Phosphatase inhibitors induce defective hormone secretion in insulin-secreting cells and entry into apoptosis

Experimental and Clinical Endocrinology and Diabetes

Volumn 107, Issue 1, 1999, Pages 29-34

  Krautheim, A ^a   Rustenbeck, I ^b   Steinfelder, H J ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Apoptosis; Calyculin A; Insulin secretion; Okadaic acid; Ser thr phosphatase inhibitors

Indexed keywords

CALCIUM ION; DNA FRAGMENT; ENZYME INHIBITOR; FORSKOLIN; INSULIN; OKADAIC ACID; PHOSPHATASE; POTASSIUM ION;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; HORMONE RELEASE; INSULIN RELEASE; LONG TERM EXPOSURE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; STIMULUS SECRETION COUPLING;

EID: 0033031287     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1212069     Document Type: Article

References (26)

1. Ämmälä C, Eliasson L, Bokvist K, Berggren PO, Honkanen RE, Sjöholm A, Rorsman P: Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells. Proc Natl Acad Sci U S A 91: 4343 - 4347, 1994
2. Ammon HP, Heurich RO, Kolb HA, Lang F, Schaich R, Drews G, Leiers T: The phosphatase inhibitor okadaic acid blocks KCl-depolarization-induced rise of cytosolic calcium of rat insulinoma cells (RINm5F). Naunyn Schmiedeberg's Arch Pharmacol 354: 95 - 101, 1996
3. Ashcroft SJ: Protein phosphorylation and beta-cell function. Diabetologia 37 Suppl 2: S21 - 29, 1994
4. Darzynkiewicz Z, Li X, Gong J: Assays of cell viability: discrimination of cells dying by apoptosis Methods. Cell Biol 41: 15 - 38, 1994
5. Erecinska M, Bryla J, Michalik M, Meglasson MD, Nelson D: Energy metabolism in islets of Langerhans. Biochim Biophys Acta 1101: 273 - 295, 1992
6. 2+ channels in insulin-secreting cells. Biochem J 298: 341 - 346, 1994
7. Honkanen RE, Codispoti BA, Tse K, Boynton AL: Characterization of natural toxins with inhibitory activity against serine/ threonine protein phosphatases. Toxicon 32: 339-350, 1994
8. Howell SL, Jones PM, Persaud SJ: Regulation of insulin secretion: the role of second messengers. Diabetologia 37 Suppl 2: S30 - 35, 1994
9. Ishihara H, Martin BL, Brautigan DL, Karaki H, Ozaki H, Kato Y, Fusetani N, Watabe S, Hashimoto K, Uemura D: Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun 159: 871 - 877, 1989
10. Janjic D, Wollheim CB: Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia 35: 482 - 485, 1992
11. Joost HG: Effects of possible beta-cell membrane label, metahexamide-isothiocyanate, on insulin release. Horm Metab Res 11: 104 - 106, 1979
12. Marinovich M, Viviani B, Corsini E, Ghilardi F, Galli CL: NFκB activation by triphenyltin triggers apoptosis in HL-60 cells. Exp Cell Res 226: 98-104, 1996
13. Mayer P, Jochum C, Schatz H, Pfeiffer A: Okadaic acid indicates a major function for protein phosphatases in stimulus-response coupling of RINm5F rat insulinoma cells. Exp Clin Endocrinol 102: 313 - 319, 1994
14. Meikrantz W, Schlegel R: Apoptosis and the cell cycle. J Cell Biochem 58: 160 - 174, 1995
15. Nam KY, Hiro M, Kimura S, Fujiki H, Imanishi Y: Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane. Carcinogenesis 11: 1171 - 1174, 1990
16. Namboodiripad AN, Jennings ML: Permeability characteristics of erythrocyte membrane to okadaic acid and calyculin A. Am J Physiol 270: C449 - C456, 1996
17. Ogino K, Inukai T, Miura Y, Matsui H, Takemura Y: Triphenyltin chloride induces glucose tolerance by suppression of insulin release from hamster pancreatic beta-cells. Exp Clin Endocrinol Diabetes 104: 409 - 411, 1996
18. Panten U, Ishida H, Schauder P, Frerichs H, Hasselblatt A: A versatile microperifusion system. Anal Biochem 82: 317 - 326, 1977
19. Ratcliff H, Jones PM: Effects of okadaic acid on insulin secretion from rat islets of Langerhans. Biochim Biophys Acta 1175: 188 - 191, 1993
20. Rustenbeck I, Herrmann C, Grimmsmann T: Energetic requirement of insulin secretion distal to calcium influx. Diabetes 48: 1305 - 1311, 1997
21. 2+ signal in pancreatic beta cells and inhibition of insulin secretion. Br J Pharmacol 123: 97 - 105, 1998
22. Schmidt KN, Traenckner EB, Meier B, Baeuerle PA: Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-κB. J Biol Chem 270: 27136 - 27142, 1995
23. Tamagawa T, Iguchi A, Uemura K, Miura H, Nonogaki K, Ishiguro T, Sakamoto N: Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on insulin release from rat pancreatic islets. Endocrinol Jpn 39: 325 - 329, 1992
24. 3 cells. Naunyn-Schmiedeberg's Arch Pharmacol 356: 8 - 16, 1997
25. Tiedge M, Lortz S, Drinkgern J, Lenzen S: Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46: 1733 - 1742, 1997
26. Zamzami N, Hirsch T, Dallaporta B, Petit PX, Kroemer G: Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomembr 29: 185 - 193, 1997