Effects of folic acid fortification and multivitamin therapy on homocysteine and vitamin B12 status in cardiac transplant recipients

Journal of Heart and Lung Transplantation

Volumn 23, Issue 4, 2004, Pages 405-412

  Miriuka, Santiago G ^a,c   Langman, Loralie J ^a,d   Keren, Eitan S ^a,c   Miner, Steven E S ^a,c   Mamer, Orval A ^e   Delgado, Diego H ^a,c   Evrovski, Jovan ^a,c   Ross, Heather J ^a,c   Cole, David E C ^a,b,c,f  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^e MCGILL UNIVERSITY   (Canada)

^f NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; COBALAMIN; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHIONINE SYNTHASE; METHYLMALONIC ACID; MULTIVITAMIN; PYRIDOXINE;

ADULT; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLIC ACID BLOOD LEVEL; GENETIC POLYMORPHISM; GENOTYPE; HEART TRANSPLANTATION; HEMOCONCENTRATION; HUMAN; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RECIPIENT; TISSUE LEVEL; TREATMENT OUTCOME; URINARY EXCRETION; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADULT; CANADA; COHORT STUDIES; DIETARY SUPPLEMENTS; FEMALE; FERREDOXIN-NADP REDUCTASE; FOLIC ACID; FOOD, FORTIFIED; HEART TRANSPLANTATION; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); METHYLMALONIC ACID; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; VITAMIN B 12; VITAMINS;

EID: 1842581998     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-2498(03)00202-X     Document Type: Article

References (36)

1. Welch G.N., Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 338:1998;1042-1050.
2. Miriuka SG, Delgado DH, Cole DEC, Rao V, Ross HJ. Hyperhomocysteinemia in heart transplantation: from bench to bedside. J Heart Lung Transplant. 2003 (in press)
3. Ambrosi P., Barlatier A., Habib G., et al. Hyperhomocysteinaemia in heart transplant recipients. Eur Heart J. 15:1994;1191-1195.
4. Berger P.B., Jones J.D., Olson L.J., et al. Increase in total plasma homocysteine concentration after cardiac transplantation. Mayo Clin Proc. 70:1995;125-131.
5. Cole D.E., Ross H.J., Evrovski J., et al. Correlation between total homocysteine and cyclosporine concentrations in cardiac transplant recipients. Clin Chem. 44:1998;2307-2312.
6. Cook R.C., Tupper J.K., Parker S., et al. Effect of immunosuppressive therapy, serum creatinine, and time after transplant on plasma total homocysteine in patients following heart transplantation. J Heart Lung Transplant. 18:1999;420-424.
7. Gupta A., Moustapha A., Jacobsen D.W., et al. High homocysteine, low folate, and low vitamin B6 concentrations prevalent risk factors for vascular disease in heart transplant recipients. Transplantation. 65:1998;544-550.
8. Miner S.E., Cole D.E., Evrovski J., Verma A., Daly P.A., Ross H.J. Hyperhomocysteinemia and transplant coronary artery disease in cardiac transplant recipients. Clin Transplant. 15:2001;258-262.
9. Ambrosi P., Garcon D., Riberi A., et al. Association of mild hyperhomocysteinemia with cardiac graft vascular disease. Atherosclerosis. 138:1998;347-350.
10. Weis M., von Scheidt W. Cardiac allograft vasculopathy a review. Circulation. 96:1997;2069-2077.
11. Schneede J., Refsum H., Ueland P.M. Biological and environmental determinants of plasma homocysteine. Semin Thromb Hemost. 26:2000;263-279.
12. Ray J.G., Vermeulen M.J., Boss S.C., Cole D.E. Increased red cell folate concentrations in women of reproductive age after Canadian folic acid food fortification. Epidemiology. 13:2002;238-240.
13. Ray J.G., Vermeulen M.J., Boss S.C., Cole D.E. Declining rate of folate insufficiency among adults following increased folic acid food fortification in Canada. Can J Public Health. 93:2002;249-253.
14. Tice J.A., Ross E., Coxson P.G., et al. Cost-effectiveness of vitamin therapy to lower plasma homocysteine levels for the prevention of coronary heart disease effect of grain fortification and beyond. JAMA. 286:2001;936-943.
15. Klee G.G. Cobalamin and folate evaluation measurement of methylmalonic acid and homocysteine vs vitamin B. (12) and folate Clin Chem. 46:2000;1277-1283.
16. Miner S.E., Cole D.E., Evrovski J., et al. Pyridoxine improves endothelial function in cardiac transplant recipients. J Heart Lung Transplant. 20:2001;964-969.
17. Miner S.E., Cole D.E., Evrovski J., et al. N-acetylcysteine neither lowers plasma homocysteine concentrations nor improves brachial artery endothelial function in cardiac transplant recipients. Can J Cardiol. 18:2002;503-507.
18. Cole D.E., Lehotay D.C., Evrovski J. Simplified simultaneous assay of total plasma homocysteine and methionine by HPLC and pulsed integrated amperometry. Clin Chem. 44:1998;188-190.
19. Evrovski J., Callaghan M., Cole D.E. Determination of homocysteine by HPLC with pulsed integrated amperometry. Clin Chem. 41:1995;757-758.
20. Mamer OA, Glifix BM, Rosenblett DS, Cooper BA. Determination of homocysteine and methylmalonic acid in plasma in a single GC/MS run. Proceedings of the 42nd ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, 1994:1158.
21. Cole D.E.C., Langman L.J., Miner S.E.S., Matte M., Wong B.Y.L., Ross H.J. Frequency of the MTRR A66G polymorphism in cardiac transplant recipients with hyperhomocysteinemia. Can J Cardiol. 71:(supplC):2001;202.
22. Cooke G.E., Eaton G.M., Whitby G., et al. Plasma atherogenic markers in congestive heart failure and posttransplant. (heart)patients J Am Coll Cardiol. 36:2000;509-516.
23. Jacques P.F., Selhub J., Bostom A.G., Wilson P.W., Rosenberg I.H. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 340:1999;1449-1454.
24. Cook R.C., Parker S., Kingsbury K., et al. Effective treatment of hyperhomocysteinemia in heart transplant recipients with and without renal failure. J Heart Lung Transplant. 20:2001;310-315.
25. Mills J.L. Fortification of foods with folic acid - how much is enough? N Engl J Med. 342:2000;1442-1445.
26. Bok J., Faber J., De Vries J., Hroese W., Nieweg H. The effect of pteroylglutamic acid administration on serum vitamin B12 concentrations in pernicious anemia in relapse. J Lab Clin Med. 51:1958;667-671.
27. Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 54:1996;382-390.
28. Anonymous. Guidelines on the investigation and diagnosis of cobalamin and folate deficiencies. A publication of the British Committee for Standards in Haematology. BCSH General Haematology Test Force. Clin Lab Haematol. 16:1994;101-115.
29. Elin R.J., Winter W.E. Methylmalonic acid a test whose time has come? Arch Pathol Lab Med. 125:2001;824-827.
30. Holleland G., Schneede J., Ueland P.M., Lund P.K., Refsum H., Sandberg S. Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies. Clin Chem. 45:1999;189-198.
31. Schneede J., Dagnelie P.C., van Staveren W.A., Vollset S.E., Refsum H., Ueland P.M. Methylmalonic acid and homocysteine in plasma as indicators of functional cobalamin deficiency in infants on macrobiotic diets. Pediatr Res. 36:1994;194-201.
32. Lindenbaum J., Healton E.B., Savage D.G., et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 318:1988;1720-1728.
33. Moelby L., Rasmussen K., Rasmussen H.H. Serum methylmalonic acid in uraemia. Scand J Clin Lab Invest. 52:1992;351-354.
34. Stein G., Muller A., Busch M., Fleck C., Sperschneider H. Homocysteine, its metabolites, and B-group vitamins in renal transplant patients. Kidney Int Suppl. 78:2001;S262-265.
35. Harmon D.L., Shields D.C., Woodside J.V., et al. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol. 17:1999;298-309.
36. Ma J., Stampfer M.J., Christensen B., et al. A polymorphism of the methionine synthase gene association with plasma folate, vitamin B12, homocyst. (e)ine, and colorectal cancer risk Cancer Epidemiol Biomarkers Prev. 8:1999;825-829.