Anti-hepatoma activity of taxol in vitro

Acta Pharmacologica Sinica

Volumn 21, Issue 5, 2000, Pages 450-454

  Yuan, Jin Hui ^a   Wang, Xing Wang ^a   Luo, Dan ^b   Xie, Yong ^b   Xie, Hong ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Apoptosis; Cell cycle; Cell division; Cultured tumor cells; Hepatocellular carcinoma; Taxol

Indexed keywords

PACLITAXEL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL GROWTH; CELL KINETICS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; MITOSIS INHIBITION;

EID: 0034084904     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Schiff PB, Fant J, Horwitz SB. Promotion of microtubules assembly in vitro by taxol. Nature 1979; 22: 665-7.
2. Rowiasky EK, Donehower RC. Taxol: twenty years later, the story unfolds. J Natl Cancer Inst 1991; 83: 1778-81.
3. Lui WY, Chang YF, Li LL, Ho LK, Su TL, Chen JY, et al. Differential paclitaxel-induced cytotoxicity in rodent and human hepatoma cell lines. Anticancer Res 1998; 18: 3339-45.
4. Seong J, Milross CG, Hunter MR, Shin HC, Milas L. Potentiation of antitumor efficacy of paclitaxel by recombinant tumor necrosis factor-alpha. Anticancer Drugs 1997; 8: 80-7.
5. Strumberg D, Erhard J, Harstrick A, Klaassen U, Muller C, Eberhardt W, et al. Phase I study of a weekly 1 h infusion of paclitaxel in patients with unresectable hepatocellular carcinoma. EUT J Cancer 1998; 34: 1290-2.
6. Chao Y, Chan WK, Birkhofer MI, Hu OY, Wang SS, Huang YS, et al. Phase II and pharmacokinetic study of paclitaxel therapy for unresectable hepatocellular carcinoma patients. Br J Cancer 1998; 78: 34-9.
7. Dong RC. Establishment of human hepatocarcinoma cell line SMMC-7721 and initial observations on its biologic characteristics. In: Tang ZY, Wu MC, XiaSS, editors. Primary liver cancer. Beijing: China Academic Publishers; 1989. p 145-53.
8. Mosmann T. Rapid colorimetric assay for cellular growth and survival : application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
9. cdc2 inactivation and mitotic exit in mammalian cells. J Cell Biol 1991; 127: 789-802.
10. Gagandeep S, Novikoff PM, Ort M, Gupta S. Paclitaxel shows cytotoxic activity in human hepatocellular carcinoma cell lines. Cancer Lett 1999; 136: 109-18.
11. Johnson SW, Shen D, Pastan I, Gottesman MM, Hamilton TC. Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and resistant human hepatoma cell lines. Exp Cell Res 1996; 226: 133-9.
12. Torres K, Horwitz SB. Mechanisms of taxol-induced cell death are concentration dependent. Cancer Res 1998; 58: 3620-6.
13. Lanni JS, Lowe SW, Ucitra EJ, Liu JO, Jacks T. p53-independent apoptosis induced by paclitaxel through an indirect mechanism. Proc Natl Acad USA 1997; 94: 9679-83.
14. Danesi R, Figg WD, Reed E, Myers CE. Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells. Mol Pharmacol 1995; 47: 1106-11.
15. 2/M cell cycle arrest. Br J Cancer 1998; 77: 404-11.
16. cdc2 activation required for apoptosis . Science 1994; 263: 1143-5.
17. Milross CG, Mason KA, Hunter MR, Chung WK, Peters LJ, Milas L. Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel. J Natl Cancer Inst 1996; 88: 1308-14.
18. cdc2 coincident with taxol-induced apoptosis. Cell Growth Differ 1991; 5: 1041-50.
19. Ling YH, Consoli U, Tomos C, Andreeff M, Perez-Soler R. Accumulation of cyclin Bl, activation of cyclin Bl-dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol. Int J Cancer 1998; 75: 925-32.
20. Oberhammer F, Bursch W, Tiefenbacher R, Froschl G, Pavelka M, Purchio T, et al. Apoptosis is induced by transforming growth factor-β1 within 5 hours in regressing liver without significant fragmentation of the DNA. Hepatology 1993; 18: 1238-46.
21. Rudner AD, Murray AW. The spindle assembly checkpoint. Curr Opin Cell Biol 1996; 8: 773-80.
22. Zaffaroni N, Silvestrini R, Orlandi L, Bearzatto A, Gornati D, Villa R. Induction of apoptosis by taxol and cisplatin, and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cancer cells. Br J Cancer 1998; 77: 1378-85.
23. cdc2 kinase. Mol Cell 1998; 2: 581-91.