Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 804, Issue 2, 2004, Pages 303-311

  Hedeland, Mikael ^a   Fredriksson, Elisabeth ^a   Lennernäs, Hans ^b   Bondesson, Ulf ^a,b  

^a NATIONAL VETERINARY INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Enantiomer separation; Norverapamil; Verapamil

Indexed keywords

ACETONITRILE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

BIOAVAILABILITY; ELECTROSPRAY INTERFACE;

BIOMEDICAL ENGINEERING;

ACETONITRILE; AMMONIUM ACETATE; DRUG METABOLITE; NORVERAPAMIL; VERAPAMIL;

ADULT; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; LIQUID CHROMATOGRAPHY; MALE; MOLECULAR WEIGHT; NORMAL HUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; TANDEM MASS SPECTROMETRY;

BIOLOGICAL AVAILABILITY; CALCIUM CHANNEL BLOCKERS; HUMANS; INTESTINAL ABSORPTION; MASS SPECTROMETRY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; VERAPAMIL;

EID: 1842734238     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2004.01.026     Document Type: Article

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