Stereoselective metabolism of two keto-pyrrol analogues of 8-hydroxy-2- dipropyl-aminotetralin by freshly isolated rat hepatocytes

Chirality

Volumn 8, Issue 3, 1996, Pages 264-270

  Wood, S A ^a   Parton, A H ^b   Simmonds, R J ^a   Stevenson, D ^c  

^a Upjohn Laboratories Europe   (United Kingdom)

^b UCB PHARMA   (Belgium)

^c UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

drug development; enantiomers; HPLC; In vitro metabolism; mass spectrometry

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CHIRALITY; DRUG METABOLISM; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; LIVER CELL; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIVER; MASS SPECTROMETRY; RATS; SEROTONIN AGONISTS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0029759299     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1996)8:3<264::AID-CHIR6>3.0.CO;2-H     Document Type: Article

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