut ^d  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b LINKÖPING UNIVERSITY   (Sweden)

^c KARLSTAD UNIVERSITY   (Sweden)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Arteriovenous shunting; Clinical trial; Microcirculation; Prostanoids

Indexed keywords

MISOPROSTOL; PLACEBO; PROSTAGLANDIN E1 DERIVATIVE;

ABDOMINAL PAIN; ADULT; AGED; ARTERIOVENOUS SHUNT; ARTICLE; CAPILLARY DENSITY; CIGARETTE SMOKING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COOLING; CROSSOVER PROCEDURE; DIARRHEA; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG SAFETY; ERYTHROMELALGIA; FEMALE; FLATULENCE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; INSOMNIA; MALE; MICROCIRCULATION; NAUSEA; PAIN; PRIORITY JOURNAL; SKIN BLOOD FLOW; SORE THROAT; VOMITING;

EID: 1842740341     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.22339.x     Document Type: Article

References (26)

1. Arildsson M, Asker CL, Salerud EG, Strömberg T: Skin capillary appearance and skin microvascular perfusion due to topical application of analgesia cream. Microvasc Res 59:14-23, 2000
2. Belch JJF: Erythromelalgia: A personal perspective. J Dermatol Treat 3:153-158, 1992
3. Cohen JS: Erythromelalgia: New theories and new therapies. J Am Acad Dermatol 43:841-847, 2000
4. Davis MD, Rooke T: Erythromelalgia. Curr Treat Options Cardiovasc Med 4:207-222, 2002
5. Davis MD, Sandroni P: Lidocaine patch for pain of erythromelalgia. Arch Dermatol 138:17-19, 2002
6. Drenth JPH, Vuzevski V, van Joost T, Casteelsvandaele M, Vermylen J, Michiels JJ: Cutaneous pathology in primary erythromelalgia. Am J Dermatol 18:30-34, 1996
7. Grant RT, Bland EF: Observations on arteriovenous anastomoses in human skin and in the bird's foot with special reference to the reaction to cold. Heart 15:385-407, 1931
8. Jørgensen HP, Søndegaard J: Pathogenesis of erythromelalgia. Arch Dermatol 114:112-114, 1978
9. Kalgaard OM, Seem E, Kvernebo K: Erythromelalgia: A clinical study of 87 cases. J Intern Med 242:191-197, 1997
10. Kalgaard OM, Mørk C, Kvernebo K: Prostacyclin reduces symptoms and reverses the sympathetic dysfunction in erythromelalgia in a double blind randomised pilot study. Acta Dermatol Venereol 83:442-444, 2003
11. Kvernebo K: Erythromelalgia - A disease caused by microvascular shunting. VASA 51 (suppl):1-39, 1998
12. Littleford RC, Khan F, Belch JJF: Skin perfusion in patients with erythromelalgia. Eur J Clin Invest 29:588-593, 1999a
13. Littleford RC, Khan F, Belch JJF: Impaired skin vasomotor reflexes in patients with erythromelalgia. Clin Sci 96:507-512, 1999b
14. Mørk C, Asker CL, Salerud G, Kvernebo K: Microvascular arteriovenous shunting is a probable pathogenetic mechanism in erythromelalgia. J Invest Dermatol 114:643-646, 2000
15. Mørk C, Kalgaard OM, Kvernebo K: Impaired neurogenic control of skin perfusion in erythromelalgia. J Invest Dermatol 118:699-703, 2002b
16. Mørk C, Kvernebo K: Erythromelalgia - therapeutic strategies. In: Lebwohl M, Heymann WR, Berth-Jones J, Coulson I (eds). Treatment of Skin Disease. Comprehensive Therapeutic Strategies. St Louis, MO: Mosby, 2002; p 212-214
17. Mørk C, Kvernebo K, Asker CL, Salerud EG: Reduced skin capillary density during attacks of erythromelalgia implies arteriovenous shunting as pathogenetic mechanism. J Invest Dermatol 119:949-953, 2002a
18. Nilsson GE, Salerud EG, Strömberg T, Wårdell K: Laser doppler perfusion monitoring and imaging. In: Tual Vo Dinh (ed). Biomedical Photonics Handbook. Boca Raton, FL: CRC Press, 2003; p 1-24
19. Özsoylu S, Coskun T: Sodium nitroprusside treatment in erythromelalgia. Eur J Paediatr 141:185-187, 1984
20. Sandroni P, Davis MDP, Harper CM Jr, Rogers RS III, O'Fallon WM, Rooke TW, Low PA: Neurophysiologic and vascular studies in erythromelalgia: A retrospective analysis. J Clin Neuromuscular Dis 1:57-63, 1999
21. Sherman JL: Normal arteriovenous anastomoses. Medicine (Baltimore) 42:247-267, 1963
22. Smith LA, Allen EV: Erythermalgia (erythromelalgia) of the extremities. A syndrome characterised by redness, heat and pain. Am Heart J 16:175-188, 1938
23. Thompson GH, Hahn G, Rang M: Erythromelalgia. Clin Orthop 144:249-254, 1979
24. Torrance GW, Feeny D, Furlong W: Visual analog scales: Do they have a role in the measurement of preferences for health states? Med Decis Making 21:329-334, 2001
25. Van Genderen PJ, Lucas IS, van Strik R, Vuzevski VD, Prins FJ, van Vliet HH, Michiels JJ: Erythromelalagia in essential thrombocythemia is characterized by platelet activation and endothellal cell damage but not by thrombin generation. Thromb Haemost 76:333-338, 1996
26. Zhong J, Asker CL, Salerud EG: Imaging, image processing and pattern analysis of skin capillary ensembles. Skin Res Technol 6:45-57, 2000