HIV-specific cytotoxic T lymphocyte precursors exist in a CD28-CD8+ T cell subset and increase with loss of CD4 T cells

AIDS

Volumn 13, Issue 9, 1999, Pages 1029-1033

  Lewis, Dorothy E ^a   Yang, Lixia ^a   Luo, Wei ^a   Wang, Xiao ping ^a   Rodgers, John R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

CD28; Cytotoxic T lymphocyte; Flow cytometry; HIV

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; CHROMIUM 51; GAG PROTEIN; POL PROTEIN;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; PRIORITY JOURNAL; PROLYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VIRUS IMMUNITY;

ADULT; ANTIGENS, CD28; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; HIV INFECTIONS; HUMANS; MIDDLE AGED; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032814297     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199906180-00005     Document Type: Article

References (30)

1. 1. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MBA. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 1994, 68:6103-6110.
2. 2. Legrand E, Pellegrin I, Neau D, et al. Course of specific T lymphocyte cytotoxicity, plasma and cellular viral loads, and neutralizing antibody titers in 17 recently seroconverted HIV type 1-infected patients. AIDS Res Hum Retroviruses 1997, 13:1383-1394.
3. 3. Price DA, Goulder PJR, Klenerman P, et al. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci USA 1997, 94:1890-1895.
4. 4. Carmichael A, Jin X, Sissons P, Borysiewicz, I. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 and Epstein-Barr virus in late disease. J Exp Med 1993, 177:249-256.
5. 5. Rinaldo C, Huang XL, Fan Z, et al. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J Virol 1995, 69:5838-5842.
6. 6. Greenough TC, Brettler DB, Somasundaran M, Panicali DL, Sullivan JL. Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL), virus load, and CD4 T cell loss: evidence supporting a protective role for CTL in vivo. J Infect Dis 1997, 176:118-125.
7. 7. Bariou C, Genetet J, Fuffault A, Michelet C, Cartier F, Genetet B. Longitudinal study of HIV-specific cytotoxic lymphocytes in HIV type 1-infected patients: relative balance between host immune response and the spread of HIV type 1 infection. AIDS Res Hum Retroviruses 1997, 13:1301-1312.
8. 8. Goulder PJR, Phillips RE, Colbert RA, et al. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nature Med 1997, 3:212-217.
9. 9, Ho HN, Hultin LE, Mitsuyasu RT, et al. Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993, 150:3070-3079.
10. 10. Giorgi JV, Liu Z, Hultin LE, Cumberland WG, Hennessey K, Detels R. Elevated levels of CD38-CD8+ T cells in HIV infection add to the prognostic value of low CD4- T cell levels: results of 6 years of follow-up. J Acquir Immune Defic Syndr 1993, 6:904-912.
11. 11. Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T. Expression of costimulatory molecule CD28 on T cells in Human immunodeficiency virus type 1 infection: functional and clinical correlations. J Infect Dis 1994, 169:730-738.
12. 12. Fiorentino S, Dalod M, Olive D, Guillet JG, Gomard E. Predominant involvement of CD8+CD28- lymphocytes in human immunodeficiency virus-specific cytotoxic activity. J Virol 1996, 70:2022-2026.
13. 13. Choremi-Papadopoulou H, Giglis V, Gargalianos P, Kordossis T, Iniotaki-Theodoraki A, Kosmidis J. Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during HIV-1 infection. J Acqir Immune Defic Synd 1994, 7:245-253.
14. 14. Altman JD, Moss PAH, Goulder PJR, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996, 274:94-96.
15. 15. Ogg GS, Jin X, Bonhoeffer S, et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 1998, 279:2103-2106.
16. 16. Koup RA, Pikora CA, Luzuriaga K, et al. Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with p17 and p24 specificities. J Exp Med 1991, 174:1593-1600.
17. 17. Pantaleo G, Koenig S, Baseler M, Lane HC, Fauci AS. Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. J Immunol 1990, 144:1696-1704.
18. 18. Lewis DE, Ng Lang DS, Adu-Oppong A, Schober W, Rodgers JR. Anergy and apoptosis in CD8+ T cells from HIV-infected persons. J Immunol 1994, 153:412-420.
19. 19. Lin HJ, Myers LE, Yen-Lieberman B, et al. Multicenter evaluation of quantification methods for plasma human immunodeficiency virus type 1. J Infect Dis 1994, 170:553-562.
20. 20. Lloyd TE, Yang L Ng Tang D, et al. Regulation of CD28 costimulation in human CD8+ T cells. J Immunol 1997, 158:1551-1558.
21. 21. Tosalo G. Generation of Epstein-Barr Virus (EBV)-immortalized B cell lines. Curr Prot Immunol, 1991, p. 7.22.1-7.22.3.
22. 22. Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath MJ. Cytotoxic T cell responses, viral load, and disease progression in early human immunodeficiency virus type-1 infection. New Engl J Med 1997, 337:1267-1274.
23. 23. Boudel T, Lecouer H, Gougeon ML. Apoptosis associated with ex-vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection. J Immunol 1996, 156:2282-2293.
24. 24. Azuma M, Phillips JH, Lanier LL. CD28- T lymphocytes: antigenic and functional properties. J Immunol 1993, 150:1147-1159.
25. 25. Ferbas J, Kaplan AH, Hausner MA, et al. Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity. J Infect Dis 1995, 172:329-339.
26. 26. Mugnaini EN, Spukland A, Egeland T, Sannes N, Brinchmann JE. Demonstration of identical expanded clones within both CD8+CD28+ and CD8+CD28- T cell subsets in HIV type 1-infected individuals. T cell subsets in HIV type 1-infected individuals. Eur J Immunol 1998, 28:1738-1742.
27. 27. Shahinian A, Pfeffer K, Lee KP, et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993, 261:609-612.
28. 28. Morley JK, Batliwalla FM, Hingorani R, Gregersen PK. Oligoclonal CD8+ T cells are preferentially expanded in the CD57+ subset. J Immunol 1995, 154:6182-6190.
29. 29. Monteiro J, Batliwalla F, Ostrer J, Gregersen PK. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+ CD8+ counterparts. J Immunol 1996, 156:3587-3590.
30. 30. Hamann D, Baar PA, Rep MHG, et al. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 1997, 186:1407-1418.