Laser doppler perfusion monitoring and imaging

Biomedical Photonics: Handbook

Volumn , Issue , 2003, Pages 15-1-15-24

  Nilsson, Gert E ^a   Salerud, E Göran ^a   Strömberg, N O Tomas ^a   Wårdell, Karin ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84861964624     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (168)

1. Rhodin, J.A.G., Anatomy of the microcirculation, in Microcirculation: Current Physiologic, Medical and Surgical Concepts., Effros, R.M., Schmid-Schoenbein, H., and Dietzel, J., Eds., Academic Press, New York, 1981, p. 11.
2. Tenland, T., Salerud, E.G., Nilsson, G.E., and Öberg, P.Å., Spatial and temporal variations in human skin blood flow, Int. J. Microcirc. Clin. Exp., 2(2), 81, 1983.
3. Salerud, E.G., Tenland, T., Nilsson, G.E., and Öberg, P.Å., Rhythmical variations in human skin blood flow, Int. J. Microcirc. Clin. Exp., 2(2), 91, 1983.
4. Braverman, I.M., Keh, K., and Goldminz, D., Correlation of laser Doppler wave patterns with underlying microvascular anatomy, J. Invest. Dermatol., 95(3), 283, 1990.
5. Hertzman, A.B. and Spealman, C.R., Observation on the finger volume pulse recorded photoelectrically, Am. J. Physiol., 119, 334, 1937.
6. Challoner, A.V.J., Photoelectric plethysmography for estimating cutaneous blood flow, in Non- Invasive Physiological Measurements, Vol. 1, Rolfe, P., Ed., Academic Press, London, 1979, p. 125.
7. Holti, G. and Mitchell, K.W., Estimation of the nutrient skin blood flow using a non-invasive segmented thermal probe, in Non-Invasive Physiological Measurements, Vol. 1, Rolfe, P., Ed., Academic Press, London, 1979, p. 113.
8. Kety, S.S., Measurement of regional circulation by the local clearance of radioactive sodium, Am. Heart J., 38, 321, 1949.
9. Sejrsen, P., Measurement of cutaneous blood flow by freely diffusable radioactive isotopes. Methodological studies on the washout of krypton-85 and xenon-13 from the cutaneous tissue in man, Dan. Med. Bull., 18(Suppl 3), 9, 1971.
10. Groner, W., Winkelman, J.W., Harris, A.G., Ince, C., Bouma, G.J., Messmer, K., and Nadeau, R.G., Orthogonal polarization spectral imaging: a new method for study of the microcirculation, Nat. Med., 5(10), 1209, 1999.
11. Nadeau, R.G. and Groner, W., The role of a new noninvasive imaging technology in the diagnosis of anemia, J. Nutr., 131(5), 1610S, 2001.
12. Wayland, H. and Johnson, P.C., Erythrocyte velocity measurements in microvessels by a two-slit photometric method, Am. J. Physiol., 22, 333, 1967.
13. Bollinger, A., Butti, P., Barras, J.P., Trachsler, H., and Siegenthaler, W., Red blood cell velocity in nailfold capillaries of man measured by a television microscopy technique, Microvasc. Res., 7, 61, 1974.
14. Doppler, J.C., Über das farbige Licht der Doppelsterne und einiger anderer Gestirne des Himmels [On the colored light from double stars and some other heavenly bodies], Abh. Konigl. Böhmischen Ges. Wiss., 5, 465, 1842 (Treatises of the Royal Bohemian Society of Science).
15. Riva, C., Ross, B. and Benedek, G.B., Laser Doppler measurements of blood flow in capillary tubes and retinal arteries, Invest. Ophthalmol., 11(11), 936, 1972.
16. Mishina, H., Koyama, T., and Asakura, T., Velocity measurements of blood flow in the capillary and vein using the laser Doppler microscope., Appl. Opt., 14, 2326, 1974.
17. Einav, S., Berman, H.J., Fuhro, R.L., DiGiovanni, P.R., Fridman, J.D., and Fine, S., Measurement of blood flow in vivo by laser Doppler anemometry through a microscope, Biorheology, 12(3-4), 203, 1975.
18. Stern, M.D., In vivo evaluation of microcirculation by coherent light scattering, Nature, 254(5495), 56, 1975.
19. Holloway, G.A., Jr. and Watkins, D.W., Laser Doppler measurement of cutaneous blood flow, J. Invest. Dermatol., 69(3), 306, 1977.
20. Nilsson, G.E., Tenland, T., and Öberg, P.Å., A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy, IEEE Trans. Biomed. Eng., 27(1), 12, 1980.
21. Nilsson, G.E., Tenland, T., and Öberg, P.Å., Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow, IEEE Trans. Biomed. Eng., 27(10), 597, 1980.
22. Bonner, R. and Nossal, R., Model for laser Doppler measurements of blood flow in tissue, Appl. Opt., 20, 2097, 1981.
23. Leahy, M.J., de Mul, F.F., Nilsson, G.E., and Maniewski, R., Principles and practice of the laser- Doppler perfusion technique, Technol. Health Care, 7(2-3), 143, 1999.
24. Shepherd, A.P. and Öberg, P.Å., Eds., Laser-Doppler Blood Flowmetry, Kluwer Academic, Boston, 1990.
25. Öberg, P.Å., Laser Doppler flowmetry, Crit. Rev. Biomed. Eng., 18(2), 125, 1990.
26. Belcaro, G., Hoffmann, U., Bollinger, A., and Nicolaides, A., Eds., Laser Doppler, Med-Orion, London, 1994.
27. Hill, S.A., Pigott, K.H., Saunders, M.I., Powell, M.E., Arnold, S., Obeid, A., Ward, G., Leahy, M., Hoskin, P.J., and Chaplin, D.J., Microregional blood flow in murine and human tumours assessed using laser Doppler microprobes, Br. J. Cancer, Suppl 27, S260, 1996.
28. Nilsson, G.E., Jakobsson, A., and Wårdell, K., Imaging of tissue blood flow by coherent light scattering, in IEEE 11th Annu. EMBS Conf., Seattle, WA, 1989.
29. Essex, T.J. and Byrne, P.O., A laser Doppler scanner for imaging blood flow in skin, J. Biomed. Eng., 13(3), 189, 1991.
30. Wårdell, K., Jakobsson, A., and Nilsson, G.E., Laser Doppler perfusion imaging by dynamic light scattering, IEEE Trans. Biomed. Eng., 40(4), 309, 1993.
31. Sommer, A., Laser Doppler imaging in dermatology — experimental and clinical applications — time to replace the dermatologist’s eye? in Dermatology, University of Maastricht, Maastricht, the Netherlands, 2001.
32. Gschwandtner, M.E., Ambrozy, E., Schneider, B., Fasching, S., Willfort, A., and Ehringer, H., Laser Doppler imaging and capillary microscopy in ischemic ulcers, Atherosclerosis, 142(1), 225, 1999.
33. Pape, S.A., Skouras, C.A., and Byrne, P.O., An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth, Burns, 27(3), 233, 2001.
34. Bircher, A., de Boer, E.M., Agner, T., Wahlberg, J.E., and Serup, J., Guidelines for measurement of cutaneous blood flow by laser Doppler flowmetry. A report from the Standardization Group of the European Society of Contact Dermatitis, Contact Dermatitis, 30(2), 65, 1994.
35. Fullerton, A., Stücker, M., Wilhelm, K., Wårdell, K., Anderson, C., Fischer, T., Nilsson, G.E., and Serup, J., Guidelines for visualisation of cutaneous blood flow by laser Doppler perfusion imaging, Contact Dermatitis, 46(3), 129, 2002.
36. Nilsson, G.E., Jakobsson, A., and Wårdell, K., Tissue perfusion monitoring and imaging by coherent light scattering, in Biooptics: Optics in Biomedicine and Environmental Studies, Soares, O.D.D. and Scheggi, A.M., Eds., Proc. SPIE, 1524, 90, 1992.
37. Steenbergen, W. and deMul, F.F.M., Role of speckles in laser Doppler flowmetry, in Optical Diagnostics of Biological Fluids, Proc. SPIE, San Jose, CA, 1998.
38. Siegman, A.E., The antenna properties of optical heterodyne receiver, Appl. Opt., 5(10), 1588, 1966.
39. Serov, A., Steenbergen, W., and deMul, F.F.M., Prediction of the photodetector signal generated by Doppler-induced speckle fluctuations, theory and some validations, J. Opt. Soc. Am. A, 18(3), 622, 2001.
40. Berne, B.J. and Pecora, R., Dynamic Light Scattering, New York, Wiley, 1976.
41. Cummins, H.Z. and Swinney, H.L., Light beating spectroscopy, in Progr. Opt., Wolf, E., Ed., North- Holland Publishing Co., Amsterdam, 1970, p. 133.
42. Jakobsson, A. and Nilsson, G.E., Prediction of sampling depth and photon pathlength in laser Doppler flowmetry, Med. Biol. Eng. Comput., 31(3), 301, 1993.
43. Nilsson, H. and Nilsson, G., Monte Carlo simulations of the light interaction with blood vessels in human skin in the red wavelength region, in Optical Diagnostics of Biological Fluids III, BiOS’98, SPIE, San Jose, CA, 1998.
44. Jentink, H.W., Demul, F.F.M., Graaff, R., Suichies, H.E., Aarnoudse, J.G., and Greve, J., Laser Doppler flowmetry — measurements in a layered perfusion model and Monte-Carlo simulations of measurements, Appl. Opt., 30(18), 2592, 1991.
45. Koelink, M.H., deMul, F.F.M., Greve, J., Graaf, R., Dassel, A.C.M., and Aarnoudse, J.G., Laser- Doppler blood flowmetry using two wavelengths: Monte Carlo simulations and measurements, Appl. Opt., 33(16), 3549, 1994.
46. Stern, M.D., Lappe, D.L., Bowen, P.D., Chimosky, J.E., Holloway, G.A., Jr., Keiser, H.R., and Bowman, R.L., Continuous measurement of tissue blood flow by laser-Doppler spectroscopy, Am. J. Physiol., 232, H441, 1977.
47. Salerud, E.G. and Öberg, P.Å., Single-fiber laser Doppler flowmetry, a method for deep tissue perfusion measurements, Med. Biol. Eng. Comput., 25, 329, 1987.
48. Kvernebo, K., Staxrud, L.E., and Salerud, E.G., Assessment of human muscle blood perfusion with single-fiber laser Doppler flowmetry, Microvasc. Res., 39, 376, 1990.
49. Nilsson, G.E., Perimed’s LDV flowmeter, in Laser-Doppler Flowmetry, Shepherd, A.P. and Öberg, P.Å., Eds., 1990, Kluwer Academic Publisher: Boston, Dordrecht, London, 57.
50. Watkins, D. and Holloway, G.A., An instrument to measure cutaneous blood flow using the Doppler shift of laser light, IEEE Trans. Biomed. Eng., 28, 1978.
51. Holloway, G.A., Medpacifićs LDV blood flowmeter, in Laser-Doppler Blood Flowmetry, Shepherd, A.P. and Öberg, P.Å., Eds., Kluwer Academic, Dordrecht, 1990, p. 47.
52. Gush, R.J. and King, T.A., Investigation and improved performance of optical fibre probes in laser Doppler blood flow measurement, Med. Biol. Eng. Comput., 25, 391, 1987.
53. Newson, T.P., Obeid, A., Wolton, R.S., Boggett, D., and Rolfe, P., Laser Doppler velocimetry: the problem of fibre movement artefact, J. Biomed. Eng., 9, 169, 1987.
54. Obeid, A.N., Barnett, N.J., Dougherty, G., and Ward, G., A critical review of laser Doppler flowmetry, J. Med. Eng. Technol., 14, 178, 1990.
55. Kolari, P., Optoelectronic Doppler velocimetry based on semiconductor laser diode for measurements of cutaneous blood flow, Int. J. Microcirc. Clin. Exp., 3, 476, 1984.
56. deMul, F.F.M., van Spijker, J., van der Plas, D., Greve, J., Aarnoudse, J.G., and Smits, T.M., Mini laser-Doppler (blood) flow monitor with diode laser source and detection integrated in the probe, Appl. Opt., 23, 2970, 1984.
57. Kvernmo, H.D., Stefanovska, A., Bracic, M., Kirkeboen, K.A., and Kvernebo, K., Spectral analysis of the laser Doppler perfusion signal in human skin before and after exercise, Microvasc. Res., 56, 173, 1998.
58. Kano, T., Shimoda, O., Higashi, H., Sadanaga, M., and Sakamoto, S., Fundamental patterns and characteristics of the laser-Doppler skin blood flow waves recorded from the finger and toe, J. Auton. Nerv. Syst., 45, 191, 1993.
59. Kano, T., Shimoda, O., Higashi, K., and Sadanaga, M., Effects of neural blockade and general anesthesia on the laser-Doppler skin blood flow waves recorded from the finger or toe, J. Auton. Nerv. Syst., 48, 257, 1994.
60. Nilsson, G.E., Signal processor for laser Doppler tissue flowmeters, Med. Biol. Eng. Comput., 22, 343, 1984.
61. Duteil, L., Bernengo, J., and Schalla, W., A double wavelength laser Doppler system to investigate skin microcirculation, IEEE Trans. Biomed. Eng., 439, 1985.
62. Gush, R.J. and King, T.A., Discrimination of capillary and arterio-venular blood flow in skin by laser Doppler flowmetry, Med. Biol. Eng. Comput., 29, 387, 1991.
63. Johansson, K., Jakobsson, A., Lindahl, K., Lindhagen, J., Lundgren, O., and Nilsson, G.E., Influence of fibre diameter and probe geometry on the measuring depth of laser Doppler flowmetry in the gastrointestinal application, Int. J. Microcirc. Clin. Exp., 10, 219, 1991.
64. Gush, R.J., King, T.A., and Jayson, M.I., Aspects of laser light scattering from skin tissue with application to laser Doppler blood flow measurement, Phys. Med. Biol., 29, 1463, 1984.
65. Salerud, E.G. and Nilsson, G.E., Integrating probe for tissue laser Doppler flowmeters. Med. Biol. Eng. Comput., 24, 415, 1986.
66. deMul, F.F.M., Van Spijker, J., Van der Place, D., Greve, J., Aarndoudse, J.D., and Smits, T.M., Mini laser-Doppler (blood) flow monitor with diode laser source and detection integrated in the probe, Appl. Opt., 23, 2970, 1984.
67. Wahlberg, E.P., Effects of local hyperemia and edema on the biological zero in laser Doppler fluxmetry (LD), Int. J. Microcirc. Clin. Exp., 11, 157, 1984.
68. Kernick, D.P., Tooke, J.E., and Shore, A.C., The biological zero signal in laser Doppler fluximetry — origins and practical implications, Pfluegers Arch. Eur. J. Physiol., 437, 624, 1999.
69. Colantuoni, A., Bertuglia, S., and Intaglietta, M., Biological zero of laser Doppler fluxmetry, microcirculatory correlates in the hamster cheek pouch during flow and no flow conditions, Int. J. Microcirc. Clin. Exp., 13, 125, 1993.
70. Abbot, N.C. and Beck, J.S., Biological zero in laser Doppler measurements in normal, ischaemic and inflamed human skin, Int. J. Microcirc. Clin. Exp., 12, 89, 1993.
71. Kvernebo, K., Slagsvold, C.E., and Gjolberg, T., Laser Doppler flux reappearance time (FRT) in patients with lower limb atherosclerosis and healthy controls, Eur. J. Vasc. Surg., 2, 171, 1988.
72. Kvernebo, K., Laser Doppler flowmetry in evaluation of lower limb atherosclerosis, J. Oslo City Hosp., 38, 127, 1988.
73. Braverman, I.M. and Schechner, J.S., Contour mapping of the cutaneous microvasculature by computerized laser Doppler velocimetry, J. Invest. Dermatol., 97, 1013, 1991.
74. Wårdell, K., Braverman, I.M., Silverman, D.G., and Nilsson, G.E., Spatial heterogeneity in normal skin perfusion recorded with laser Doppler imaging and flowmetry, Microvasc. Res., 48, 26, 1994.
75. Arildsson, M., Nilsson, G.E., and Wårdell, K., Critical design parameters in laser Doppler perfusion imaging, SPIE Proc., Opt. Diagn. Living Cells Biofluids, 2678, 401, 1996.
76. Mack, G.W., Assessment of cutaneous blood flow by using topographical perfusion mapping techniques, J. Appl. Physiol., 85, 353, 1998.
77. Wårdell, K. and Nilsson, G.E., Duplex laser Doppler perfusion imaging, Microvasc Res., 52, 171, 1996.
78. Lindén, M., Sirsjö, A., Lindbom, L., Nilsson, G., and Gidlof, A., Laser-Doppler perfusion imaging of microvascular blood flow in rabbit tenuissimus muscle, Am. J. Physiol., 269(4 Pt 2), H1496, 1995.
79. Steenbergen, W. and deMul, F.F.M., New optical tissue phantom, and its use for studying laser Doppler blood flowmetry, in Optical and Imaging Techniques for Biomonitoring, Foth, H.-J., Marchesini, R., and Podbielska, H., Eds., Proc. SPIE, 1997.
80. Larsson, M., Steenbergen, W., and Strömberg, T., Influence of tissue phantom optical properties and emitting-receiving fiber distance on laser Doppler flowmetry, in Optical Diagnostics of Biological Fluids, Priezzhev, A.V. and Asahura, T., Eds., Proc. SPIE, 2000.
81. Shepherd, A.P., Riedel, G.L., Kiel, J.W., Haumschild, D.J., and Maxwell, L.C., Evaluation of an infrared laser-Doppler blood flowmeter, Am. J. Physiol., 252(6 Part 1), G832, 1987.
82. Ahn, H., Lindhagen, J., Nilsson, G.E., Salerud, E.G., Jodal, M., and Lundgren, O., Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat, Gastroenterology, 88, 951, 1985.
83. Ahn, H., Johansson, K., Lundgren, O., and Nilsson, G.E., In vivo evaluation of signal processors for laser Doppler tissue flowmeters, Med. Biol. Eng. Comput., 25, 207, 1987.
84. Liebert, A., Leahy, M., and Maniewski, R., A calibration standard for laser-Doppler perfusion measurements, Rev. Sci. Instrum., 66, 5169, 1995.
85. Stern, M.D., Bowen, P.D., Parma, R., Osgood, R.W., Bowman, R.L., and Stein, J.H., Measurement of renal cortical and medullary blood flow by laser-Doppler spectroscopy in the rat, Am. J. Physiol., 236, F80, 1979.
86. Roman, R.J. and Smits, C., Laser-Doppler determination of papillary blood flow in young and adult rats, Am. J. Physiol., 251(1 Pt 2), F115, 1986.
87. Arvidsson, D., Svensson, H., and Haglund, U., Laser-Doppler flowmetry for estimating liver blood flow, Am. J. Physiol., 254(4 Pt 1), G471, 1988.
88. Pedrosa, M.E., Montero, E.F., and Nigro, A.J., Liver microcirculation after selective denervation, Microsurgery, 21, 163, 2001.
89. Feld, A.D., Fondacaro, J.D., Holloway, G.A., and Jacobson, E.D., Laser Doppler velocimetry, a new technique for the measurement of intestinal mucosal blood flow, Gastrointestinal Endosc., 30, 225, 1984.
90. Ahn, H., Lindhagen, J., Nilsson, G.E., Öberg, P.Å., and Lundgren, O., Assessment of blood flow in the small intestine with laser Doppler flowmetry, Scand. J. Gastroenterol., 21, 863, 1986.
91. Bogaert, L., O’Neill, M.J., Moonen, J., Sarre, S., Smolders, I., Ebinger, G., and Michotte, Y., The effects of LY393613, nimodipine and verapamil, in focal cerebral ischaemia, Eur. J. Pharmacol., 411, 71, 2001.
92. Fabricius, M., Akgoren, N., Dirnagl, U., and Lauritzen, M., Laminar analysis of cerebral blood flow in cortex of rats by laser-Doppler flowmetry: a pilot study, J. Cereb. Blood Flow Metab., 17, 1326, 1997.
93. Skarphedinsson, J.O., Sandberg, M., Hagberg, H., Carlsson, S., and Thoren, P.R., Relative cerebral ischemia in SHR due to hypotensive hemorrhage: cerebral function, blood flow and extracellular levels of lactate and purine catabolites, J. Cereb. Blood Flow Metab., 9, 364, 1989.
94. Holloway, G.A., Cutaneous blood flow responses to injection trauma measured by laser Doppler velocimetry, J. Invest. Dermatol., 74, 1, 1980.
95. Nilsson, G.E., Otto, U., and Wahlberg, J.E., Assessment of skin irritancy in man by laser Doppler flowmetry, Contact Dermatitis, 8, 401, 1982.
96. Engelhart, M. and Kristensen, J.K., Evaluation of cutaneous blood flow responses by 133Xenon washout and a laser-Doppler flowmeter, J. Invest. Dermatol., 80, 12, 1983.
97. Wahlberg, J.E., Skin irritancy from alkaline solutions assessed by laser Doppler flowmetry, Contact Dermatitis, 10, 111, 1984.
98. Wahlberg, J.E. and Wahlberg, E., Patch test irritancy quantified by laser Doppler flowmetry, Contact Dermatitis, 11, 257, 1984.
99. Fischer, J.C., Parker, P.M., and Shaw, W.W., Laser Doppler flowmeter measurements of skin perfusion changes associated with arterial and venous compromise in the cutaneous island flap, Microsurgery, 6, 238, 1985.
100. Astrom, M. and Westlin, N., Blood flow in the human Achilles tendon assessed by laser Doppler flowmetry, J. Orthopaed. Res., 12, 246, 1994.
101. Hellem, S., Jacobsson, L.S., and Nilsson, G.E., Microvascular response in cancellous bone to halothane-induced hypotension in pigs, Int. J. Oral Surg., 12, 178, 1983.
102. Hellem, S., Jacobsson, L.S., Nilsson, G.E., and Lewis, D.H., Measurement of microvascular blood flow in cancellous bone using laser Doppler flowmetry and 133Xe-clearance, Int. J. Oral Surg., 12, 165, 1983.
103. Swiontkowski, M.F., Tepic, S., Perren, S.M., Moor, R., Ganz, R., and Rahn, B.A., Laser Doppler flowmetry for bone blood flow measurement, correlation with microsphere estimates and evaluation of the effect of intracapsular pressure on femoral head blood flow, J. Orthopaed. Res., 4, 362, 1986.
104. Swiontkowski, M.F., Ganz, R., Schlegel, U., and Perren, S.M., Laser Doppler flowmetry for clinical evaluation of femoral head osteonecrosis. Preliminary experience, Clin. Orthopaed. Relat. Res., 218, 181, 1987.
105. Swiontkowski, M.F., Hagan, K., and Shack, R.B., Adjunctive use of laser Doppler flowmetry for debridement of osteomyelitis, J. Orthopaed. Trauma, 3, 1, 1989.
106. Swiontkowski, M.F., Surgical approaches in osteomyelitis. Use of laser Doppler flowmetry to determine nonviable bone, Infect. Dis. Clin. N. Am., 4, 501, 1990.
107. Hobbs, C.M. and Watkins, P.E., Evaluation of the viability of bone fragments, J. Bone Joint Surg., — Br. Vol., 83, 130, 2001.
108. Engelhart, M. and Kristensen, J.K., Raynaud’s phenomenon, blood supply to fingers during indirect cooling, evaluated by laser Doppler flowmetry, Clin. Physiol., 6, 481, 1986.
109. Gush, R.J., Taylor, L.J., and Jayson, M.I., Acute effects of sublingual nifedipine in patients with Raynaud’s phenomenon, J. Cardiovasc. Pharmacol., 9, 628, 1987.
110. Anderson, M.E., Campbell, F., Hollis, S., Moore, T., Jayson, M.I., and Herrick, A.L., Non-invasive assessment of digital vascular reactivity in patients with primary Raynaud’s phenonenon and systemic sclerosis, Clin. Exp. Rheumatol., 17, 49, 1999.
111. Tooke, J.E., Lins, P.E., Östergren, J., and Fagrell, B., Skin microvascular autoregulatory responses in type I diabetes: the influence of duration and control, Int. J. Microcirc. Clin. Exp., 4, 249, 1985.
112. Rayman, G., Williams, S.A., Spencer, P.D., Smaje, L.H., Wise, P.H., and Tooke, J.E., Impaired microvascular hyperaemic response to minor skin trauma in type I diabetes, Br. Med. J. Clin. Res. Ed., 292, 1295, 1986.
113. Westerman, R.A., Widdop, R.E., Hogan, C., and Zimmet, P., Non-invasive tests of neurovascular function, reduced responses in diabetes mellitus, Neurosci. Lett., 81, 177, 1987.
114. Caballero, A.E., Arora, S., Saouaf, R., Lim, S.C., Smakowski, P., Park, J.Y., King, G.L., LoGerfo, F.W., Horton, E.S., and Veves, A., Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes, Diabetes, 48, 1856, 1999.
115. Khan, F., Elhadd, T.A., Greene, S.A., and Belch, J.J., Impaired skin microvascular function in children, adolescents, and young adults with type 1 diabetes, Diabetes Care, 23, 215, 2000.
116. Larrabee, W.F., Jr., G.A. Holloway Jr., R.E. Trachy and D. Sutton, Skin flap tension and wound slough, correlation with laser Doppler velocimetry, Otolaryngol. — Head Neck Surg., 90, 185, 1982.
117. Svensson, H., Svedman, P., Holmberg, J., and Jacobsson, S., Detecting arterial and venous obstruction in flaps, Ann. Plast. Surg., 14, 20, 1985.
118. Svensson, H., Holmberg, J., and Svedman, P., Interpreting laser Doppler recordings from free flaps, Scand. J. Plast. Reconstr. Surg. Hand Surg., 27, 81, 1993.
119. Banic, A., Sigurdsson, G.H., and Wheatley, A.M., Continuous perioperative monitoring of microcirculatory blood flow in pectoralis musculocutaneous flaps, Microsurgery, 16, 469, 1995.
120. Cheng, M.H., H.C. Chen, F.C. Wei, S.W. Su, S.H. Lian and E. Brey, Devices for ischemic preconditioning of the pedicled groin fla, J. Trauma-Injury Infect. Critical Care, 48, 552, 2000.
121. Belcaro, G., Nicolaides, A.N., Laurora, G., Cesarone, M.R., De Sanctis, M.T., Incandela, L., and Labropoulos, N., Laser Doppler flux in normal and arteriosclerotic carotid artery wall, Vasa, 25, 221, 1996.
122. Kvernebo, K., Slasgsvold, C.E., and Stranden, E., Laser Doppler flowmetry in evaluation of skin post-ischaemic reactive hyperaemia. A study in healthy volunteers and atherosclerotic patients, J. Cardiovasc. Surg., 30, 70, 1989.
123. Ghajar, A.W. and Miles, J.B., The differential effect of the level of spinal cord stimulation on patients with advanced peripheral vascular disease in the lower limbs, Br. J. Neurosurg., 12, 402, 1998.
124. Duan, J., Murohara, T., Ikeda, H., Sasaki, K., Shintani, S., Akita, T., Shimada, T., and Imaizumi, T., Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia, Arteriosclerosis, Thrombosis Vasc. Biol., 20, 2579, 2000.
125. Micheels, J., Alsbjorn, B., and Sorensen, B., Clinical use of laser Doppler flowmetry in a burns unit, Scand. J. Plast. Reconstr. Surg., 18, 65, 1984.
126. Alsbjorn, B., Micheels, J., and Sorensen, B., Laser Doppler flowmetry measurements of superficial dermal, deep dermal and subdermal burns, Scand. J. Plast. Reconstr. Surg., 18, 75, 1984.
127. Schiller, W.R., Garren, R.L., Bay, R.C., Ruddell, M.H., Holloway, G.A., Jr., Mohty, A., and Luekens, C.A., Laser Doppler evaluation of burned hands predicts need for surgical grafting, J. Trauma- Injury Infect. Crit. Care, 43, 35, 1997; discussion, 39.
128. Lunde, O.C., Kvernebo, K., and Larsen, S., Evaluation of endoscopic laser Doppler flowmetry for measurement of human gastric blood flow. Methodologic aspects, Scand. J. Gastroenterol., 23, 1072, 1988.
129. Lunde, O.C., Kvernebo, K., and Larsen, S., Effect of pentagastrin and cimetidine on gastric blood flow measured by laser Doppler flowmetry, Scand. J. Gastroenterol., 23, 151, 1988.
130. Lunde, O.C. and Kvernebo, K., Gastric blood flow in patients with gastric ulcer measured by endoscopic laser Doppler flowmetry, Scand. J. Gastroenterol., 23, 546, 1988.
131. Lunde, O.C., Endoscopic laser Doppler flowmetry in evaluation of human gastric blood flow, J. Oslo City Hosp., 38(11), 113, 1988.
132. Krogh-Sorensen, K. and Lunde, O.C., Perfusion of the human distal colon and rectum evaluated with endoscopic laser Doppler flowmetry. Methodologic aspects, Scand. J. Gastroenterol., 28, 104, 1993.
133. Trimarco, B., Lembo, G., DeLuca, N., Ricciardelli, B., Rosiello, G., Volpe, M., Orofino, G., and Condorelli, M., Long-term reduction of peripheral resistance with celiprolol and effects on left ventricular mass, J. Int. Med. Res., 16(Suppl 1), 62A, 1988.
134. Iabichella, M.L., Dell’Omo, G., Melillo, E., and Pedrinelli, R., Calcium channel blockers blunt postural cutaneous vasoconstriction in hypertensive patients, Hypertension, 29, 751, 1997.
135. Mustakallio, K.K. and Kolari, P.J., Irritation and staining by dithranol (anthralin) and related compounds. IV. Visual estimation of erythema compared with contact thermometry and laser Doppler flowmetry, Acta Dermato-Venereol., 63, 513, 1983.
136. Fullerton, A., Avnstorp, C., Agner, T., Dahl, J.C., Olsen, L.O., and Serup, J., Patch test study with calcipotriol ointment in different patient groups, including psoriatic patients with and without adverse dermatitis, Acta Dermato-Venereol., 76, 194, 19962.
137. Hammarlund, A., Olsson, P., and Pipkorn, U., Blood flow in dermal allergen-induced immediate and late-phase reactions, Clin. Exp. Allergy, 19, 197, 19892.
138. Moor Instruments, L., reference list, http,//www.moor.co.uk, 2001, Moor Instruments Ltd.
139. Perimed, A., reference list, http,//www.perimed.se, 2001, Perimed AB.
140. Fullerton, A., Benfeldt, E., Petersen, J.R., Jensen, S.B., and Serup, J., The calcipotriol dose-irritation relationship, 48 hour occlusive testing in healthy volunteers using Finn Chambers, Br. J. Dermatol., 138, 259, 1998.
141. Issachar, N., Gall, Y., Borrel, M.T., and Poelman, M.C., Correlation between percutaneous penetration of methyl nicotinate and sensitive skin, using laser Doppler imaging, Contact Dermatitis, 39, 182, 1998.
142. Bjarnason, B. and Fischer, T., Objective assessment of nickel sulfate patch test reactions with laser Doppler perfusion imaging, Contact Dermatitis, 39, 112, 1998.
143. Fischer, T., Dahlen, A., and Bjarnason, B., Influence of patch-test application tape on reactions to sodium dodecyl sulfate, Contact Dermatitis, 40, 32, 1999.
144. Bjarnason, B., Flosadottir, E., and Fischer, T., Assessment of budesonide patch tests, Contact Dermatitis, 41, 211, 1999.
145. Fullerton, A. and Serup, J., Laser doppler image scanning for assessment of skin irritation, in Irritant Dermatitis. New Clinical and Experimental Aspects. Current Problems in Dermatology, Burg, G., Ed., Zurich, 1995, p. 159.
146. Wang, I., Andersson-Engels, S., Nilsson, G.E., Wårdell, K., and Svanberg, K., Superficial blood flow following photodynamic therapy of malignant non-melanoma skin tumours measured by laser Doppler perfusion imaging, Br. J. Dermatol., 136, 184, 1997.
147. Stücker, M., Horstmann, I., Nuchel, C., Rochling, A., Hoffmann, K., and Altmeyer, P., Blood flow compared in benign melanocytic naevi, malignant melanomas and basal cell carcinomas, Clin. Exp. Dermatol., 24, 107, 1999.
148. Enejder, A.M., af Klinteberg, C., Wang, I., Andersson-Engels, S., Bendsoe, N., Svanberg, S., and Svanberg, K., Blood perfusion studies on basal cell carcinomas in conjunction with photodynamic therapy and cryotherapy employing laser-Doppler perfusion imaging, Acta Derm. Venereol., 80, 19, 2000.
149. Kloppenberg, F.W., Beerthuizen, G.I., and ten Duis, H.J., Perfusion of burn wounds assessed by laser doppler imaging is related to burn depth and healing time, Burns, 27, 359, 2001.
150. Droog, E.J., Steenbergen, W., and Sjöberg, F., Measurement of depth of burns by laser Doppler perfusion imaging, Burns, 27, 561, 2001.
151. Gschwandtner, M.E., Ambrozy, E., Fasching, S., Willfort, A., Schneider, B., Bohler, K., Gaggl, U., and Ehringer, H., Microcirculation in venous ulcers and the surrounding skin, findings with capillary microscopy and a laser Doppler imager, Eur. J. Clin. Invest., 29, 708, 1999.
152. Gschwandtner, M.E., Ambrozy, E., Maric, S., Willfort, A., Schneider, B., Böhler, K., Gaggl, U., and Ehringer, H., Microcirculation is similar in ischemic and venous ulcers, Microvasc. Res., 62, 226, 20015.
153. Mayrovitz, H.N., Smith, J., and Delgado, M., Variability in skin microvascular vasodilatory responses assessed by laser-Doppler imaging, Ostomy Wound Manage., 43, 66, 1997.
154. Mayrovitz, H.N., Smith, J., Delgado, M., and Regan, M.B., Heel blood perfusion responses to pressure loading and unloading in women, Ostomy Wound Manage., 43, 16, 1997.
155. Mayrovitz, H.N. and Smith, J., Heel-skin microvascular blood perfusion responses to sustained pressure loading and unloading, Microcirculation, 5, 227, 1998.
156. Mayrovitz, H.N., Macdonald, J., and Smith, J.R., Blood perfusion hyperaemia in response to graded loading of human heels assessed by laser-Doppler imaging, Clin. Physiol., 19, 351, 1999.
157. Bornmyr, S., Svensson, H., Lilja, B., and Sundkvist, G., Cutaneous vasomotor responses in young type I diabetic patients, J. Diabetes Complications, 11, 21, 1997.
158. Morris, S.J., Shore, A.C., and Tooke, J.E., Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM, Diabetologia, 38, 1337, 1995.
159. Algotsson, A., Nordberg, A., Almkvist, O., and Winblad, B., Skin vessel reactivity is impaired in Alzheimer’s disease, Neurobiol. Aging, 16, 577, 1995.
160. Couffinhal, T., Silver, M., Zheng, L., Kearney, M., Witzenbichler, B., and Isner, J.M., Mouse model of angiogenesis, Am. J. Pathol., 152, 1667, 1998.
161. Rivard, A., Fabre, J.E., Silver, M., Chen, D., Murohara, T., Kearney, M., Magner, M., Asahara, T., and Isner, J.M., Age-dependent impairment of angiogenesis, Circulation, 99, 111, 1999.
162. Krogstad, A.L., Swanbeck, G., and Wallin, B.G., Axon-reflex-mediated vasodilatation in the psoriatic plaque? J. Invest. Dermatol., 104, 872, 1995.
163. Krogstad, A.L., Lonnroth, P., Larson, G., and Wallin, B.G., Capsaicin treatment induces histamine release and perfusion changes in psoriatic skin, Br. J. Dermatol., 141, 87, 1999.
164. Aghassi, D., Monoson, T., and Braverman, I., Reproducible measurements to quantify cutaneous involvement in scleroderma, Arch. Dermatol., 131, 1160, 1995.
165. Picart, C., Carpentier, P.H., Brasseur, S., Galliard, H., and Piau, J.M., Systemic sclerosis, blood rheometry and laser Doppler imaging of digital cutaneous microcirculation during local cold exposure, Clin. Hemorheol. Microcirc., 18, 47, 1998.
166. Eichhorn, W., Auer, T., Voy, E.D., and Hoffmann, K., Laser Doppler imaging of axial and random pattern flaps in the maxillo-facial area. A preliminary report, J. Cranio-Maxillo-Facial Surg., 22, 301, 1994.
167. Anderson, C., Andersson, T., and Wårdell, K., Changes in skin circulation after insertion of a microdialysis probe visualized by laser Doppler perfusion imaging, J. Invest. Dermatol., 102, 807, 1994.
168. Ilias, M.A., Wårdell, K., Falk, M. and Anderson, C., Phototesting based on a divergent beam — a study on normal subjects, Photodermatol. Photoimmunol. Photomed., 17, 189, 2001.