Erythromelalgia in essential thrombocythemia is characterized by platelet activation and endothelial cell damage but not by thrombin generation

Thrombosis and Haemostasis

Volumn 76, Issue 3, 1996, Pages 333-338

  Van Genderen, Perry J J ^a   Lucas, Irene S ^a   Van Strik, Roel ^b   Vuzevski, Vojislav D ^c   Prins, Fransisco J ^a   Van Vliet, Huub H D M ^a   Michiels, Jan J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Inst of Epidemiol and Biostatist   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; BETA THROMBOGLOBULIN; FIBRIN; FIBRINOGEN DEGRADATION PRODUCT; HEPARIN; PROTHROMBIN; THROMBIN; THROMBOCYTE FACTOR 4; THROMBOMODULIN; VON WILLEBRAND FACTOR; WARFARIN;

ADULT; AGED; ARTERY OCCLUSION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDOTHELIUM CELL; ERYTHROMELALGIA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; SKIN BIOPSY; SYMPTOM; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTHEMIA; THROMBOSIS; VASCULAR ENDOTHELIUM;

EID: 0029847674     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1650579     Document Type: Article

References (21)

1. Michiels JJ, Abels J, Steketee J, van Vliet HHDM, Vuzevski VD. Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia. Ann Intern Med 1985; 102: 466-71.
2. van Genderen PJJ, Michiels JJ. Primary thrombocythemia: diagnosis, clinical manifestations and management. Ann Hematol 1993; 67: 57-62.
3. Michiels JJ, van Joost Th. Erythromelalgia and thrombocythemia: a causal relation. Am J Acad Dermatol 1990; 22: 107-11.
4. Michiels JJ, Ten Kate FWJ, Vuzevski VD, Abels J. Histopathology of erythromelalgia in thrombocythemia. Histopathology 1984; 8: 669-78.
5. van Genderen PJJ, Michiels JJ, van Strik R, Lindemans J, van Vliet HHDM. Platelet consumption in thrombocythemia complicated by erythromelalgia: reversal by aspirin. Thromb Haemost 1995; 73: 210-4.
6. Vreeken J, van Aken WG. Spontaneous aggregation of blood platelets as a cause of idiopathic thrombosis and recurrent painful toes and fingers. Lancet 1971; ii: 1394-7.
7. Murphy S, Hand H, Rosenthal D, Laszlo J. Essential thrombocythemia: an interim report from the Polycythemia Vera Study Group. Sem Hematol 1986; 23: 177-82.
8. Rocca B, Ciabattoni G, Tartaglione R, Cortelazzo S, Barbui T, Patrono C, Landolfi R. Increased thromboxane biosynthesis in essential thrombocythemia. Thromb Haemost 1995; 74: 1225-30.
9. Patrignani P, Filabozzi P, Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 1982; 69: 1366-72.
10. Cortelazzo S, Viero P, Barbui T. Platelet activation in myeloproliferative disorders. Thromb Haemost 1981; 45: 211-3.
11. Lendrum AC, Fraser DS, Slidders W, Henderson R. Studies on the character and staining of fibrin. J Clin Path 1962; 15: 401-13.
12. Bellucci S, Ignatova E, Jaillet N, Boffa MC. Platelet hyperactivation in patients with essential thrombocythemia is not associated with vascular endothelial damage as judged by the level of plasma thrombomodulin, protein S, PAI-1, t-PA and vWF. Thromb Haemost 1993; 70: 736-42.
13. Wada H, Ohiwa M, Kaneko T, Tamaki S, Tanigawa M, Shirakawa S, Koyama M, Hayashi T, Suzuki K. Plasma thrombomodulin as a marker of vascular disorders in thrombotic thrombocytopenic purpura and disseminated intravascular coagulation. Am J Hematol 1992; 3: 20-4.
14. Karmochkine M, Boffa MC, Piette JC, Cacoub P, Wechsler B, Godeau P, Juhan I, Weiller PJ. Increase in plasma thrombomodulin in lupus erythematosus with antiphospholipid antibodies. Blood 1992; 79: 837-8.
15. Tanaka A, Ishii H, Hiraishi S, Kazama M, Mazewa H. Increased thrombomodulin values in plasma of diabetic men with microangiopathy. Clin Chem 1991; 37: 269-72.
16. Tani N, Hada K, Kitami A, Nakano M, Takahashi H, Ito S, Sato I, Shibata A. Effects of acetyl salicylic acid and cilostazol administration on serum thrombomodulin concentration in diabetic patients. Thromb Res 1993; 69: 153-8.
17. Szczeklik A, Krzanowski M, Gora P, Radwan J. Antiplatelet drugs and generation of thrombin in cloning blood. Blood 1992; 80: 2006-11.
18. Kessels H, Beguin S, Andree H, Hemker HC. Measurement of thrombin generation in whole blood - the effect of heparin and aspirin. Thromb Haemost 1994; 72: 78-83.
19. Asada Y, Sumiyoshi A, Hayashi T, Suzumiya J, Kaketani K. Immunohistochemistry of vascular lesion in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen. Thromb Res 1985; 38: 469-79.
20. Moake JL. Haemolytic-uraemic syndrome: basic science. Lancet 1994; 343: 393-7.
21. Yosipovitch, Ilan Krause, Blickstein D. Erythromelalgia in a patient with thrombotic thrombocytopenic purpura. J Am Acad Dermatol 1992; 26: 825-7.