Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass

European Journal of Cardio-thoracic Surgery

Volumn 25, Issue 5, 2004, Pages 825-832

  Szabó, Gábor ^a,b   Soós, Pál ^b   Bährle, Susanne ^a   Zsengellér, Zsuzsanna ^c   Flechtenmacher, Christa ^a   Hagl, Siegfried ^a   Szabó, Csaba ^b,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^c INOTEK CORPORATION   (United States)

Author keywords

Cardiopulmonary bypass; Endothelial function; PARP inhibition; Reperfusion injury

Indexed keywords

ACETYLCHOLINE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITROPRUSSIDE SODIUM;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOPULMONARY ARREST; CARDIOPULMONARY BYPASS; CATHETER; CONDUCTANCE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORRELATION ANALYSIS; DOG; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ASSAY; HEART ARREST; HEART MUSCLE REPERFUSION; HEART VENTRICLE; HYPOTHERMIA; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; LUNG ALVEOLUS OXYGEN TENSION; LUNG BLOOD FLOW; LUNG FUNCTION; NONHUMAN; PATHOGENESIS; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SYSTOLE; VASODILATATION;

ANIMALS; CARDIOPULMONARY BYPASS; CORONARY VESSELS; DISEASE MODELS, ANIMAL; DOGS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; HEART ARREST, INDUCED; HEMODYNAMIC PROCESSES; LUNG; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; POLY(ADP-RIBOSE) POLYMERASES; VASODILATION;

EID: 1842634661     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2004.01.031     Document Type: Article

References (23)

1. Virág L., Szabó C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 54:2002;375-429.
2. Zingarelli B., Salzman A.L., Szabó C. Genetic disruption of poly(ADP-ribose) synthetase inhibits the expression of P-selectin and intracellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res. 83:1998;85-97.
3. Bowes J., McDonald M.C., Piper J., Thiemermann C. Inhibitors of poly(ADP-ribose) synthetase protects rat cardiomyocytes against oxidant stress. Cardiovasc Res. 41:1999;126-134.
4. Zingarelli B., Cuzzocrea S., Zsengellér Z., Salzman A.L., Szabó C. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly(ADP ribose) synthetase. Cardiovasc Res. 36:1997;205-215.
5. Szabó G., Bährle S., Stumpf N., Sonnenberg K., Szabo E.E., Pacher P., Csont T., Schulz R., Dengler T.J., Liaudet L., Jagtap P.G., Southan G.J., Vahl C.F., Hagl S., Szabo C. Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation. Circ Res. 90:2002;100-106.
6. Wallace A., Lam H.W., Nose P.S., Bellows W., Mangano D.T. Changes in systolic and diastolic ventricular function with cold cardioplegic arrest in man. The Multicenter Study of Perioperative Ischemia (McSPI) Research Group. J Card Surg. 9:(3):1994;497-502.
7. Wan S., LeClerc J.L., Vincent J.L. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest. 112:1997;676-692.
8. Andrási T.B., Buhmann V., Soós P., Juhász-Nagy A., Szabó G. Mesenteric complications after hypothermic cardiopulmonary bypass with cardiac arrest: underlying mechanisms. Artif Organs. 26:2002;943-946.
9. Ng C.S., Wan S., Yim A.P., Arifi A.A. Pulmonary dysfunction after cardiac surgery. Chest. 121:2002;1269-1277.
10. Jagtap P., Soriano F.G., Virág L., Liaudet L., Mabley J., Szabo E., Hasko G., Marton A., Lorigados C.B., Gallyas F. Jr, Sumegi B., Hoyt D.G., Baloglu E., VanDuzer J., Salzman A.L., Southan G.J., Szabo C. Novel phenathridinone inhibitors of poly(ADP-ribose) synthetase: potent cytoprotective and anti-shock agents. Crit Care Med. 30:2002;1071-1082.
11. Soriano F.G., Virág L., Jagtap P., Szabo E., Mabley J.G., Liaudet L., Marton A., Hoyt D.G., Murthy K.G., Salzman A.L., Southan G.J., Szabo C. Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 7:2001;108-113.
12. Szabó G., Bährle S., Bátkai S., Stumpf N., Dengler T.J., Zimmermann R., Vahl C.F., Hagl S. L-arginine: effect on reperfusion injury after heart transplantation. World J Surg. 22:1998;791-798.
13. Grupp I.L., Jackson T.M., Hake P., Grupp G., Szabó C. Protection against hypoxia-reoxygenation in the absence of poly(ADP-ribose) synthetase in isolated working hearts. J Mol Cell Cardiol. 31:1999;297-303.
14. Thiemermann C., Bowes J., Myint F.P., Vane J.R. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci USA. 94:1997;679-683.
15. Liaudet L., Szabó G., Szabó C. Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite-poly(ADP-ribose) polymerase connection. Coron Artery Dis. 14:2003;115-122.
16. Cameron D. Initiation of white cell activation during cardiopulmonary bypass: cytokines and receptors. J Cardiovasc Pharmacol. 27:(Suppl 1):1996;S1-S5.
17. Morse D.S., Adams D., Magnani B. Platelet and neutrophil activation during cardiac surgical procedures: impact of cardiopulmonary bypass. Ann Thorac. 65:1998;691-695.
18. Massoudy P., Zahler S., Becker B.F., Braun S.L., Barankay A., Meissner H. Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass. Chest. 119:2001;31-36.
19. Schlensak C., Doenst T., Preußer S., Wunderlich M., Kleinschmidt M., Beyersdorf F. Cardiopulmonary bypass reduction of bronchial blood flow: a potential mechanism for lung injury in a neonatal pig model. J Thorac Cardiovasc Surg. 123:2002;1199-1205.
20. Kim W.G., Lee B.H., Seo J.W. Light and electron microscopic analyses for ischaemia-reperfusion lung injury in an ovine cardiopulmonary bypass model. Perfusion. 16:2001;207-214.
21. Cuzzocrea S., McDonald M.C., Mazzon E., Dugo L., Serraino I., Threadgill M., Caputi A.P., Thiemermann C. Effects of 5-aminoisoquinolinone, a water soluble, potent inhibitor of the activity of poly(ADP-ribose) polymerase, in a rodent model of lung injury. Biochem Pharmacol. 63:2002;293-304.
22. Liaudet L., Pacher P., Mabley J.G., Virag L., Soriano F.G., Hasko G., Szabo C. Activation of poly(ADP-ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation. Am J Respir Crit Care Med. 165:2002;372-377.
23. Hudak B.B., Tufariello J., Sokolowski J., Maloney C., Holm B.A. Inhibition of poly(ADP-ribose) polymerase preserves surfactant synthesis after hydrogen peroxide exposure. Am J Physiol. 269:1995;L59-L64.