Immune reconstitution and viral stimulation are required to restore HIV-specific CD8 T cell responses following advanced infection

Journal of Clinical Immunology

Volumn 24, Issue 2, 2004, Pages 115-124

  Gamberg, Jane ^a   Barrett, Lisa ^a   Bowmer, Ian ^a,b   Howley, Constance ^b   Grant, Michael ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b Health Care Corporation of St John's   (Canada)

Author keywords

Cytotoxic T lymphocytes; HAART; HIV; Immune reconstitution

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON;

ADULT; ARTICLE; CASE REPORT; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; HELPER CELL; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; MEMORY CELL; PRIORITY JOURNAL; VIRUS REPLICATION;

ADULT; ANTI-HIV AGENTS; ANTIGENS, CD28; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; FOLLOW-UP STUDIES; HIV CORE PROTEIN P24; HIV INFECTIONS; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RNA, VIRAL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 1842607725     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOCI.0000019776.38147.e6     Document Type: Article

References (36)

1. + lymphocytes. Science 283:857-860, 1999
2. + T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 189:991-998, 1999
3. Gamberg J, Grant M: Cytotoxic T lymphocytes in human immunodeficiency virus type-1 infection. Important or impotent? Clin Appl Immunol Rev 1:17-36, 2000
4. Lieberman J, Shankar P, Manjunath N, Andersson J: Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood 98:1667-1677, 2001
5. Johnson RP, Trocha A, Yang L, Mazzara GP, Panicali DL, Buchanan TM, Walker BD: HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes: Fine specificity of the gag-specific response by using unstimulated peripheral blood mononuclear cells and cloned effector cells. J Immunol 147:1512-1521, 1991
6. Lamhamedi-Cherradi S, Culmann-Penciolelli B, Guy B, Kieny MP, Dreyfus F, Saimot AG, Sereni D, Sicard D, Levy JP, Gomard E: Qualitative and quantitative analysis of human cytolytic T lymphocyte responses to HIV-1 proteins. AIDS 6:1249-1258, 1992
7. Gamberg J, Bowmer M, Trahey J, Campbell C, Pardoe I, Grant M: Functional and genetic integrity of the CD8 T-cell repertoire in advanced HIV infection. AIDS 13:2043-2053, 1999
8. Carmichael A, Jin X, Sissons P, Borysiewicz L: Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: Differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J Exp Med 177:249-256, 1993
9. Rosenberg E, Billingsley J, Caliendo A, Boswell SL, Sax PE, Kalams SA, Walker BD: Vigorous HIV-1-speciiic CD4+ T cell responses associated with control of viremia. Science 278:1447-1450, 1997
10. Pitcher CJ, Quittner C, Peterson DM, Connors M, Koup RA, Maino VC, Picker LJ: HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat Med 5:518-525, 1999
11. Wolthers K, Miedema F: Telomeres and HIV infection: In search of exhaustion. Trends Microbiol 6:144-147, 1998
12. Effros RB, Allsopp R, Chiu CP, Hausner MA, Hirji K, Wang L, Harley CB, Villeponteau B, West MD, Giorgi JV: Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10:F17-F22, 1996
13. Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infections. N Engl J Med 338:853-860, 1998.
14. Li TS, Tubiana R, Katlama C, Calvez V, Mohand HA, Autran B: Long-lasting recovery in CD4 T cell function and viral load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet 351:1682-1686, 1998
15. + T cell homeostasis and function in advanced HIV disease. Science 277:112-116, 1997
16. Rinaldo CR Jr, Huang XL, Fan Z, Margolick JB, Borowski L, Hoji A, Kalinyak C, McMahon DK, Riddler SA, Hildebrand WH, Day RB, Mellors JW: Anti-Human Immunodeficiency Virus type 1 (HIV-1) CD8+ T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1-infected patients with advanced immunodeficiency. J Virol 74:4127-4138, 2000
17. Landay AL, Bettendorf D, Chan E, Spritzler J, Schmitz JL, Bucy RP, Gonzalez CJ, Schnizlein-Bick CT, Evans T, Squires KE, Phair JP: Evidence of immune reconstitiution in antiretroviral drug-experienced patients with advanced HIV disease. AIDS Res Hum Retroviruses 18:95-102, 2002
18. Kalams SA, Buchbinder SP, Rosenberg ES, Billingsley JM, Colbert DS, Jones NG, Shea AK, Trocha AK, Walker BD: Association between virus-specific cytotoxic T lymphocyte and helper responses in human immunodeficiency virus type 1 infection. J Virol 73:6715-6720, 1999
19. Seth A, Markee J, Hoering A, Sevin A, Sabath DE, Schmitz JE, Kuroda MJ, Lifton MA, Hirsch MS, Collier AC, Letvin NL, McElrath MJ: Alterations in T cell phenotype and Human Immunodeficiency Virus type-1-specific cytotoxicity after potent antiretroviral therapy. J Infect Dis 183:722-729, 2001
20. Mollet L, Li TS, Samri A, Tournay C, Tubiana R, Calvez V, Debre P, Katlama C, Autran B: Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J Immunol 165:1692-1704, 2000
21. Kalams SA, Goulder PJ, Shea AK, Jones NG, Trocha AK, Ogg GS, Walker BD: Levels of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy. J Virol 73:6721-6728, 1999
22. Champagne P, Ogg GS, King AS, Knabenhans C, Ellefsen K, Nobile M, Appay V, Rizzardi GP, Fleury S, Lipp M, Forsier R, Rowland-Jones S, Sekaly RP, McMichael AJ, Pantaleo G: Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 410:106-111, 2001
23. Lewis D, Yang L, Luo W, Wang X, Rodgers J: HIV-specific cytotoxic T lymphocyte precursors exist in a CD28-CD8+ T cell subset and increase with loss of CD4 T cells. AIDS 13:1029-1033, 1999
24. Ridge J, Di Rosa F, Maizinger P: A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393:474-478, 1998
25. Albert M, Jegathesan M, Darnell R: Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells. Nature Immunol 2:1010-1017, 2001
26. Donaghy H, Pozniak A, Gazzard B, Oazi N, Gilmour J, Gotch F, Patterson S: Loss of blood CD11c+ myeloid and CD11c-plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 98:2574-2576, 2001
27. Feldman S, Stein D, Amrute S, Denny T, Garcia Z, Kloser P, Sun Y, Megjugorac N, Fitzgerald-Bocarsly P: Decreased interferon-α production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin Immunol 101:201-210, 2001
28. Matloubian M, Concepcion R, Ahmed R: CD4+ T cells are required to sustain CD8+ cytotoxic T cell responses during chronic viral infection. J Virol 68:8056-8063, 1994
29. Wodarz D: Helper-dependent vs helper-independent CTL responses in HIV infection: Implications for drug therapy and resistance. J Theor Biol 213:447-459, 2001
30. Oxenius A, Fidler S, Brady M, Dawson SJ, Ruth K, Easterbrook PJ, Weber JN, Phillips RE, Price DA: Variable fate of virus-specific CD4+ T cells during primary HIV-1 infection. Eur J Immunol 31:3782-3786, 2001
31. Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kuntsman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA: HIV preferentially infects HIV-specific CD4+ T cells. Nature 417:95-98, 2002
32. Moss RB, Wallace MR, Giermakowska WK, Webb E, Savary J, Chamberlin-Brandt C, Theofan G, Musil R, Richieri SP, Jensen FC, Carlo DJ: Phenotypic analysis of human immunodeficiency virus (HIV) type 1 cell-mediated immune responses after treatment with an HIV-1 immunogen. J Infect Dis 180:641-648, 1999
33. Kovacs JA, Vogel S, Metcalf JA, Baseler M, Stevens R, Adelsberger J, Lempicki R, Hengel RL, Sereti I, Lambert L, Dewar RL, Davey RT Jr, Walker RE, Falloon J, Polis MA, Masur H, Lane HC: Interleukin-2 induced immune effects in human immunodeficiency virus-infected patients receiving intermittent interleukin-2 immunotherapy. Eur J Immunol 31:1351-1360, 2001
34. Moss RB, Wallace MR, Steigbigel RT, Morrison SA, Giermakowska WK, Nardo CJ, Diveley JP, Carlo DJ: Predictors of HIV-specific lymphocyte proliferative immune responses induced by therapeutic vaccination. Clin Exp Immunol 128:359-364, 2002
35. + lymphopenia. J Infect Dis 185:1401-1408, 2002
36. + T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 187:1534-1543, 2003