Growth arrest and apoptosis of human hepatocellular carcinoma cells induced by hexamethylene bisacetamide

World Journal of Gastroenterology

Volumn 10, Issue 7, 2004, Pages 954-958

  Ouyang, Gao Liang ^a   Cai, Qui Feng ^a   Liu, Min ^a   Chen, Rui Chuan ^a   Huang, Zhi ^a   Jiang, Rui Sheng ^a   Chen, Fu ^a   Hong, Shui Gen ^a   Bao, Shi Deng ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; HEXAMETHYLENEBISACETAMIDE; INHIBITOR OF APOPTOSIS PROTEIN; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CELL ASSAY; CELL CYCLE G1 PHASE; CELL NUCLEUS; CELL POPULATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; ISOTOPE LABELING; LIVER CELL CARCINOMA; PHASE CONTRAST MICROSCOPY; PROTEIN EXPRESSION; UPREGULATION;

EID: 1842686822     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v10.i7.954     Document Type: Article

References (43)

1. Varela M, Sala M, Llovet JM, Bruix J. Treatment of hepatocellular carcinoma: Is there an optimal strategy? Cancer Treat Rev 2003; 29: 99-104
2. Kew MC. Epidemiology of hepatocellular carcinoma. Toxicology 2002; 181-182: 35-38
3. Chen CJ, Yu MW, Liaw YF. Epidemiological characteristics and risk factors of hepatocellular carcinoma. J Gastroenterol Hepatol 1997; 12: S294-308
4. Wu MC. Clinical research advances in primary liver cancer. World J Gastroenterol 1998; 4: 471-474
5. Zeng ZC, Jiang GL, Wang GM, Tang ZY, Curran WJ, Iliakis G. DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line. World J Gastroenterol 2002; 8: 797-803
6. Yu MC, Yuan JM, Govindarajan S, Ross RK. Epidemiology of hepatocellular carcinoma. Can J Gastroenterol 2000; 14: 703-709
7. Herrero R, Moncelli MR, Guidelli R, Carla M, Arcangeli A, Olivotto M. Hybrid polar compounds produce a positive shift in the surface dipole potential of self-assembled phospholipid monolayers. Biochim Biophys Acta 2000; 1466: 278-288
8. Rifkind RA, Richon VM, Marks PA. Induced differentiation, the cell cycle, and the treatment of cancer. Pharmacol Ther 1996; 69: 97-102
9. Leszczyniecka M, Roberts T, Dent P, Grant S, Fisher PB. Differentiation therapy of human cancer: Basic science and clinical applications. Pharmacol Ther 2001; 90: 105-156
10. Guilbaud NF, Gas N, Dupont MA, Valette A. Effects of differentiation-inducing agents on maturation of human MCF-7 breast cancer cells. J Cell Physiol 1990; 145: 162-172
11. Marks PA, Richon VM, Kiyokawa H, Rifkind RA. Inducing differentiation of transformed cells with hybrid polar compounds: A cell cycle-dependent process. Proc Natl Acad Sci U S A 1994; 91: 10251-10254
12. Li XN, Du ZW, Huang Q. Modulation effects of hexamethylene bisacetamide on growth and differentiation of cultured human malignant glioma cells. J Neurosurg 1996; 84: 831-838
13. Ouyang GL, Li QF, Peng XX, Hong SG. Differentiation of human hepatocarcinoma SMMC-7721 cells induced by HMBA. Shiyan Shengwu Xuebao 2001; 34: 269-273
14. Ouyang GL, Li QF, Peng XX, Hong SG. Effects of HMBA on the expression of cell-cycle-associated genes in human hepatocarcinoma SMMC-7721 cells. Shiyan Shengwu Xuebao 2002; 35: 173-178
15. Ren JG, Zheng RL, Shi YM, Gong B, Li JF. Apoptosis, redifferentiation and arresting proliferation simultaneously triggered by oxidative stress in human hepatoma cells. Cell Biol Int 1998; 22: 41-49
16. Li J, Huang CY, Zheng RL, Cui KR, Li JF. Hydrogen peroxide induces apoptosis in human hepatoma cells and alters cell redox status. Cell Biol Int 2000; 24: 9-23
17. Yuan JH, Wang XW, Luo D, Xie Y, Xie H. Anti-hepatoma activity of taxol in vitro. Acta Pharmacol Sin 2000; 21: 450-454
18. Zhang SW, Lin WS, Ying XL, Zhu D, Guo MY, Gu JX. Effect of suppression of TGF-β1 expression on cell-cycle and gene expression of β-1, 4-galactosyltransferase 1 in human hepatocarcinoma cells. Biochem Biophys Res Commun 2000; 273: 833-838
19. Chan EW, Cheng SC, Sin FW, Xie Y. Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines. Toxicol Lett 2001; 122: 81-87
20. Ouyang GL, Li QF, Peng XX, Liu QR, Hong SG. Effects of tachyplesin on proliferation and differentiation of human hepatocellular carcinoma SMMC-7721 cells. World J Gastroenterol 2002; 8: 1053-1058
21. Chen RC, Su JH, Ouyang GL, Cai KX, Li JQ, Xie XG. Induction of differentiation in human hepatocarcinoma cells by isoverbascoside. Planta Med 2002; 68: 370-372
22. Geng CX, Zeng ZC, Wang JY. Docetaxel inhibits SMMC-7721 human hepatocellular carcinoma cells growth and induces apoptosis. World J Gastroenterol 2003; 9: 696-700
23. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70
24. Siegel DS, Zhang X, Feinman R, Teitz T, Zelenetz A, Richon VM, Rifkind RA, Marks PA, Michaeli J. Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells. Proc Natl Acad Sci U S A 1998: 95: 162-166
25. Hyman T, Rothmann C, Heller A, Malik Z, Salzberg S. Structural characterization of erythroid and megakaryocytic differentiation in Friend erythroleukernia cells. Exp Hematol 2001; 29: 563-571
26. Shelly LL, Fuchs C, Miele L. Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds. J Cell Biochem 1999; 73: 164-175
27. Ruefli AA, Smyth MJ, Johnstone RW. HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance. Blood 2000; 95: 2378-2385
28. Zhang Z, Liong EC, Lau TY, Leung KM, Fung PC, Tipoe GL. Induction of apoptosis by hexamehtylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation. Int J Oncol 2000; 16: 887-892
29. Liu JR, Chen BQ, Yang YM, Wang XL, Xue YB, Zheng YM, Liu RH. Effect of apoptosis on gastric adenocarcinoma cell line SGC-7901 induced by cis-9, trans-11-conjugated linoleic acid. World J Gastroenterol 2002; 8: 999-1004
30. Kroemer G, Dallaporta B, Resche-Rigon M. The mithochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998; 60: 619-642
31. Chao DT, Korsmeyer SJ. BCL-2 family: Regulators of cell death. Annu Rev Immunol 1998; 16: 395-419
32. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome C from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136
33. Evan G, Littlewood T. A matter of life and cell death. Science 1998; 281: 1317-1322
34. Kobayashi T, Ruan S, Clodi K, Kliche KO, Shiku H, Andreeff M, Zhang W. Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents. Oncogene 1998; 16: 1587-1591
35. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619
36. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dimers foil death wishes. Cell 1994; 79: 189-192
37. Reed JC. Bcl-2 family proteins. Oncogene 1998; 17: 3225-3236
38. Fukamachi Y, Karasaki Y, Sugiura T, Itoh H, Abe T, Yamamura K, Higashi K. Zinc suppresses apoptosis of U937 cells induced by hydrogen peroxide through an increase of the Bcl-2/Bax ratio. Biochem Biophys Res Commun 1998; 246: 364-369
39. Panaretakis T, Pokrovskaja K, Shoshan MC, Grander D. Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax. Oncogene 2003; 22: 4543-4556
40. Yan J, Xu YH. Tributyrin inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. World J Gastroenterol 2003; 9: 660-664
41. Zhou HB, Zhu JR. Paclitaxel induces apoptosis in human gastric carcinoma cells. World J Gastroenterol 2003; 9: 442-445
42. Aranha O, Grignon R, Fernandes N, McDonnell TJ, Wood DP Jr, Sarkar FH. Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis. Int J Oncol 2003; 22: 787-794
43. Pettersson F, Dalgleish AG, Bissonnette RP, Colston KW. Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. Br J Cancer 2002; 87: 555-561